{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T05:31:07Z","timestamp":1776317467227,"version":"3.50.1"},"reference-count":46,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T00:00:00Z","timestamp":1698710400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Institute of General Medical Sciences of the NIH","award":["SC2 GM136612"],"award-info":[{"award-number":["SC2 GM136612"]}]},{"name":"College of Pharmacy and Health Sciences, St. John\u2019s University","award":["SC2 GM136612"],"award-info":[{"award-number":["SC2 GM136612"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>In the present work, a series of N-terpenyl organoselenium compounds (CHB1-6) were evaluated for antimycotic activity by determining the minimum inhibitory concentration (MIC) for each compound in fluconazole (FLU)-sensitive (S1) and FLU-resistant (S2) strains of Candida albicans (C. albicans). The most active compounds in the MIC screen were CHB4 and CHB6, which were then evaluated for cytotoxicity in human cervical cancer cells (KB-3-1) and found to be selective for fungi. Next, CHB4 and CHB6 were investigated for skin irritation using a reconstructed 3D human epidermis and both compounds were considered safe to the epidermis. Using a mouse model of vulvovaginal candidiasis (VVC), CHB4 and CHB6 both exhibited antimycotic efficacy by reducing yeast colonization of the vaginal tract, alleviating injury to the vaginal mucosa, and decreasing the abundance of myeloperoxidase (MPO) expression in the tissue, indicating a reduced inflammatory response. In conclusion, CHB4 and CHB6 demonstrate antifungal activity in vitro and in the mouse model of VVC and represent two new promising antifungal agents.<\/jats:p>","DOI":"10.3390\/molecules28217377","type":"journal-article","created":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T12:53:32Z","timestamp":1698756812000},"page":"7377","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Selected N-Terpenyl Organoselenium Compounds Possess Antimycotic Activity In Vitro and in a Mouse Model of Vulvovaginal Candidiasis"],"prefix":"10.3390","volume":"28","author":[{"given":"Xiuyi","family":"Liang","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences, St. John\u2019s University, Queens, NY 11439, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7619-9288","authenticated-orcid":false,"given":"Agata J.","family":"Pacu\u0142a-Miszewska","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry, Nicolaus Copernicus University, 87-100 Toru\u0144, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdalena","family":"Obieziurska-Fabisiak","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry, Nicolaus Copernicus University, 87-100 Toru\u0144, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richa","family":"Vartak","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, St. John\u2019s University, Queens, NY 11439, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ganming","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, St. John\u2019s University, Queens, NY 11439, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8252-0234","authenticated-orcid":false,"given":"Ketankumar","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, St. John\u2019s University, Queens, NY 11439, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1706-6108","authenticated-orcid":false,"given":"Natalya U.","family":"Fedosova","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, Aarhus University, 8000 Aarhus, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3868-2022","authenticated-orcid":false,"given":"Jacek","family":"\u015acianowski","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry, Nicolaus Copernicus University, 87-100 Toru\u0144, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7180-5955","authenticated-orcid":false,"given":"Blase","family":"Billack","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, St. John\u2019s University, Queens, NY 11439, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/s12905-019-0748-8","article-title":"Current patient perspectives of vulvovaginal candidiasis: Incidence, symptoms, management and post-treatment outcomes","volume":"19","author":"Yano","year":"2019","journal-title":"BMC Women\u2019s Health"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Neal, C.M., and Martens, M.G. 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