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Project","award":["23JC021"],"award-info":[{"award-number":["23JC021"]}]},{"name":"China Selenium Rich Industry Research Institute Selenium Rich Special Research and Development Project","award":["23JC020"],"award-info":[{"award-number":["23JC020"]}]},{"name":"China Selenium Rich Industry Research Institute Selenium Rich Special Research and Development Project","award":["2021FXZX06"],"award-info":[{"award-number":["2021FXZX06"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Chromium picolinate (CP) is an organic compound that has long been used to treat diabetes. Our previous studies found CP could relieve diabetic nephropathy. Thus, we speculate that it might have a positive effect on diabetic testicular injury. In this study, a diabetic rat model was established, and then the rats were treated with CP for 8 weeks. We found that the levels of blood glucose, food, and water intake were reduced, and body weight was enhanced in diabetic rats after CP supplementation. Meanwhile, in CP treatment groups, the levels of male hormone and sperm parameters were improved, the pathological structure of the testicular tissue was repaired, and testicular fibrosis was inhibited. In addition, CP reduced the levels of serum inflammatory cytokines, and decreased oxidative stress and apoptosis in the testicular tissue. In conclusion, CP could ameliorate testicular damage in diabetic rats, as well as being a potential testicle-protective nutrient in the future to prevent the testicular damage caused by diabetes.<\/jats:p>","DOI":"10.3390\/molecules28227669","type":"journal-article","created":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T11:31:36Z","timestamp":1700479896000},"page":"7669","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Chromium Picolinate Protects against Testicular Damage in STZ-Induced Diabetic Rats via Anti-Inflammation, Anti-Oxidation, Inhibiting Apoptosis, and Regulating the TGF-\u03b21\/Smad Pathway"],"prefix":"10.3390","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4391-000X","authenticated-orcid":false,"given":"Hongxing","family":"Zheng","sequence":"first","affiliation":[{"name":"School of Biological Science and Engineering, Shaanxi University of Technology, Hanzhong 723000, China"},{"name":"State Key Laboratory of Qinba Biological Resources and Ecological Environment, Hanzhong 723000, China"},{"name":"Shaanxi Black Organic Food Engineering Technology Research Center, Hanzhong 723000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingjun","family":"Hu","sequence":"additional","affiliation":[{"name":"School of Biological Science and Engineering, Shaanxi University of Technology, Hanzhong 723000, China"},{"name":"Qinba Mountain Area Collaborative Innovation Center of Bioresources Comprehensive Development, Hanzhong 723000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengli","family":"Shao","sequence":"additional","affiliation":[{"name":"School of Biological Science and Engineering, Shaanxi University of Technology, Hanzhong 723000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simin","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Biological Science and Engineering, Shaanxi University of Technology, Hanzhong 723000, China"},{"name":"Shaanxi Province Key Laboratory of Bioresources, Hanzhong 723000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanshan","family":"Qi","sequence":"additional","affiliation":[{"name":"School of Biological Science and Engineering, Shaanxi University of Technology, Hanzhong 723000, China"},{"name":"Shaanxi Daoerfeng Biotechnology Company, Hanzhong 723000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,11,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"850","DOI":"10.4239\/wjd.v6.i6.850","article-title":"Diabetes mellitus: The epidemic of the century","volume":"6","author":"Kharroubi","year":"2015","journal-title":"World J. 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