{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T12:52:05Z","timestamp":1783947125351,"version":"3.55.0"},"reference-count":55,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T00:00:00Z","timestamp":1700524800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>This study investigated the potential acaricidal and repellent effects of tar obtained from the Lebanon cedar (Cedrus libani A. Rich.) against the brown dog tick species Rhipicephalus sanguineus sensu lato Latreille (Acari: Ixodidae). The goal was to find an alternative, safe, and effective way to eliminate ticks. Tar is traditionally extracted from cedar trees in the Antalya region of T\u00fcrkiye. The composition of the tar is primarily characterized by a diverse mixture of terpenes, with \u03b2-himachalene (29.16%), \u03b1-atlantone (28.7%), ar-turmerone (8.82%), longifolene-(V4) (6.66%), \u03b1-himachalene (5.28%), and \u03b2-turmerone (5.12%) emerging as the predominant constituents. The toxic effects of tar on tick larvae were studied through larval immersion tests (LIT), and its repellent activity was evaluated using a new larval repellent activity test (LRAT). The results revealed significant acaricidal effects, with mortality rates of 77.7% and 82.2% for the Konyaalti and Kepez strains of the brown dog tick, respectively, in response to a 1% concentration of tar. LC50 and LC90 values were determined as 0.47% and 1.52% for the Kepez strain and 0.58% and 1.63% for the Konyaalti strain, respectively. When comparing the repellent effect of tar to the widely used synthetic repellent DEET, repellency rates of up to 100% were observed. As a result, this study establishes, for the first time, the larvicidal and repellent effects of C. libani tar on ticks.<\/jats:p>","DOI":"10.3390\/molecules28237689","type":"journal-article","created":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T12:12:13Z","timestamp":1700568733000},"page":"7689","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Exploring the Larvicidal and Repellent Potential of Taurus Cedar (Cedrus libani) Tar against the Brown Dog Tick (Rhipicephalus sanguineus sensu lato)"],"prefix":"10.3390","volume":"28","author":[{"given":"Samed","family":"Koc","sequence":"first","affiliation":[{"name":"Department of Biology, Faculty of Science, Akdeniz University, Antalya 07070, T\u00fcrkiye"},{"name":"Laboratory Animals Application and Research Centre, Akdeniz University, Antalya 07070, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeynep Nur","family":"Gultekin","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Science, Akdeniz University, Antalya 07070, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sevval","family":"Kahraman","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Science, Akdeniz University, Antalya 07070, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aysegul","family":"Cengiz","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Science, Akdeniz University, Antalya 07070, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burak","family":"Polat","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Science, Akdeniz University, Antalya 07070, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cansu","family":"Caliskan","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Science, Akdeniz University, Antalya 07070, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tolga","family":"Yildirim","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Science, Akdeniz University, Antalya 07070, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3145-5716","authenticated-orcid":false,"given":"Ozge","family":"Tufan-Cetin","sequence":"additional","affiliation":[{"name":"Department of Environmental Protection Technology, Vocational School of Technical Sciences, Akdeniz University, Antalya 07070, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9758-6356","authenticated-orcid":false,"given":"Huseyin","family":"Cetin","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Science, Akdeniz University, Antalya 07070, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,11,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/j.crvi.2010.05.003","article-title":"Cedrus libani (A. 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