{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T08:49:28Z","timestamp":1790758168174,"version":"4.1.0"},"reference-count":56,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T00:00:00Z","timestamp":1700611200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Programa de Apoyo a Proyectos de Investigaci\u00f3n e Innovaci\u00f3n Tecnol\u00f3gica (PAPIIT)","award":["IN221010"],"award-info":[{"award-number":["IN221010"]}]},{"name":"Coordinaci\u00f3n de Investigaci\u00f3n of the School Medicine, UNAM","award":["IN221010"],"award-info":[{"award-number":["IN221010"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Chiranthodendron pentadactylon Larreat is a tree native to southeastern Mexico and Guatemala. Its flower is used in Mexican folk medicine to treat a variety of diseases, including conditions of blood pressure. However, scientific information on its usefulness in this pathology is lacking. The present study evaluates the effect of a methanolic extract (ME) from the flower and its active constituents on heart rate (HR) and mean arterial pressure (MAP) in anesthetized rats (MAPHR). The study also analyzed the effects on rat-isolated aortic rings (RIAR) and the rat mesenteric arterial bed (MABR). Active fractions were chromatographed, which led to the isolation of cyanidin 3-O-glucoside (C3G) identified through HPLC. The Chiranthodendron\u00a0pentadactylon flowers produced hypotensive and vasorelaxant effects associated with C3G. The vasorelaxant effect is a mechanism underlying the synthesis and release of nitric oxide (NO). Neither cholinergic receptors nor prostaglandins are involved. ME and C3G cause cardiovascular depression in anesthetized rats via cholinergic and prostanoid mechanisms. Our research expands the scientific understanding of the flowers on the rat cardiovascular system. This amplifies the appreciation of the flower\u2019s ethnomedicine employed to control blood pressure. However, researchers need to conduct toxicity studies to determine the safety of this plant.<\/jats:p>","DOI":"10.3390\/molecules28237698","type":"journal-article","created":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T04:21:27Z","timestamp":1700626887000},"page":"7698","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The Hypotensive and Vasodilatory Effects Observed in Rats Exposed to Chiranthodendron pentadactylon Larreat Flowers Can Be Attributed to Cyanidin 3-O-Glucoside"],"prefix":"10.3390","volume":"28","author":[{"given":"Juan Luis","family":"Escobar-Ram\u00edrez","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine, University National Autonomous of Mexico, Mexico City 04510, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacinto","family":"Santiago-Mej\u00eda","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine, University National Autonomous of Mexico, Mexico City 04510, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maribel","family":"Soto-N\u00fa\u00f1ez","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine, University National Autonomous of Mexico, Mexico City 04510, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1662-0872","authenticated-orcid":false,"given":"Oscar Salvador","family":"Barrera-V\u00e1zquez","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine, University National Autonomous of Mexico, Mexico City 04510, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Vargas-Querea","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine, University National Autonomous of Mexico, Mexico City 04510, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gil Alfonso","family":"Magos-Guerrero","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine, University National Autonomous of Mexico, Mexico City 04510, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,11,22]]},"reference":[{"key":"ref_1","unstructured":"Thouvenot (2014). 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