{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:24:03Z","timestamp":1791235443781,"version":"4.1.0"},"reference-count":130,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T00:00:00Z","timestamp":1701129600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Natural Science Foundation of China","award":["82304481"],"award-info":[{"award-number":["82304481"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Diabetic cardiomyopathy (DCM) is a pathophysiological condition triggered by diabetes mellitus (DM), which can lead to heart failure (HF). One of the most important cellular processes associated with DCM is the death of cardiomyocytes. Gasdermin D (GSDMD) plays a key role in mediating pyroptosis, a type of programmed cell death closely associated with inflammasome activation. Recent studies have revealed that pyroptosis is induced during hyperglycemia, which is crucial to the development of DCM. Although the effects of pyroptosis on DCM have been discussed, the relationship between DCM and GSDMD is not fully clarified. Recent studies gave us the impetus for clarifying the meaning of GSDMD in DCM. The purpose of this review is to summarize new and emerging insights, mainly discussing the structures of GSDMD and the mechanism of pore formation, activation pathways, molecular mechanisms of GSDMD-mediated pyroptosis, and the therapeutic potential of GSDMD in DCM. The implications of this review will pave the way for a new therapeutic target in DCM.<\/jats:p>","DOI":"10.3390\/molecules28237813","type":"journal-article","created":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T07:41:32Z","timestamp":1701157292000},"page":"7813","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Gasdermin D-Mediated Pyroptosis in Diabetic Cardiomyopathy: Molecular Mechanisms and Pharmacological Implications"],"prefix":"10.3390","volume":"28","author":[{"given":"Zhou","family":"Liu","sequence":"first","affiliation":[{"name":"Institute of Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China"},{"name":"Key Laboratory of Glucolipid Metabolic Disorder, Ministry of Education, Guangzhou 510006, China"},{"name":"Guangdong TCM Key Laboratory for Metabolic Diseases, Guangzhou 510006, China"},{"name":"Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China"},{"name":"Key Laboratory of Glucolipid Metabolic Disorder, Ministry of Education, Guangzhou 510006, China"},{"name":"Guangdong TCM Key Laboratory for Metabolic Diseases, Guangzhou 510006, China"},{"name":"Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Mei","sequence":"additional","affiliation":[{"name":"Institute of Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China"},{"name":"Key Laboratory of Glucolipid Metabolic Disorder, Ministry of Education, Guangzhou 510006, China"},{"name":"Guangdong TCM Key Laboratory for Metabolic Diseases, Guangzhou 510006, China"},{"name":"Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiling","family":"Yan","sequence":"additional","affiliation":[{"name":"Institute of Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China"},{"name":"Key Laboratory of Glucolipid Metabolic Disorder, Ministry of Education, Guangzhou 510006, China"},{"name":"Guangdong TCM Key Laboratory for Metabolic Diseases, Guangzhou 510006, China"},{"name":"Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4446-7035","authenticated-orcid":false,"given":"Haihai","family":"Liang","sequence":"additional","affiliation":[{"name":"Institute of Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China"},{"name":"Key Laboratory of Glucolipid Metabolic Disorder, Ministry of Education, Guangzhou 510006, China"},{"name":"Guangdong TCM Key Laboratory for Metabolic Diseases, Guangzhou 510006, China"},{"name":"Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,11,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1210\/er.2008-0024","article-title":"The metabolic syndrome","volume":"29","author":"Cornier","year":"2008","journal-title":"Endocr. 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