{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T16:41:13Z","timestamp":1788885673132,"version":"build-2803163510"},"reference-count":49,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2023,11,30]],"date-time":"2023-11-30T00:00:00Z","timestamp":1701302400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Basic Research Operating Expenses for Undergraduate Colleges","award":["2022-KYYWF-0609"],"award-info":[{"award-number":["2022-KYYWF-0609"]}]},{"DOI":"10.13039\/501100014902","name":"Universities in Heilongjiang Province Research Program","doi-asserted-by":"publisher","award":["2022-KYYWF-0609"],"award-info":[{"award-number":["2022-KYYWF-0609"]}],"id":[{"id":"10.13039\/501100014902","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>The goal of the current study was to explore the potential benefits of Tretinoin (Tre) fatty acid vesicles (Tre-FAV) as a prospective antipsoriatic topical delivery system. This promising system can counteract the drug challenges in terms of its extremely low aqueous solubility, instability, skin irritation, and serious systemic adverse effects. Tre-loaded fatty acid vesicles were successfully developed and entirely characterised. The selected formulation was investigated for in vitro release, ex vivo skin retention and psoriasis efficacy studies. The characterisation results of Tre-FAV showed it has a globular shape with a particle size of 126.37 \u00b1 1.290 nm (0.188 \u00b1 0.019 PDI). The entrapment efficiency and zeta potential were discovered to be 84.26 \u00b1 0.816% and \u221228.9 \u00b1 1.92 mV, respectively. Encapsulation of the drug in the fatty acid vesicles was also strengthened by differential scanning calorimetric and powder FTIR diffraction studies. In vitro release results showed that Tre-FAV significantly increased skin absorption and retention in comparison to the Tre solution. The topical application of Tre-FAV to a mouse model confirmed that it has superior in vivo antipsoriatic properties in terms of well-demarcated papules, erythema and reduced epidermal thickness in comparison to other treatments. The weight of the spleen and the levels of the cytokines IL-17 and IL-6 decreased after treatment. In conclusion, FAV dramatically increased the water solubility and skin permeability of Tre and its anti-psoriasis activity.<\/jats:p>","DOI":"10.3390\/molecules28237868","type":"journal-article","created":{"date-parts":[[2023,11,30]],"date-time":"2023-11-30T09:39:12Z","timestamp":1701337152000},"page":"7868","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Design and Evaluation of Tretinoin Fatty Acid Vesicles for the Topical Treatment of Psoriasis"],"prefix":"10.3390","volume":"28","author":[{"given":"Yaxin","family":"Zhao","sequence":"first","affiliation":[{"name":"College of Pharmacy, Jiamusi University, Jiamusi 154007, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Jiamusi University, Jiamusi 154007, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bohang","family":"Zou","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Jiamusi University, Jiamusi 154007, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Fu","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Jiamusi University, Jiamusi 154007, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shushan","family":"Ren","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Jiamusi University, Jiamusi 154007, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Jiamusi University, Jiamusi 154007, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,11,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"5965","DOI":"10.12998\/wjcc.v10.i18.5965","article-title":"Identification of potential key molecules and signaling pathways for psoriasis based on weighted gene co-expression network analysis","volume":"10","author":"Shu","year":"2022","journal-title":"World J. Clin. Cases"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.jconrel.2016.07.003","article-title":"Advances in psoriasis physiopathology and treatments: Up to date of mechanistic insights and perspectives of novel therapies based on innovative skin drug delivery systems (ISDDS)","volume":"239","author":"Sala","year":"2016","journal-title":"J. Control. Release"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"155041","DOI":"10.1016\/j.phymed.2023.155041","article-title":"Phytochemicals: Targeting autophagy to treat psoriasis","volume":"120","author":"Chen","year":"2023","journal-title":"Phytomedicine"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s12016-016-8535-x","article-title":"The Inflammatory Response in Psoriasis: A Comprehensive Review","volume":"50","author":"Deng","year":"2016","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1089\/adt.2023.014","article-title":"Psoriasis: Striving for Potential Biomarkers","volume":"21","author":"Dan","year":"2023","journal-title":"ASSAY Drug Dev. Technol."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Bro\u017cyna, A.A., Slominski, R.M., Nedoszytko, B., Zmijewski, M.A., and Slominski, A.T. (2022). Vitamin D Signaling in Psoriasis: Pathogenesis and Therapy. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23158575"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"7","DOI":"10.12788\/cutis.0038","article-title":"Psoriasis in patients of color: Differences in morphology, clinical presentation, and treatment","volume":"106","author":"Nicholas","year":"2020","journal-title":"Cutis"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Nowowiejska, J., Baran, A., and Flisiak, I. (2021). Aberrations in Lipid Expression and Metabolism in Psoriasis. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22126561"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e12632","DOI":"10.1111\/dth.12632","article-title":"Efficacy, safety, and cost-effectiveness of all-trans retinoic acid\/Clobetasol Propionate Compound Ointment in the treatment of mild to moderate psoriasis vulgaris: A randomized, single-blind, multicenter clinical trial","volume":"31","author":"Xia","year":"2018","journal-title":"Dermatol. Ther."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1111\/jdv.18761","article-title":"The role of topical therapies along the psoriasis patient journey: An overview from the Symposium \u2018Tailoring topical psoriasis treatments to patients\u2019 needs and expectations\u2019 of the 30th EADV Congress 2021","volume":"37","author":"Pinter","year":"2023","journal-title":"J. Eur. Acad. Dermatol. Venereol. JEADV"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"971","DOI":"10.3892\/etm.2021.10403","article-title":"Experimental research in topical psoriasis therapy (Review)","volume":"22","author":"Costescu","year":"2021","journal-title":"Exp. Ther. Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1080\/09546634.2020.1789043","article-title":"Mometasone furoate-loaded aspasomal gel for topical treatment of psoriasis: Formulation, optimization, in vitro and in vivo performance","volume":"33","author":"Shinde","year":"2022","journal-title":"J. Dermatol. Treat."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"4569","DOI":"10.2174\/1381612826666200614175236","article-title":"Nanostructured Lipid Carriers as Potential Drug Delivery Systems for Skin Disorders","volume":"26","author":"Waghule","year":"2020","journal-title":"Curr. Pharm. Des."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.ijpharm.2013.08.019","article-title":"Nano-lipoidal carriers of tretinoin with enhanced percutaneous absorption, photostability, biocompatibility and anti-psoriatic activity","volume":"456","author":"Raza","year":"2013","journal-title":"Int. J. Pharm."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2372","DOI":"10.1039\/C8BM01569D","article-title":"A dual deformable liposomal ointment functionalized with retinoic acid and epidermal growth factor for enhanced burn wound healing therapy","volume":"7","author":"Lu","year":"2019","journal-title":"Biomater. Sci."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"126","DOI":"10.4103\/idoj.idoj_222_21","article-title":"Topical Tretinoin in the Treatment of Nail Psoriasis","volume":"13","author":"Grover","year":"2022","journal-title":"Indian Dermatol. Online J."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1067\/mjd.2001.117730","article-title":"An analysis of reports of depression and suicide in patients treated with isotretinoin","volume":"45","author":"Wysowski","year":"2001","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1152\/physrev.2000.80.3.1021","article-title":"Retinoids in embryonal development","volume":"80","author":"Ross","year":"2000","journal-title":"Physiol. Rev."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Cuomo, F., Ceglie, S., Miguel, M., Lindman, B., and Lopez, F. (2021). Oral delivery of all-trans retinoic acid mediated by liposome carriers. Colloids Surf. B Biointerfaces, 201.","DOI":"10.1016\/j.colsurfb.2021.111655"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"251","DOI":"10.3109\/21691401.2016.1146729","article-title":"Fatty acid vesicles acting as expanding horizon for transdermal delivery","volume":"45","author":"Kumar","year":"2017","journal-title":"Artif. Cells Nanomed. Biotechnol."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Atef, B., Ishak, R.A.H., Badawy, S.S., and Osman, R. (2023). 10-Hydroxy Decanoic Acid-Based Vesicles as a Novel Topical Delivery System: Would It Be a Better Platform Than Conventional Oleic Acid Ufasomes for Skin Cancer Treatment?. Pharmaceutics, 15.","DOI":"10.3390\/pharmaceutics15051461"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"30","DOI":"10.2174\/1574891X15999201110212725","article-title":"Corrigendum to: Oleic Acid Vesicles as a New Approach for Transdermal Delivery of Econazole Nitrate: Development, Characterization, and In-vivo Evaluation in Wistar Rats","volume":"16","author":"Verma","year":"2021","journal-title":"Recent Adv. Anti-Infect. Drug Discov."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1007\/s12551-020-00753-x","article-title":"Dynamics of the vesicles composed of fatty acids and other amphiphile mixtures: Unveiling the role of fatty acids as a model protocell membrane","volume":"12","author":"Kundu","year":"2020","journal-title":"Biophys. Rev."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"95","DOI":"10.3109\/21691401.2013.794351","article-title":"Oleic acid vesicles: A new approach for topical delivery of antifungal agent","volume":"42","author":"Verma","year":"2014","journal-title":"Artif. Cells Nanomed. Biotechnol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"110554","DOI":"10.1016\/j.lwt.2020.110554","article-title":"Nanoliposomes as delivery system for anthocyanins: Physicochemical characterization, cellular uptake, and antioxidant properties","volume":"139","author":"Sun","year":"2021","journal-title":"LWT"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"278","DOI":"10.4103\/ijp.IJP_591_20","article-title":"Natural product topical therapy in mitigating imiquimod-induced psoriasis-like skin inflammation-underscoring the anti-psoriatic potential of Nimbolide","volume":"53","author":"More","year":"2021","journal-title":"Indian J. Pharmacol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"213","DOI":"10.4196\/kjpp.2020.24.3.213","article-title":"Salvianolic acid B ameliorates psoriatic changes in imiquimod-induced psoriasis on BALB\/c mice by inhibiting inflammatory and keratin markers via altering phosphatidylinositol-3-kinase\/protein kinase B signaling pathway","volume":"24","author":"Wang","year":"2020","journal-title":"Korean J. Physiol. Pharmacol."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Liu, L., Ji, F., Zhao, Y., and Hai, X. (2023). Arsenic trioxide liposome gels for the treatment of psoriasis in mice. J. Liposome Res.","DOI":"10.1080\/08982104.2023.2251054"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.apsb.2021.07.019","article-title":"Enhanced uptake and anti-maturation effect of celastrol-loaded mannosylated liposomes on dendritic cells for psoriasis treatment","volume":"12","author":"Xi","year":"2022","journal-title":"Acta Pharm. Sin. B"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1159\/000373955","article-title":"Glycyrrhizin ameliorates imiquimod-induced psoriasis-like skin lesions in BALB\/c mice and inhibits TNF-\u03b1-induced ICAM-1 expression via NF-\u03baB\/MAPK in HaCaT cells","volume":"35","author":"Xiong","year":"2015","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"120826","DOI":"10.1016\/j.ijpharm.2021.120826","article-title":"Co-delivery of methotrexate and nicotinamide by cerosomes for topical psoriasis treatment with enhanced efficacy","volume":"605","author":"Yang","year":"2021","journal-title":"Int. J. Pharm."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Zhang, Y., Wang, Q., Sun, S., and Jiang, L. (2023). The therapeutic effect of glycyrrhizic acid compound ointment on imiquimod-induced psoriasis-like disease in mice. PLoS ONE, 18.","DOI":"10.1371\/journal.pone.0290637"},{"key":"ref_33","first-page":"675","article-title":"Cytokines of the IL-17 family in psoriasis","volume":"18","author":"Lauffer","year":"2020","journal-title":"JDDG J. Der Dtsch. Dermatol. Ges."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.2147\/CCID.S423922","article-title":"Curcumin Alleviates Epidermal Psoriasis-Like Dermatitis and IL-6\/STAT3 Pathway of Mice","volume":"16","author":"Cai","year":"2023","journal-title":"Clin. Cosmet. Investig. Dermatol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"101734","DOI":"10.1016\/j.jsps.2023.101734","article-title":"Formulation optimization, in vitro and in vivo evaluation of niosomal nanocarriers for enhanced topical delivery of cetirizine","volume":"31","author":"Aldawsari","year":"2023","journal-title":"Saudi Pharm. J."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2428","DOI":"10.1080\/10717544.2022.2103600","article-title":"Corneal targeted fenticonazole nitrate-loaded novasomes for the management of ocular candidiasis: Preparation, in vitro characterization, ex vivo and in vivo assessments","volume":"29","author":"Ahmed","year":"2022","journal-title":"Drug Deliv."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Ghodke, J., Ekonomou, S.I., Weaver, E., Lamprou, D., Doran, O., and Stratakos, A.C. (2023). The Manufacturing and Characterisation of Eugenol-Enclosed Liposomes Produced by Microfluidic Method. Foods, 12.","DOI":"10.3390\/foods12152940"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Kumar, P., Singh, S.K., Handa, V., and Kathuria, H. (2018). Oleic Acid Nanovesicles of Minoxidil for Enhanced Follicular Delivery. Medicines, 5.","DOI":"10.3390\/medicines5030103"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"238","DOI":"10.2174\/1574885514666190722164119","article-title":"Oleic Acid Vesicles for Transdermal Delivery of Propranolol Hydrochloride: Development and Characterization","volume":"15","author":"Kumar","year":"2020","journal-title":"Curr. Drug Ther."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.steroids.2015.05.012","article-title":"Design, characterization and skin permeating potential of Fluocinolone acetonide loaded nanostructured lipid carriers for topical treatment of psoriasis","volume":"101","author":"Pradhan","year":"2016","journal-title":"Steroids"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Shehata, T.M., Ibrahim, M.M., and Elsewedy, H.S. (2021). Curcumin Niosomes Prepared from Proniosomal Gels: In Vitro Skin Permeability, Kinetic and In Vivo Studies. Polymers, 13.","DOI":"10.3390\/polym13050791"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Lu, B., Huang, Y., Chen, Z., Ye, J., Xu, H., Chen, W., and Long, X. (2019). Niosomal Nanocarriers for Enhanced Skin Delivery of Quercetin with Functions of Anti-Tyrosinase and Antioxidant. Molecules, 24.","DOI":"10.3390\/molecules24122322"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Zhang, S., Li, H.J., Yang, C.M., Liu, L., Sun, X.Y., Wang, J., Chen, S.T., Lu, Y., Hu, M.Q., and Yan, G. (2023). Inflammatory and Immunomodulatory Effects of Tripterygium wilfordii Multiglycoside in Mouse Models of Psoriasis Keratinocytes. Chin. J. Integr. Med.","DOI":"10.1007\/s11655-023-3599-y"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"e967","DOI":"10.1002\/iid3.967","article-title":"Curcumin alleviates imiquimod-induced psoriasis-like inflammation and regulates gut microbiota of mice","volume":"11","author":"Cai","year":"2023","journal-title":"Immun. Inflamm. Dis."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Jia, H.Y., Qiu, H.Y., Zhang, M.D., Hou, J.J., Zhou, M.L., and Wu, Y. (2022). Lenalidomide attenuates IMQ-induced inflammation in a mouse model of psoriasis. Biomed. Pharmacother., 156.","DOI":"10.1016\/j.biopha.2022.113883"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"899","DOI":"10.2147\/IJN.S394957","article-title":"Topical Delivery of ROS-Responsive Methotrexate Prodrug Nanoassemblies by a Dissolvable Microneedle Patch for Psoriasis Therapy","volume":"18","author":"Zhou","year":"2023","journal-title":"Int. J. Nanomed."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Meng, S., Sun, L., Wang, L., Lin, Z., Liu, Z., Xi, L., Wang, Z., and Zheng, Y. (2019). Loading of water-insoluble celastrol into niosome hydrogels for improved topical permeation and anti-psoriasis activity. Colloids Surf. B Biointerfaces, 182.","DOI":"10.1016\/j.colsurfb.2019.110352"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1007\/s11418-022-01664-9","article-title":"Tryptanthrin ameliorates imiquimod-induced psoriasis in mice by suppressing inflammation and oxidative stress via NF-\u03baB\/MAPK\/Nrf2 pathways","volume":"77","author":"Xiong","year":"2023","journal-title":"J. Nat. Med."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/s10787-022-01131-7","article-title":"Development and evaluation emulgel for effective management of the imiquimod-induced psoriasis","volume":"31","author":"Sulthana","year":"2023","journal-title":"Inflammopharmacology"}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/28\/23\/7868\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:34:50Z","timestamp":1760132090000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/28\/23\/7868"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,30]]},"references-count":49,"journal-issue":{"issue":"23","published-online":{"date-parts":[[2023,12]]}},"alternative-id":["molecules28237868"],"URL":"https:\/\/doi.org\/10.3390\/molecules28237868","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,30]]}}}