{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T23:21:31Z","timestamp":1789687291035,"version":"4.0.1"},"reference-count":125,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2023,12,4]],"date-time":"2023-12-04T00:00:00Z","timestamp":1701648000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Major Science and Technology Project of Jilin Province\u2014Major Science and Technology Innovation Project of Sika Deer Industry","award":["20220304002YY"],"award-info":[{"award-number":["20220304002YY"]}]},{"name":"Major Science and Technology Project of Jilin Province\u2014Major Science and Technology Innovation Project of Sika Deer Industry","award":["20220304001YY"],"award-info":[{"award-number":["20220304001YY"]}]},{"name":"Major Science and Technology Project of Jilin Province\u2014Major Science and Technology Innovation Project of Sika Deer Industry","award":["0207-202020043"],"award-info":[{"award-number":["0207-202020043"]}]},{"name":"Special Assistance Project of Jilin Province to Xinjiang Uygur Autonomous Region","award":["20220304002YY"],"award-info":[{"award-number":["20220304002YY"]}]},{"name":"Special Assistance Project of Jilin Province to Xinjiang Uygur Autonomous Region","award":["20220304001YY"],"award-info":[{"award-number":["20220304001YY"]}]},{"name":"Special Assistance Project of Jilin Province to Xinjiang Uygur Autonomous Region","award":["0207-202020043"],"award-info":[{"award-number":["0207-202020043"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Neurological-related disorders are diseases that affect the body\u2019s neurons or peripheral nerve tissue, such as Parkinson\u2019s disease (PD) and Alzheimer\u2019s disease (AD). The development of neurological disorders can cause serious harm to the quality of life and functioning of the patient. The use of traditional therapeutic agents such as dopamine-promoting drugs, anticholinergic drugs, cholinesterase inhibitors, and NMDA receptor antagonists is often accompanied by a series of side effects such as drug resistance, cardiac arrhythmia, liver function abnormalities, and blurred vision. Therefore, there is an urgent need to find a therapeutic drug with a high safety profile and few side effects. Herbal medicines are rich in active ingredients that are natural macromolecules. Ginsenoside is the main active ingredient of ginseng, which has a variety of pharmacological effects and is considered to have potential value in the treatment of human diseases. Modern pharmacological studies have shown that ginsenosides Rg2 and Rh1 have strong pharmacological activities in the nervous system, with protective effects on nerve cells, improved resistance to neuronal injury, modulation of neural activity, resistance to cerebral ischemia\/reperfusion injury, improvement of brain damage after eclampsia hemorrhage, improvement of memory and cognitive deficits, treatment of AD and vascular dementia, alleviation of anxiety, pain, and inhibition of ionic-like behavior. In this article, we searched the pharmacological research literature of Rg2 and Rh1 in the field of neurological diseases, summarized the latest research progress of the two ginsenosides, and reviewed the pharmacological effects and mechanisms of Rg2 and Rh1, which provided a new way of thinking for the research of the active ingredients in ginseng anti-neurological diseases and the development of new drugs.<\/jats:p>","DOI":"10.3390\/molecules28237935","type":"journal-article","created":{"date-parts":[[2023,12,4]],"date-time":"2023-12-04T12:15:14Z","timestamp":1701692114000},"page":"7935","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Research Progress on Effects of Ginsenoside Rg2 and Rh1 on Nervous System and Related Mechanisms"],"prefix":"10.3390","volume":"28","author":[{"given":"Silu","family":"Liu","sequence":"first","affiliation":[{"name":"College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijia","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhao","sequence":"additional","affiliation":[{"name":"College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zong","sequence":"additional","affiliation":[{"name":"College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianming","family":"Li","sequence":"additional","affiliation":[{"name":"College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China"},{"name":"Key Laboratory of Animal Production, Product Quality and Security, Ministry of Education, Jilin Agricultural University, Changchun 130118, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongmei","family":"He","sequence":"additional","affiliation":[{"name":"College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1038\/aps.2013.100","article-title":"Yin and Yang of ginseng pharmacology: Ginsenosides vs. gintonin","volume":"34","author":"Im","year":"2013","journal-title":"Acta Pharmacol. 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