{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T08:05:24Z","timestamp":1788336324703,"version":"build-2803163510"},"reference-count":143,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2023,12,4]],"date-time":"2023-12-04T00:00:00Z","timestamp":1701648000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Youth Program of the National Nature Science Foundation of China","award":["82000556"],"award-info":[{"award-number":["82000556"]}]},{"name":"Youth Program of the National Nature Science Foundation of China","award":["21623109"],"award-info":[{"award-number":["21623109"]}]},{"name":"Youth Program of the National Nature Science Foundation of China","award":["SL2022A04J00501"],"award-info":[{"award-number":["SL2022A04J00501"]}]},{"name":"Fundamental Research Funds for the Central Universities","award":["82000556"],"award-info":[{"award-number":["82000556"]}]},{"name":"Fundamental Research Funds for the Central Universities","award":["21623109"],"award-info":[{"award-number":["21623109"]}]},{"name":"Fundamental Research Funds for the Central Universities","award":["SL2022A04J00501"],"award-info":[{"award-number":["SL2022A04J00501"]}]},{"name":"Guangzhou Basic and Applied Basic Research Project","award":["82000556"],"award-info":[{"award-number":["82000556"]}]},{"name":"Guangzhou Basic and Applied Basic Research Project","award":["21623109"],"award-info":[{"award-number":["21623109"]}]},{"name":"Guangzhou Basic and Applied Basic Research Project","award":["SL2022A04J00501"],"award-info":[{"award-number":["SL2022A04J00501"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Nonalcoholic fatty liver disease (NAFLD) has emerged as the most prevalent chronic liver disorder worldwide, with liver fibrosis (LF) serving as a pivotal juncture in NAFLD progression. Natural products have demonstrated substantial antifibrotic properties, ushering in novel avenues for NAFLD treatment. This study provides a comprehensive review of the potential of natural products as antifibrotic agents, including flavonoids, polyphenol compounds, and terpenoids, with specific emphasis on the role of Baicalin in NAFLD-associated fibrosis. Mechanistically, these natural products have exhibited the capacity to target a multitude of signaling pathways, including Hedgehog, Wnt\/\u03b2-catenin, TGF-\u03b21, and NF-\u03baB. Moreover, they can augment the activities of antioxidant enzymes, inhibit pro-fibrotic factors, and diminish fibrosis markers. In conclusion, this review underscores the considerable potential of natural products in addressing NAFLD-related liver fibrosis through multifaceted mechanisms. Nonetheless, it underscores the imperative need for further clinical investigation to authenticate their effectiveness, offering invaluable insights for future therapeutic advancements in this domain.<\/jats:p>","DOI":"10.3390\/molecules28237936","type":"journal-article","created":{"date-parts":[[2023,12,4]],"date-time":"2023-12-04T12:15:14Z","timestamp":1701692114000},"page":"7936","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Mechanism and Progress of Natural Products in the Treatment of NAFLD-Related Fibrosis"],"prefix":"10.3390","volume":"28","author":[{"given":"Jin-Zhong","family":"Li","sequence":"first","affiliation":[{"name":"Division of Infectious Disease, The First Affiliated Hospital, Jinan University, Guangzhou 510632, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Chen","sequence":"additional","affiliation":[{"name":"General Medicine, The First Affiliated Hospital, Jinan University, Guangzhou 510632, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Ma","sequence":"additional","affiliation":[{"name":"Center for Bioactive Natural Molecules and Innovative Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, China"},{"name":"JNU-HKUST Joint Laboratory for Neuroscience and Innovative Drug Research, College of Pharmacy, Jinan University, Guangzhou 510632, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min-Ran","family":"Li","sequence":"additional","affiliation":[{"name":"Division of Infectious Disease, The First Affiliated Hospital, Jinan University, Guangzhou 510632, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1007\/s12072-020-10094-2","article-title":"The Asian Pacific Association for the Study of the Liver clinical practice guidelines for the diagnosis and management of metabolic associated fatty liver disease","volume":"14","author":"Eslam","year":"2020","journal-title":"Hepatol. 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