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In this study, a novel compound, dimethyl bisphenolate (DMB), was synthesized to investigate its role in ameliorating carbon tetrachloride (CCl4)-induced liver injury through the regulation of oxidative stress-related genes. The structure of DMB was confirmed based on its hydrogen spectrum and mass spectrometry. DMB significantly reduced the high levels of ALT, AST, DBIL, TBIL, ALP, and LDH in a dose-dependent manner in the sera of CCl4-treated rats. The protective effects of DMB on biochemical indicators were similar to those of silymarin. The ROS fluorescence intensity increased in CCl4-treated cells but significantly weakened in DMB-treated cells compared with the controls. DMB significantly increased the content of oxidative stress-related GSH, Nrf2, and GCLC dose-dependently but reduced MDA levels in CCl4-treated cells or the liver tissues of CCl4-treated rats. Moreover, DMB treatment decreased the expression levels of P53 and Bax but increased those of Bcl2. In summary, DMB demonstrated protective effects on CCl4-induced liver injury by regulating oxidative stress-related genes.<\/jats:p>","DOI":"10.3390\/molecules28247989","type":"journal-article","created":{"date-parts":[[2023,12,7]],"date-time":"2023-12-07T05:57:08Z","timestamp":1701928628000},"page":"7989","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Dimethyl Bisphenolate Ameliorates Carbon Tetrachloride-Induced Liver Injury by Regulating Oxidative Stress-Related Genes"],"prefix":"10.3390","volume":"28","author":[{"given":"Rong","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Binzhou Medical University, Yantai 264003, China"},{"name":"Shandong Laboratory of Advanced Materials and Green Manufacturing (Yantai), Yantai 264000, China"},{"name":"College of Life Sciences, Yantai University, Yantai 264005, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanhuan","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Binzhou Medical University, Yantai 264003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxiang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Binzhou Medical University, Yantai 264003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiyan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Binzhou Medical University, Yantai 264003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Binzhou Medical University, Yantai 264003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenjun","family":"Zhao","sequence":"additional","affiliation":[{"name":"College of Life Sciences, Yantai University, Yantai 264005, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pingyu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Binzhou Medical University, Yantai 264003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Breast and Thyroid Surgery, Yantai Affiliated Hospital of Binzhou Medical University, Yantai 264000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youjie","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Binzhou Medical University, Yantai 264003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guiwu","family":"Qu","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Binzhou Medical University, Yantai 264003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8090-2180","authenticated-orcid":false,"given":"Shuyang","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Binzhou Medical University, Yantai 264003, China"},{"name":"Shandong Laboratory of Advanced Materials and Green Manufacturing (Yantai), Yantai 264000, China"},{"name":"College of Life Sciences, Yantai University, Yantai 264005, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,7]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (WHO) (2023, July 28). 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