{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T13:56:42Z","timestamp":1788184602449,"version":"build-2803163510"},"reference-count":43,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T00:00:00Z","timestamp":1702598400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82174343"],"award-info":[{"award-number":["82174343"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["CX20230830"],"award-info":[{"award-number":["CX20230830"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["201803"],"award-info":[{"award-number":["201803"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Hunan graduate research innovation project","award":["82174343"],"award-info":[{"award-number":["82174343"]}]},{"name":"Hunan graduate research innovation project","award":["CX20230830"],"award-info":[{"award-number":["CX20230830"]}]},{"name":"Hunan graduate research innovation project","award":["201803"],"award-info":[{"award-number":["201803"]}]},{"name":"First-class Discipline Project on Chinese Pharmacology of Hunan University of Chinese Medicine","award":["82174343"],"award-info":[{"award-number":["82174343"]}]},{"name":"First-class Discipline Project on Chinese Pharmacology of Hunan University of Chinese Medicine","award":["CX20230830"],"award-info":[{"award-number":["CX20230830"]}]},{"name":"First-class Discipline Project on Chinese Pharmacology of Hunan University of Chinese Medicine","award":["201803"],"award-info":[{"award-number":["201803"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>(1) Background: Ginsenoside Rb1-PLGA nanoparticles (GRb1@PLGA@NPs) represent a novel nanotherapeutic system, yet their therapeutic efficacy and underlying mechanisms for treating heart failure (HF) remain unexplored. This study aims to investigate the potential mechanisms underlying the therapeutic effects of GRb1@PLGA@NPs in HF treatment; (2) Methods: The left anterior descending coronary artery ligation was employed to establish a HF model in Sprague-Dawley rats, along with an in vitro oxidative stress model using H9c2 myocardial cells. Following treatment with GRb1@PLGA@NPs, cardiac tissue pathological changes and cell proliferation were observed. Additionally, the serum levels of biomarkers such as NT-proBNP, TNF-\u03b1, and IL-1\u03b2 were measured, along with the expression of the ROS\/PPAR\u03b1\/PGC1\u03b1 pathway; (3) Results: GRb1@PLGA@NPs effectively ameliorated the pathological status of cardiac tissues in HF rats, mitigated oxidative stress-induced myocardial cell damage, elevated SOD and MMP levels, and reduced LDH, MDA, ROS, NT-proBNP, TNF-\u03b1, and IL-1\u03b2 levels. Furthermore, the expression of PPAR\u03b1 and PGC1\u03b1 proteins was upregulated; (4) Conclusions: GRb1@PLGA@NPs may attenuate myocardial cell injury and treat HF through the ROS\/PPAR\u03b1\/PGC1\u03b1 pathway.<\/jats:p>","DOI":"10.3390\/molecules28248118","type":"journal-article","created":{"date-parts":[[2023,12,18]],"date-time":"2023-12-18T11:28:07Z","timestamp":1702898887000},"page":"8118","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Therapeutic Potential of Ginsenoside Rb1-PLGA Nanoparticles for Heart Failure Treatment via the ROS\/PPAR\u03b1\/PGC1\u03b1 Pathway"],"prefix":"10.3390","volume":"28","author":[{"given":"Lixin","family":"Du","sequence":"first","affiliation":[{"name":"College of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiling","family":"Lu","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyan","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Chinese Medicine, Hunan University of Chinese Medicine, Changsha 410208, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengxin","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Chinese Medicine, Hunan University of Chinese Medicine, Changsha 410208, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifei","family":"Xiao","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihua","family":"Guo","sequence":"additional","affiliation":[{"name":"College of Chinese Medicine, Hunan University of Chinese Medicine, Changsha 410208, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya","family":"Li","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Mansur, A.d.P., Pereira-Barretto, A.C., del Carlo, C.H., Avakian, S.D., Nakagawa, N.K., Cesar, L.A.M., and Bocchi, E.A. 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