{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T12:11:09Z","timestamp":1790424669325,"version":"4.1.0"},"reference-count":22,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T00:00:00Z","timestamp":1703203200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Natural Science Foundation of China","award":["82003570"],"award-info":[{"award-number":["82003570"]}]},{"name":"National Natural Science Foundation of China","award":["2015B010109004"],"award-info":[{"award-number":["2015B010109004"]}]},{"name":"Science and Technology Planning Project of Guangdong Province","award":["82003570"],"award-info":[{"award-number":["82003570"]}]},{"name":"Science and Technology Planning Project of Guangdong Province","award":["2015B010109004"],"award-info":[{"award-number":["2015B010109004"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Selective butyrylcholinesterase inhibitors are considered promising drug candidates for the treatment of Alzheimer\u2019s disease. In this work, one rivastigmine\u2013bambuterol hybrid (MTR-1) and fourteen of its analogues were synthesized, purified, and characterized. In vitro cholinesterase assays showed that all the compounds were more potent inhibitors of BChE when compared to AChE. Further investigations indicated that MTR-3 (IC50(AChE) &gt; 100,000 nM, IC50(BChE) = 78 nM) was the best compound in the series, showing high butyrylcholinesterase selectivity and inhibition potency, the potential to permeate the blood\u2013brain barrier, and longer-lasting BChE inhibition than bambuterol. These compounds could be used to discover novel specific BChE inhibitors for the treatment of Alzheimer\u2019s disease.<\/jats:p>","DOI":"10.3390\/molecules29010072","type":"journal-article","created":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T04:44:40Z","timestamp":1703220280000},"page":"72","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Rivastigmine\u2013Bambuterol Hybrids as Selective Butyrylcholinesterase Inhibitors"],"prefix":"10.3390","volume":"29","author":[{"given":"Jie","family":"Wu","sequence":"first","affiliation":[{"name":"School of Food & Pharmaceutical Engineering, Zhaoqing University, Zhaoqing 526061, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zekai","family":"Tan","sequence":"additional","affiliation":[{"name":"Institute of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7957-2025","authenticated-orcid":false,"given":"Marco","family":"Pistolozzi","sequence":"additional","affiliation":[{"name":"International School, Jinan University, Guangzhou 510632, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Tan","sequence":"additional","affiliation":[{"name":"Post-Doctoral Innovation Site, Jinan University Affiliation, Yuanzhi Health-Tech Inc., Hengqin District, Zhuhai 519000, China"},{"name":"Kesi (Shandong) Innovation Service Inc., Heze Modern Medical Port, Mudan District, Heze 274009, China"},{"name":"Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Bandar Sunway 47500, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.bioorg.2018.03.003","article-title":"Novel carbamate derivatives as selective butyrylcholinesterase inhibitors","volume":"78","author":"Bajda","year":"2018","journal-title":"Bioorganic Chem."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.bioorg.2018.06.006","article-title":"Synthesis and cholinesterase inhibitory activity of new 2-benzofuran carboxamide-benzylpyridinum salts","volume":"80","author":"Abedinifar","year":"2018","journal-title":"Bioorganic Chem."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Wu, C., Tu, Y.B., Li, Z., and Li, Y.F. 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