{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T10:44:13Z","timestamp":1789382653626,"version":"build-2803163510"},"reference-count":115,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T00:00:00Z","timestamp":1703203200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100014890","name":"Qilu University of Technology","doi-asserted-by":"publisher","award":["2022PY047"],"award-info":[{"award-number":["2022PY047"]}],"id":[{"id":"10.13039\/501100014890","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014890","name":"Qilu University of Technology","doi-asserted-by":"publisher","award":["2022JBZ02-05"],"award-info":[{"award-number":["2022JBZ02-05"]}],"id":[{"id":"10.13039\/501100014890","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014890","name":"Qilu University of Technology","doi-asserted-by":"publisher","award":["41907315"],"award-info":[{"award-number":["41907315"]}],"id":[{"id":"10.13039\/501100014890","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Natural Science Foundation of China","award":["2022PY047"],"award-info":[{"award-number":["2022PY047"]}]},{"name":"National Natural Science Foundation of China","award":["2022JBZ02-05"],"award-info":[{"award-number":["2022JBZ02-05"]}]},{"name":"National Natural Science Foundation of China","award":["41907315"],"award-info":[{"award-number":["41907315"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Aristolochic acids (AAs) are a toxic substance present in certain natural plants. Direct human exposure to these plants containing AAs leads to a severe and irreversible condition known as aristolochic acid nephropathy (AAN). Additionally, AAs accumulation in the food chain through environmental mediators can trigger Balkan endemic nephropathy (BEN), an environmental variant of AAN. This paper presents a concise overview of the oncogenic pathways associated with AAs and explores the various routes of environmental exposure to AAs. The detection and removal of AAs in natural plants, drugs, and environmental and biological samples were classified and summarized, and the advantages and disadvantages of the various methods were analyzed. It is hoped that this review can provide effective insights into the detection and removal of AAs in the future.<\/jats:p>","DOI":"10.3390\/molecules29010081","type":"journal-article","created":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T04:44:40Z","timestamp":1703220280000},"page":"81","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Detection and Removal of Aristolochic Acid in Natural Plants, Pharmaceuticals, and Environmental and Biological Samples: A Review"],"prefix":"10.3390","volume":"29","author":[{"given":"Changhong","family":"Wang","sequence":"first","affiliation":[{"name":"School of Environmental Science and Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250353, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunchao","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Environmental Science and Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250353, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jintai","family":"Han","sequence":"additional","affiliation":[{"name":"School of Environmental Science and Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250353, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenying","family":"Li","sequence":"additional","affiliation":[{"name":"College of Geography and Environment, Shandong Normal University, Jinan 250000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Sun","sequence":"additional","affiliation":[{"name":"School of Environmental Science and Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250353, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinan","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Fine Chemicals in Universities of Shandong, Jinan Engineering Laboratory for Multi-Scale Functional Materials, School of Chemistry and Chemical Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250353, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Kili\u015b-Pstrusi\u0144ska, K., and Wiela-Hoje\u0144ska, A. (2021). Nephrotoxicity of Herbal Products in Europe-A Review of an Underestimated Problem. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22084132"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1007\/s00467-019-04397-2","article-title":"Nephrotoxins and nephrotoxic acute kidney injury","volume":"35","author":"Uber","year":"2020","journal-title":"Pediatr. Nephrol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1038\/ki.2008.129","article-title":"Aristolochic acid nephropathy: A worldwide problem","volume":"74","author":"Debelle","year":"2008","journal-title":"Kidney Int."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.jep.2009.05.028","article-title":"Local uses of Aristolochia species and content of nephrotoxic aristolochic acid 1 and 2-A global assessment based on bibliographic sources","volume":"125","author":"Heinrich","year":"2009","journal-title":"J. Ethnopharmacol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/0140-6736(93)92984-2","article-title":"Rapidly progressive interstitial renal fibrosis in young-women\u2014Association with slimming regimen including chinese herbs","volume":"341","author":"Vanherweghem","year":"1993","journal-title":"Lancet"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1016\/S0272-6386(99)70159-9","article-title":"On a nephratoxic and carcinogenic slimming regimen","volume":"33","year":"1999","journal-title":"Am. J. Kidney Dis."},{"key":"ref_7","first-page":"2025","article-title":"Detection of DNA Adducts Formed by Aristolochic Acid in Renal Tissue from Patients with Chinese Herbs Nephropathy","volume":"56","author":"Schmeiser","year":"1996","journal-title":"Cancer Res."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"E27","DOI":"10.1053\/ajkd.2001.29576","article-title":"Thrombosis associated with cytomegalovirus infection in patients with ANCA-positive vasculitis","volume":"38","author":"Wolf","year":"2001","journal-title":"Am. J. Kidney Dis."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"123","DOI":"10.4081\/aiua.2022.1.123","article-title":"Aristolochic acid: What urologists should know","volume":"94","author":"Thangavelu","year":"2022","journal-title":"Arch. Ital. Urol. Androl."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"648","DOI":"10.3389\/fphar.2019.00648","article-title":"Systematic Overview of Aristolochic Acids: Nephrotoxicity, Carcinogenicity, and Underlying Mechanisms","volume":"10","author":"Han","year":"2019","journal-title":"Front. Pharmacol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.fct.2016.03.017","article-title":"Predicting points of departure for risk assessment based on in vitro cytotoxicity data and physiologically based kinetic (PBK) modeling: The case of kidney toxicity induced by aristolochic acid I","volume":"92","author":"Abdullah","year":"2016","journal-title":"Food Chem. Toxicol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"197ra101","DOI":"10.1126\/scitranslmed.3006086","article-title":"Genome-Wide Mutational Signatures of Aristolochic Acid and Its Application as a Screening Tool","volume":"5","author":"Poon","year":"2013","journal-title":"Sci. Transl. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S1470-2045(08)70286-9","article-title":"A review of human carcinogens\u2014Part A: Pharmaceuticals","volume":"10","author":"Grosse","year":"2009","journal-title":"Lancet Oncol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"eaan6446","DOI":"10.1126\/scitranslmed.aan6446","article-title":"Aristolochic acids and their derivatives are widely implicated in liver cancers in Taiwan and throughout Asia","volume":"9","author":"Ng","year":"2017","journal-title":"Sci. Transl. Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1002\/hep.30863","article-title":"The Mutational Features of Aristolochic Acid-Induced Mouse and Human Liver Cancers","volume":"71","author":"Lu","year":"2020","journal-title":"Hepatology"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"840961","DOI":"10.3389\/fgene.2022.840961","article-title":"Integration of Transcriptomic and Metabolomic Data to Compare the Hepatotoxicity of Neonatal and Adult Mice Exposed to Aristolochic Acid\u2160","volume":"13","author":"Fang","year":"2022","journal-title":"Front. Genet."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1053\/j.ajkd.2008.05.024","article-title":"Balkan nephropathy: Evolution of our knowledge","volume":"52","author":"Bamias","year":"2008","journal-title":"Am. J. Kidney Dis."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Petrescu, A.M., Lukinich-Gruia, A.T., Paunescu, V., and Ilia, G. (2019). A Theoretical Study of the Molecular Coupled Structures of Aristolochic Acids and Humic Acid, Potential Environmental Contaminants. Chem. Biodivers., 16.","DOI":"10.1002\/cbdv.201900406"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"469","DOI":"10.7326\/0003-4819-158-6-201303190-00006","article-title":"The Epidemiology, Diagnosis, and Management of Aristolochic Acid Nephropathy A Narrative Review","volume":"158","author":"Gokmen","year":"2013","journal-title":"Ann. Intern. Med."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.semnephrol.2019.02.007","article-title":"Balkan Endemic Nephropathy and the Causative Role of Aristolochic Acid","volume":"39","author":"Dika","year":"2019","journal-title":"Semin. Nephrol."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Kang, Y.C., Chen, M.H., Lin, C.Y., Lin, C.Y., and Chen, Y.T. (2021). Aristolochic acid-associated urinary tract cancers: An updated meta-analysis of risk and oncologic outcomes after surgery and systematic review of molecular alterations observed in human studies. Ther. Adv. Drug Saf., 12.","DOI":"10.1177\/2042098621997727"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Anger, E.E., Yu, F., and Li, J. (2020). Aristolochic Acid-Induced Nephrotoxicity: Molecular Mechanisms and Potential Protective Approaches. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21031157"},{"key":"ref_23","unstructured":"Nortier, J.L., Vanherweghem, J.-L., and Jelakovic, B. (2022). Tubulointerstitial Nephritis, Springer."},{"key":"ref_24","first-page":"141","article-title":"Chemical and molecular basis of the carcinogenicity of Aristolochia plants","volume":"12","author":"Schmeiser","year":"2009","journal-title":"Curr. Opin. Drug Discov. Dev."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1093\/carcin\/7.9.1543","article-title":"Nudease Pl-mediated enhancement of sensitivity of 32P-postlabeling test for structurally diverse DNA adducts","volume":"7","author":"Reddy","year":"1986","journal-title":"Carcinogenesis"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1093\/carcin\/11.2.313","article-title":"AristolocMc acid binds covafleettly to tlhe exocycMc ammo gromp off perime emclleoitides mDNA","volume":"11","author":"Pfau","year":"1990","journal-title":"Carcinogenesis"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1093\/carcin\/11.9.1627","article-title":"32P-PostIlaIbeIlMinig amalysns off tihe DNA addmdts ffonnnied by aristoIocMc acid I and II","volume":"11","author":"Pfau","year":"1990","journal-title":"Carcinogenesis"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1093\/nar\/gkp815","article-title":"DNA adducts of aristolochic acid II: Total synthesis and site-specific mutagenesis studies in mammalian cells","volume":"38","author":"Attaluri","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"12129","DOI":"10.1073\/pnas.0701248104","article-title":"Aristolochic acid and the etiology of endemic (Balkan) nephropathy","volume":"104","author":"Grollman","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1093\/mutage\/17.4.265","article-title":"Aristolochic acid as a probable human cancer hazard in herbal remedies: A review","volume":"17","author":"Arlt","year":"2002","journal-title":"Mutagenesis"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Jadot, I., Decleves, A.E., Nortier, J., and Caron, N. (2017). An Integrated View of Aristolochic Acid Nephropathy: Update of the Literature. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18020297"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Xian, Z., Tian, J.Z., Zhang, Y.S., Meng, J., Zhao, Y., Li, C.Y., Yi, Y., Han, J.Y., Liu, S.Y., and Wang, L.M. (2021). Study on the potential nephrotoxicity and mutagenicity of aristolochic acid IVa and its mechanism. Biomed. Pharmacother., 142.","DOI":"10.1016\/j.biopha.2021.112081"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1038\/s41568-022-00494-x","article-title":"Aristolochic acid-associated cancers: A public health risk in need of global action","volume":"22","author":"Das","year":"2022","journal-title":"Nat. Rev. Cancer"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1038\/sj.jes.7500489","article-title":"Evaluation of the hypothesis that Balkan endemic nephropathy is caused by drinking water exposure to contaminants leaching from Pliocene coal deposits","volume":"16","author":"Voice","year":"2006","journal-title":"J. Expo. Sci. Environ. Epidemiol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1021\/acs.jafc.5b05089","article-title":"Uptake and Accumulation of Nephrotoxic and Carcinogenic Aristolochic Acids in Food Crops Grown in Aristolochia clematitis-Contaminated Soil and Water","volume":"64","author":"Li","year":"2016","journal-title":"J. Agric. Food Chem."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"11468","DOI":"10.1021\/acs.jafc.8b04770","article-title":"Aristolochic Acids as Persistent Soil Pollutants: Determination of Risk for Human Exposure and Nephropathy from Plant Uptake","volume":"66","author":"Li","year":"2018","journal-title":"J. Agric. Food Chem."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"5928","DOI":"10.1021\/acs.jafc.6b02203","article-title":"Quantitation of Aristolochic Acids in Corn, Wheat Grain, and Soil Samples Collected in Serbia: Identifying a Novel Exposure Pathway in the Etiology of Balkan Endemic Nephropathy","volume":"64","author":"Chan","year":"2016","journal-title":"J. Agric. Food Chem."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s10653-012-9477-8","article-title":"Possible health impacts of naturally occurring uptake of aristolochic acids by maize and cucumber roots: Links to the etiology of endemic (Balkan) nephropathy","volume":"35","author":"Pavlovic","year":"2013","journal-title":"Environ. Geochem. Health"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1021\/acsagscitech.1c00144","article-title":"Determination of Aristolochic Acids in Soil, Water, and Herbal Plants in Medicinal Plant Cultivation Areas: An Emerging Environmental Contaminant Worth Concerning","volume":"1","author":"Chan","year":"2021","journal-title":"ACS Agric. Sci. Technol."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Zhang, J., Wang, Y., Wang, C., Li, K., Tang, W., Sun, J., and Wang, X. (2022). Uptake, Translocation, and Fate of Carcinogenic Aristolochic Acid in Typical Vegetables in Soil-Plant Systems. Molecules, 27.","DOI":"10.3390\/molecules27238271"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10653-013-9515-1","article-title":"Organic compounds in water extracts of coal: Links to Balkan endemic nephropathy","volume":"36","author":"Maharaj","year":"2014","journal-title":"Environ. Geochem. Health"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1021\/acs.est.9b05337","article-title":"Occurrence and Environmental Stability of Aristolochic Acids in Groundwater Collected from Serbia: Links to Human Exposure and Balkan Endemic Nephropathy","volume":"54","author":"Tung","year":"2020","journal-title":"Environ. Sci. Technol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"134111","DOI":"10.1016\/j.chemosphere.2022.134111","article-title":"Aristolochic acid I as an emerging biogenic contaminant involved in chronic kidney diseases: A comprehensive review on exposure pathways, environmental health issues and future challenges","volume":"297","author":"Nortier","year":"2022","journal-title":"Chemosphere"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0378-4347(01)00416-9","article-title":"High-performance liquid chromatographic determination for aristolochic acid in medicinal plants and slimming products","volume":"766","author":"Lee","year":"2001","journal-title":"J. Chromatogr. B"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"444","DOI":"10.5796\/electrochemistry.82.444","article-title":"Determination of Aristolochic Acids I and II in Herbal Medicines by High-performance Liquid Chromatography with Electrochemical Detection","volume":"82","author":"Kotani","year":"2014","journal-title":"Electrochemistry"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.chroma.2007.06.055","article-title":"A sensitivity enhanced high-performance liquid chromatography fluorescence method for the detection of nephrotoxic and carcinogenic aristolochic acid in herbal medicines","volume":"1164","author":"Chan","year":"2007","journal-title":"J. Chromatogr. A"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/j.jchromb.2009.02.054","article-title":"Determination of aristolochic acid I in rat urine and plasma by high-performance liquid chromatography with fluorescence detection","volume":"877","author":"Yue","year":"2009","journal-title":"J. Chromatogr. B Anal. Technol. Biomed. Life Sci."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"5859","DOI":"10.1021\/jf501609j","article-title":"Determination of Aristolochic Acids by High-Performance Liquid Chromatography with Fluorescence Detection","volume":"62","author":"Wang","year":"2014","journal-title":"J. Agric. Food Chem."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.foodchem.2018.05.052","article-title":"Cooking methods employing natural anti-oxidant food additives effectively reduced concentration of nephrotoxic and carcinogenic aristolochic acids in contaminated food grains","volume":"264","author":"Li","year":"2018","journal-title":"Food Chem."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"12365","DOI":"10.1021\/acs.analchem.3c01874","article-title":"Fabrication of a Simple and Efficient HPLC Reduction Column for Online Conversion of Aristolochic Acids to Aristolactams Prior to Sensitive Fluorescence Detection","volume":"95","author":"Chin","year":"2023","journal-title":"Anal. Chem."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"6338","DOI":"10.1039\/C6AN01539E","article-title":"Phytochemical profiling in single plant cell by high performance liquid chromatography-mass spectrometry","volume":"141","author":"Yuan","year":"2016","journal-title":"Analyst"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.jasms.2006.11.010","article-title":"Liquid chromatography-tandem mass spectrometry analysis of the DNA adducts of aristolochic acids","volume":"18","author":"Chan","year":"2007","journal-title":"J. Am. Soc. Mass Spectrom."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1021\/acs.chemrestox.5b00021","article-title":"Quantification of aristolochic acid-RNA adducts in the urine of aristolochic acid-treated rats by liquid chromatography-tandem mass spectrometry","volume":"28","author":"Leung","year":"2015","journal-title":"Chem. Res. Toxicol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"4163","DOI":"10.1007\/s10653-021-00903-4","article-title":"Aristolochic acid I: An investigation into the role of food crops contamination, as a potential natural exposure pathway","volume":"43","author":"Draghia","year":"2021","journal-title":"Environ. Geochem. Health"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1021\/acs.chemrestox.0c00454","article-title":"Quantitation of Protein Adducts of Aristolochic Acid I by Liquid Chromatography-Tandem Mass Spectrometry: A Novel Method for Biomonitoring Aristolochic Acid Exposure","volume":"34","author":"Chan","year":"2021","journal-title":"Chem. Res. Toxicol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1002\/rcm.611","article-title":"Detecting aristolochic acids in herbal remedies by liquid chromatography\/serial mass spectrometry","volume":"16","author":"Kite","year":"2002","journal-title":"Rapid Commun. Mass Spectrom."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/S0731-7085(03)00310-8","article-title":"Analysis of aristolochic acid in nine sources of Xixin, a traditional Chinese medicine, by liquid chromatography\/atmospheric pressure chemical ionization\/tandem mass spectrometry","volume":"33","author":"Jong","year":"2003","journal-title":"J. Pharm. Biomed. Anal."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1002\/rcm.4516","article-title":"Liquid chromatography\/mass spectrometry for investigating the biochemical effects induced by aristolochic acid in rats: The plasma metabolome","volume":"24","author":"Lin","year":"2010","journal-title":"Rapid Commun. Mass Spectrom."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1002\/bmc.1267","article-title":"A liquid chromatography\/tandem mass spectrometry method for determination of aristolochic acid-I in rat plasma","volume":"24","author":"Liu","year":"2010","journal-title":"Biomed. Chromatogr."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1021\/tx3000889","article-title":"Biomonitoring of Aristolactam-DNA Adducts in Human Tissues Using Ultra-Performance Liquid Chromatography\/Ion-Trap Mass Spectrometry","volume":"25","author":"Yun","year":"2012","journal-title":"Chem. Res. Toxicol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1080\/19440049.2014.892215","article-title":"Quantification of aristolochic acids I and II in herbal dietary supplements by ultra-high-performance liquid chromatography-multistage fragmentation mass spectrometry","volume":"31","author":"Vaclavik","year":"2014","journal-title":"Food Addit. Contam. Part A\u2014Chem. Anal. Control Expo. Risk Assess."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.foodchem.2019.03.073","article-title":"Development of a novel liquid chromatography-tandem mass spectrometric method for aristolochic acids detection: Application in food and agricultural soil analyses","volume":"289","author":"Chan","year":"2019","journal-title":"Food Chem."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"e8547","DOI":"10.1002\/rcm.8547","article-title":"Liquid chromatography-tandem mass spectrometry analysis of aristolochic acids in soil samples collected from Serbia: Link to Balkan endemic nephropathy","volume":"34","author":"Chan","year":"2020","journal-title":"Rapid Commun. Mass Spectrom."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"8823596","DOI":"10.1155\/2020\/8823596","article-title":"Rapid Analysis of Aristolochic Acid Analogues in Traditional Chinese Patent Medicine by LC-MS\/MS","volume":"2020","author":"Liu","year":"2020","journal-title":"J. Anal. Methods Chem."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"e4652","DOI":"10.1002\/jms.4652","article-title":"Analysis of aristolochic acids in Houttuynia cordataby liquid chromatography-tandem mass spectrometry","volume":"56","author":"Chan","year":"2021","journal-title":"J. Mass Spectrom."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Yu, X., Gao, Y., Xu, Y., Guo, X., Guo, L., Tan, T., Liu, F., and Wan, Y.Q. (2022). Study of the Contents of Analogues of Aristolochic Acid in Houttuynia cordata by Ultra-High Performance Liquid Chromatography Tandem Mass Spectrometry. Foods, 11.","DOI":"10.3390\/foods11030302"},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Ji, H., Zhang, G., and Zhou, X. (2023). Rapid simultaneous determination of thirteen aristolochic acids analogs in Aristolochiaceae plants by Ultra-High-Performance liquid Chromatography-tandem mass spectrometry in dynamic multiple reaction monitoring mode. J. Chromatogr. B Anal. Technol. Biomed. Life Sci., 1225.","DOI":"10.1016\/j.jchromb.2023.123753"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"5269545","DOI":"10.1155\/2022\/5269545","article-title":"Rapid and Simultaneous Quantification of Six Aristolochic Acids and Two Lignans in Asari Radix et Rhizoma Using Ultra-Performance Liquid Chromatography-Triple Quadrupole Tandem Mass Spectrometry","volume":"2022","author":"Liu","year":"2022","journal-title":"J. Anal. Methods Chem."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Liu, J.L., Xu, C.L., Yang, T., Hu, Z.R., Zhang, Z.Q., and Feng, G.D. (2019). Developed a novel sensor based on fluorescent graft conjugated polymer for the determination of aristolochic acid in traditional Chinese medicine. Spectrochim. Acta Part A\u2014Mol. Biomol. Spectrosc., 222.","DOI":"10.1016\/j.saa.2019.117239"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1002\/ejic.202100119","article-title":"A Novel Luminescent Metal-Organic Framework as a Remarkable Sensor for Detecting Aristolochic Acids in Biological Fluids","volume":"2021","author":"Song","year":"2021","journal-title":"Eur. J. Inorg. Chem."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"124869","DOI":"10.1016\/j.talanta.2023.124869","article-title":"Europium chelate-anionic exchange functionalized covalent organic frameworks for the sensing of aristolochic acid a in humans and sulfamethoxazole\/trimethoprim in surface water","volume":"265","author":"Shen","year":"2023","journal-title":"Talanta"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0021-9673(04)01336-6","article-title":"Rapid determination of aristolochic acid I and II in Aristolochia plants from different regions by \u03b2-cyclodextrin-modified capillary zone electrophoresis","volume":"1049","author":"Li","year":"2004","journal-title":"J. Chromatogr. A"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1002\/elan.201800893","article-title":"Glassy Carbon Electrode Modified via Molybdenum Disulfide Decorated Multiwalled Carbon Nanotubes for Sensitive Voltammetric Detection of Aristolochic Acids","volume":"31","author":"Wang","year":"2019","journal-title":"Electroanalysis"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"121550","DOI":"10.1016\/j.jhazmat.2019.121550","article-title":"Soft-templated mesoporous carbon-modified glassy carbon electrode for sensitive and selective detection of aristolochic acids","volume":"385","author":"Wang","year":"2020","journal-title":"J. Hazard. Mater."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"5868170","DOI":"10.1155\/2016\/5868170","article-title":"Detection of Melamine in Soybean Meal Using Near-Infrared Microscopy Imaging with Pure Component Spectra as the Evaluation Criteria","volume":"2016","author":"Yang","year":"2016","journal-title":"J. Spectrosc."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"5118","DOI":"10.1039\/C9AY01531K","article-title":"1D convolutional neural network for the discrimination of aristolochic acids and their analogues based on near-infrared spectroscopy","volume":"11","author":"Chen","year":"2019","journal-title":"Anal. Methods"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.jpba.2015.04.003","article-title":"Rapid authentication of Cordyceps by lateral flow dipstick","volume":"111","author":"Wong","year":"2015","journal-title":"J. Pharm. Biomed. Anal."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1016\/j.biotechadv.2014.07.004","article-title":"A renaissance in herbal medicine identification: From morphology to DNA","volume":"32","author":"Chen","year":"2014","journal-title":"Biotechnol. Adv."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"11318","DOI":"10.1038\/srep11318","article-title":"An integrated system for identifying the hidden assassins in traditional medicines containing aristolochic acids","volume":"5","author":"Wu","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.apsb.2017.10.001","article-title":"Biomonitoring for traditional herbal medicinal products using DNA metabarcoding and single molecule, real-time sequencing","volume":"8","author":"Xin","year":"2018","journal-title":"Acta Pharm. Sin. B"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"12188","DOI":"10.1038\/s41598-022-16528-1","article-title":"A PCR-lateral flow immunochromatographic assay (PCR-LFA) for detecting Aristolochia species, the plants responsible for aristolochic acid nephropathy","volume":"12","author":"Thongkhao","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"108307","DOI":"10.1016\/j.microc.2022.108307","article-title":"Development of two immunochromatographic test strips based on gold nanospheres and gold nanoflowers for the rapid and simultaneous detection of aflatoxin B1 and aristolochic acid a in dual-use medicinal and food ingredients","volume":"186","author":"Chen","year":"2023","journal-title":"Microchem. J."},{"key":"ref_83","first-page":"1110","article-title":"Research progress on Chinese herbal medicine fermentation and profile of active substances derived","volume":"44","author":"Ai","year":"2019","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1128\/aem.01601-22","article-title":"Identification of a Novel Coumarins Biosynthetic Pathway in the Endophytic Fungus Fusarium oxysporum GU-7 with Antioxidant Activity","volume":"89","author":"Sun","year":"2023","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"4863","DOI":"10.1128\/AEM.68.10.4863-4870.2002","article-title":"Biotransformation of 2-benzoxazolinone and 2-hydroxy-1,4-benzoxazin-3-one by endophytic fungi isolated from Aphelandra tetragona","volume":"68","author":"Zikmundova","year":"2002","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1111\/lam.13086","article-title":"Characterization of the fungitoxic activity on Botrytis cinerea of the aristolochic acids I and II","volume":"68","author":"Melo","year":"2019","journal-title":"Lett. Appl. Microbiol."},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Wang, X., Jiang, D., Shi, Q., Ren, G., and Liu, C. (2022). Microbial degradation of aristolochic acid I by endophytic fungus A.h-Fs-1 of Asarum heterotropoides. Front. Microbiol., 13.","DOI":"10.3389\/fmicb.2022.917117"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"3047","DOI":"10.1002\/jssc.201900554","article-title":"Isolation of aristolochic acid I from herbal plant using molecular imprinted polymer composited ionic liquid-based zeolitic imidazolate framework-67","volume":"42","author":"Fang","year":"2019","journal-title":"J. Sep. Sci."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Zhang, M.M., Liu, H.Y., Han, Y.M., Bai, L.G., and Yan, H.Y. (2020). On-line enrichment and determination of aristolochic acid in medicinal plants using a MOF-based composite monolith as adsorbent. J. Chromatogr. B\u2014Anal. Technol. Biomed. Life Sci., 1159.","DOI":"10.1016\/j.jchromb.2020.122343"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"122705","DOI":"10.1016\/j.cej.2019.122705","article-title":"Interaction between chlortetracycline and calcium-rich biochar: Enhanced removal by adsorption coupled with flocculation","volume":"382","author":"Xu","year":"2020","journal-title":"Chem. Eng. J."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"462155","DOI":"10.1016\/j.chroma.2021.462155","article-title":"Metal-organic framework grafted with melamine for the selective recognition and miniaturized solid phase extraction of aristolochic acid I from traditional Chinese medicine","volume":"1647","author":"Shu","year":"2021","journal-title":"J. Chromatogr. A"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"135074","DOI":"10.1016\/j.foodchem.2022.135074","article-title":"A dispersive solid-phase extraction method for the determination of Aristolochic acids in Houttuynia cordata based on MIL-101(Fe): An analytes-oriented adsorbent selection design","volume":"407","author":"Cheng","year":"2023","journal-title":"Food Chem."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.chroma.2019.06.043","article-title":"Preparation of magnetic molecularly imprinted polymers functionalized carbon nanotubes for highly selective removal of aristolochic acid","volume":"1602","author":"Li","year":"2019","journal-title":"J. Chromatogr. A"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"461382","DOI":"10.1016\/j.chroma.2020.461382","article-title":"Adenine-coated magnetic multiwalled carbon nanotubes for the selective extraction of aristolochic acids based on multiple interactions","volume":"1627","author":"Shu","year":"2020","journal-title":"J. Chromatogr. A"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.jiec.2016.08.023","article-title":"The properties and applications of helical carbon fibers and related materials: A review","volume":"44","author":"Raghubanshi","year":"2016","journal-title":"J. Ind. Eng. Chem."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.cej.2017.01.051","article-title":"Single-helix carbon microcoils prepared via Fe(III)-osmotically induced shape transformation of zucchini (Cucurbita pepo L.) for enhanced adsorption and antibacterial activities","volume":"315","author":"Liu","year":"2017","journal-title":"Chem. Eng. J."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.chroma.2018.05.037","article-title":"Hybrid-type carbon microcoil-chitosan composite for selective extraction of aristolochic acid I from Aristolochiaceae medicinal plants","volume":"1561","author":"Shu","year":"2018","journal-title":"J. Chromatogr. A"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1021\/acs.chemrev.8b00171","article-title":"Molecularly Imprinted Polymers","volume":"119","author":"BelBruno","year":"2019","journal-title":"Chem. Rev."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"7282415","DOI":"10.1155\/2020\/7282415","article-title":"Synthesis of Diazepam-Imprinted Polymers with Two Functional Monomers in Chloroform Using a Bulk Polymerization Method","volume":"2020","author":"Hasanah","year":"2020","journal-title":"J. Chem."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"3075","DOI":"10.1002\/pat.4428","article-title":"Synthesis of prednisolone molecularly imprinted polymer nanoparticles by precipitation polymerization","volume":"29","author":"Phungpanya","year":"2018","journal-title":"Polym. Adv. Technol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/j.electacta.2016.06.098","article-title":"Novel Pva Proton Conducting Membranes Doped with Polyaniline Generated by in-Situ Polymerization","volume":"211","author":"Albu","year":"2016","journal-title":"Electrochim. Acta"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.talanta.2016.10.014","article-title":"Preparation and adsorption properties of molecularly imprinted polymer via RAFT precipitation polymerization for selective removal of aristolochic acid I","volume":"162","author":"Xiao","year":"2017","journal-title":"Talanta"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"131250","DOI":"10.1016\/j.foodchem.2021.131250","article-title":"Thermosensitive and magnetic molecularly imprinted polymers for selective recognition and extraction of aristolochic acid","volume":"372","author":"Xiong","year":"2022","journal-title":"Food Chem."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.msec.2018.12.057","article-title":"Combined magnetic porous molecularly imprinted polymers and deep eutectic solvents for efficient and selective extraction of aristolochic acid I and II from rat urine","volume":"97","author":"Ge","year":"2019","journal-title":"Mater. Sci. Eng. C\u2014Mater. Biol. Appl."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"2791","DOI":"10.1002\/jssc.201700116","article-title":"Selective analysis of aristolochic acid I in herbal medicines by dummy molecularly imprinted solid-phase extraction and HPLC","volume":"40","author":"Ge","year":"2017","journal-title":"J. Sep. Sci."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"104463","DOI":"10.1016\/j.microc.2019.104463","article-title":"Dummy molecularly imprinted silica materials for effective removal of aristolochic acid I from kaempfer dutchmanspipe root extract","volume":"152","author":"Wang","year":"2020","journal-title":"Microchem. J."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"2421","DOI":"10.1002\/elps.201400127","article-title":"Electromembrane extraction--three-phase electrophoresis for future preparative applications","volume":"35","author":"Gjelstad","year":"2014","journal-title":"Electrophoresis"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"460424","DOI":"10.1016\/j.chroma.2019.460424","article-title":"Electromembrane extraction of aristolochic acids: New insights in separation of bioactive ingredients of traditional Chinese medicines","volume":"1608","author":"Yan","year":"2019","journal-title":"J. Chromatogr. A"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1093\/jaoac\/86.2.412","article-title":"Fast and Easy Multiresidue Method Employing Acetonitrile Extraction\/Partitioning and \u201cDispersive Solid-Phase Extraction\u201d for the Determination of Pesticide Residues in Produce","volume":"86","author":"Anastassiades","year":"2003","journal-title":"J. AOAC Int."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"35597","DOI":"10.1039\/D0RA90099K","article-title":"Correction: QuEChERS pretreatment combined with high-performance liquid chromatography-tandem mass spectrometry for determination of aristolochic acids I and II in Chinese herbal patent medicines","volume":"10","author":"Zhang","year":"2020","journal-title":"RSC Adv."},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Pattiram, P.D., Abas, F., Suleiman, N., Mohamad Azman, E., and Chong, G.H. (2022). Edible oils as a co-extractant for the supercritical carbon dioxide extraction of flavonoids from propolis. PLoS ONE, 17.","DOI":"10.1371\/journal.pone.0266673"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.seppur.2010.02.016","article-title":"Removal of toxic aristolochic acid components from Aristolochia plants by supercritical fluid extraction","volume":"72","author":"Liang","year":"2010","journal-title":"Sep. Purif. Technol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"137528","DOI":"10.1016\/j.scitotenv.2020.137528","article-title":"Remediation of aristolochic acid-contaminated soil by an effective advanced oxidation process","volume":"720","author":"Chan","year":"2020","journal-title":"Sci. Total Environ."},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"Chen, P., Li, X., Yan, X., and Tian, M. (2021). Solid-Phase Extraction of Aristolochic Acid I from Natural Plant Using Dual Ionic Liquid-Immobilized ZIF-67 as Sorbent. Separations, 8.","DOI":"10.3390\/separations8020022"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.chroma.2019.01.008","article-title":"Dual ionic liquid-immobilized silicas for multi-phase extraction of aristolochic acid from plants and herbal medicines","volume":"1592","author":"Fang","year":"2019","journal-title":"J. Chromatogr. 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