{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:03:49Z","timestamp":1792109029366,"version":"4.4.0"},"reference-count":54,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T00:00:00Z","timestamp":1703203200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Princess Nourah bint Abdulrahman University","award":["PNURSP2023R141"],"award-info":[{"award-number":["PNURSP2023R141"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Cannabis is considered (Cannabis sativa L.) a sacred herb in many countries and is vastly employed in traditional medicine to remedy numerous diseases, such as diabetes. This research investigates the chemical composition of the aqueous extracts from Cannabis sativa L. seeds. Furthermore, the impact of these extracts on pancreatic \u03b1-amylase and lipase, and intestinal \u03b1-glucosidase enzymes is evaluated, as well as their antihyperglycemic effect. Analysis of the chemical composition of the aqueous extract was conducted using high-performance liquid chromatography with a photodiode array detector (HPLC-DAD). In contrast, the ethanol, hexanic, dichloromethane, and aqueous extract compositions have been established. Additionally, the inhibitory effects of ethanolic, dichloromethane, and aqueous extracts on pancreatic \u03b1-amylase and lipase, and intestinal \u03b1-glucosidase activities were evaluated in vitro and in vivo. The results of HPLC analysis indicate that the most abundant phenolic compound in the aqueous cannabis seed extract is 3-hydroxycinnamic acid, followed by 4-hydroxybenzoic acid and rutin acid. Moreover, administration of ethanolic and aqueous extracts at a dose of 150 mg\/Kg significantly suppressed postprandial hyperglycemia compared to the control group; the ethanolic, dichloromethane, and aqueous extracts significantly inhibit pancreatic \u03b1-amylase and lipase, and intestinal \u03b1-glucosidase in vitro. The pancreatic \u03b1-amylase test exhibited an inhibition with IC50 values of 16.36 \u00b1 1.24 \u00b5g\/mL, 19.33 \u00b1 1.40 \u00b5g\/mL, 23.53 \u00b1 1.70 \u00b5g\/mL, and 17.06 \u00b1 9.91 \u00b5g\/mL for EAq, EDm, EET, and EHx, respectively. EET has the highest inhibitory capacity for intestinal \u03b1-glucosidase activity, with an IC50 of 32.23 \u00b1 3.26 \u00b5g\/mL. The extracts inhibit porcine pancreatic lipase activity, demonstrating their potential as lipase inhibitors. Specifically, at a concentration of 1 mg\/mL, the highest inhibition rate (77%) was observed for EDm. To confirm these results, the inhibitory effect of these extracts on enzymes was tested in vivo. The oral intake of aqueous extract markedly reduced starch- and sucrose-induced hyperglycemia in healthy rats. Administration of the ethanolic extract at a specific dose of 150 mg\/kg significantly reduced postprandial glycemia compared with the control group. It is, therefore, undeniable that cannabis extracts represent a promising option as a potentially effective treatment for type 2 diabetes.<\/jats:p>","DOI":"10.3390\/molecules29010093","type":"journal-article","created":{"date-parts":[[2023,12,24]],"date-time":"2023-12-24T20:49:27Z","timestamp":1703450967000},"page":"93","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Chemical Analysis of the Antihyperglycemic, and Pancreatic \u03b1-Amylase, Lipase, and Intestinal \u03b1-Glucosidase Inhibitory Activities of Cannabis sativa L. Seed Extracts"],"prefix":"10.3390","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4862-5846","authenticated-orcid":false,"given":"Salima","family":"Haddou","sequence":"first","affiliation":[{"name":"Laboratory of Advanced Materials and Process Engineering, Faculty of Science, University Ibn Tofail, University Street, B.P. 242, Kenitra 14000, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amal","family":"Elrherabi","sequence":"additional","affiliation":[{"name":"Laboratory of Bioresources, Biotechnology, Ethnopharmacology and Health, Faculty of Sciences, University Mohammed 1st, Bd. Med VI B.P. 717, Oujda 60000, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5678-1905","authenticated-orcid":false,"given":"El Hassania","family":"Loukili","sequence":"additional","affiliation":[{"name":"Laboratory of Applied Chemistry & Environment, Faculty of Sciences, University Mohammed 1st, Bd. Med VI B.P. 717, Oujda 60000, Morocco"},{"name":"Euro-Mediterranean University of Fes (UEMF), B.P. 15, Fes 30070, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rhizlan","family":"Abdnim","sequence":"additional","affiliation":[{"name":"Laboratory of Bioresources, Biotechnology, Ethnopharmacology and Health, Faculty of Sciences, University Mohammed 1st, Bd. Med VI B.P. 717, Oujda 60000, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2367-146X","authenticated-orcid":false,"given":"Asmae","family":"Hbika","sequence":"additional","affiliation":[{"name":"Laboratory of Applied Chemistry & Environment, Faculty of Sciences, University Mohammed 1st, Bd. Med VI B.P. 717, Oujda 60000, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9944-811X","authenticated-orcid":false,"given":"Mohamed","family":"Bouhrim","sequence":"additional","affiliation":[{"name":"Laboratories TBC, Laboratory of Pharmacology, Pharmacokinetics and Clinical Pharmacy, Faculty of Pharmacy, University of Lille, 59000 Lille, France"},{"name":"Laboratory of Biological Engineering, Team of Functional and Pathological Biology, Faculty of Sciences and Technology, University Sultan Moulay Slimane, Beni Mellal 23000, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4706-4311","authenticated-orcid":false,"given":"Omkulthom","family":"Al Kamaly","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asmaa","family":"Saleh","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0456-3196","authenticated-orcid":false,"given":"Abdelaaty A.","family":"Shahat","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, College of Pharmacy King Saud University, Riyadh 11362, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9473-1290","authenticated-orcid":false,"given":"Mohamed","family":"Bnouham","sequence":"additional","affiliation":[{"name":"Laboratory of Bioresources, Biotechnology, Ethnopharmacology and Health, Faculty of Sciences, University Mohammed 1st, Bd. Med VI B.P. 717, Oujda 60000, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3673-7904","authenticated-orcid":false,"given":"Belkheir","family":"Hammouti","sequence":"additional","affiliation":[{"name":"Euro-Mediterranean University of Fes (UEMF), B.P. 15, Fes 30070, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5810-1088","authenticated-orcid":false,"given":"Abdelkrim","family":"Chahine","sequence":"additional","affiliation":[{"name":"Laboratory of Advanced Materials and Process Engineering, Faculty of Science, University Ibn Tofail, University Street, B.P. 242, Kenitra 14000, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1007\/s11746-006-5037-7","article-title":"Oxidative stability of flax and hemp oils","volume":"83","author":"Abuzaytoun","year":"2006","journal-title":"J. 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