{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T12:25:17Z","timestamp":1789129517201,"version":"build-2803163510"},"reference-count":139,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2023,12,28]],"date-time":"2023-12-28T00:00:00Z","timestamp":1703721600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Scientific Research Funds of Huaqiao University","award":["Z16Y0017"],"award-info":[{"award-number":["Z16Y0017"]}]},{"name":"Scientific Research Funds of Huaqiao University","award":["32271002"],"award-info":[{"award-number":["32271002"]}]},{"name":"National Natural Science Foundation of China","award":["Z16Y0017"],"award-info":[{"award-number":["Z16Y0017"]}]},{"name":"National Natural Science Foundation of China","award":["32271002"],"award-info":[{"award-number":["32271002"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Transient receptor potential vanilloid 1 (TRPV1) is a transmembrane and non-selective cation channel protein, which can be activated by various physical and chemical stimuli. Recent studies have shown the strong pathogenetic associations of TRPV1 with neurodegenerative diseases (NDs), in particular Alzheimer\u2019s disease (AD), Parkinson\u2019s disease (PD) and multiple sclerosis (MS) via regulating neuroinflammation. Therapeutic effects of TRPV1 agonists and antagonists on the treatment of AD and PD in animal models also are emerging. We here summarize the current understanding of TRPV1\u2019s effects and its agonists and antagonists as a therapeutic means in neurodegenerative diseases, and highlight future treatment strategies using natural TRPV1 agonists. Developing new targets and applying natural products are becoming a promising direction in the treatment of chronic disorders, especially neurodegenerative diseases.<\/jats:p>","DOI":"10.3390\/molecules29010181","type":"journal-article","created":{"date-parts":[[2023,12,28]],"date-time":"2023-12-28T09:35:21Z","timestamp":1703756121000},"page":"181","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Impact of TRPV1 on Pathogenesis and Therapy of Neurodegenerative Diseases"],"prefix":"10.3390","volume":"29","author":[{"given":"Wenxin","family":"Wang","sequence":"first","affiliation":[{"name":"Center for Precision Medicine, School of Medicine and School of Biomedical Sciences, Huaqiao University, Xiamen 361021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2969-2226","authenticated-orcid":false,"given":"Tao","family":"Sun","sequence":"additional","affiliation":[{"name":"Center for Precision Medicine, School of Medicine and School of Biomedical Sciences, Huaqiao University, Xiamen 361021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.cell.2022.12.032","article-title":"Hallmarks of neurodegenerative diseases","volume":"186","author":"Wilson","year":"2023","journal-title":"Cell"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Agnello, L., and Ciaccio, M. (2022). Neurodegenerative Diseases: From Molecular Basis to Therapy. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232112854"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"763866","DOI":"10.3389\/fphar.2021.763866","article-title":"TRPV1-Mediated Microglial Autophagy Attenuates Alzheimer\u2019s Disease-Associated Pathology and Cognitive Decline","volume":"12","author":"Wang","year":"2021","journal-title":"Front. Pharmacol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"e2108435","DOI":"10.1002\/adma.202108435","article-title":"Controlled Activation of TRPV1 Channels on Microglia to Boost Their Autophagy for Clearance of Alpha-Synuclein and Enhance Therapy of Parkinson\u2019s Disease","volume":"34","author":"Yuan","year":"2022","journal-title":"Adv. Mater."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2130","DOI":"10.1016\/j.pain.2013.06.040","article-title":"TRPV1 channels make major contributions to behavioral hypersensitivity and spontaneous activity in nociceptors after spinal cord injury","volume":"154","author":"Wu","year":"2013","journal-title":"Pain"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1089\/neu.2018.5942","article-title":"Inhibition of Transient Receptor Potential Vanilloid 1 Attenuates Blood-Brain Barrier Disruption after Traumatic Brain Injury in Mice","volume":"36","author":"Yang","year":"2019","journal-title":"J. Neurotrauma"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"30","DOI":"10.3389\/fneur.2019.00030","article-title":"Transient Receptor Potential Vanilloid 1 Modulates Central Inflammation in Multiple Sclerosis","volume":"10","author":"Gentile","year":"2019","journal-title":"Front. Neurol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.neuropharm.2014.05.034","article-title":"\u201cHotheaded\u201d: The role OF TRPV1 in brain functions","volume":"85","author":"Martins","year":"2014","journal-title":"Neuropharmacology"},{"key":"ref_9","first-page":"1568145","article-title":"Perspectives of TRPV1 Function on the Neurogenesis and Neural Plasticity","volume":"2016","author":"Cordova","year":"2016","journal-title":"Neural Plast."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.bbi.2017.03.007","article-title":"Modulation of neuroinflammation: Role and therapeutic potential of TRPV1 in the neuro-immune axis","volume":"64","author":"Kong","year":"2017","journal-title":"Brain Behav. Immun."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"10143","DOI":"10.1523\/JNEUROSCI.5779-12.2013","article-title":"TRPA1 channels are regulators of astrocyte basal calcium levels and long-term potentiation via constitutive D-serine release","volume":"33","author":"Shigetomi","year":"2013","journal-title":"J. Neurosci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"4322","DOI":"10.4049\/jimmunol.177.7.4322","article-title":"Transient receptor potential vanilloid subtype 1 mediates microglial cell death in vivo and in vitro via Ca2+-mediated mitochondrial damage and cytochrome c release","volume":"177","author":"Kim","year":"2006","journal-title":"J. Immunol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.brainresbull.2012.07.001","article-title":"Transient receptor potential vanilloid subtype 1 contributes to mesencephalic dopaminergic neuronal survival by inhibiting microglia-originated oxidative stress","volume":"89","author":"Park","year":"2012","journal-title":"Brain Res. Bull."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1016\/j.neuroscience.2006.02.074","article-title":"Immunohistochemical localization of cannabinoid type 1 and vanilloid transient receptor potential vanilloid type 1 receptors in the mouse brain","volume":"139","author":"Cristino","year":"2006","journal-title":"Neuroscience"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.jneuroim.2009.07.008","article-title":"Importance of the non-selective cation channel TRPV1 for microglial reactive oxygen species generation","volume":"216","author":"Schilling","year":"2009","journal-title":"J. Neuroimmunol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.bbi.2020.06.033","article-title":"Transient receptor potential V1 (TRPV1) modulates the therapeutic effects for comorbidity of pain and depression: The common molecular implication for electroacupuncture and omega-3 polyunsaturated fatty acids","volume":"89","author":"Lin","year":"2020","journal-title":"Brain Behav. Immun."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Zschenderlein, C., Gebhardt, C., von Bohlen Und Halbach, O., Kulisch, C., and Albrecht, D. (2011). Capsaicin-induced changes in LTP in the lateral amygdala are mediated by TRPV1. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0016116"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.expneurol.2007.07.021","article-title":"Anti-dyskinetic effects of cannabinoids in a rat model of Parkinson\u2019s disease: Role of CB(1) and TRPV1 receptors","volume":"208","author":"Morgese","year":"2007","journal-title":"Exp. Neurol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1177\/0269881119864943","article-title":"Transient receptor potential vanilloid 1 mediates cocaine reinstatement via the D1 dopamine receptor in the nucleus accumbens","volume":"33","author":"You","year":"2019","journal-title":"J. Psychopharmacol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.biopsych.2005.08.019","article-title":"Endocannabinoids activate transient receptor potential vanilloid 1 receptors to reduce hyperdopaminergia-related hyperactivity: Therapeutic implications","volume":"59","author":"Tzavara","year":"2006","journal-title":"Biol. Psychiatry"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.1093\/cercor\/bhr328","article-title":"TRPV1-dependent and -independent alterations in the limbic cortex of neuropathic mice: Impact on glial caspases and pain perception","volume":"22","author":"Giordano","year":"2012","journal-title":"Cereb. Cortex"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1152\/jn.00004.2018","article-title":"Interaction between TRPV1-expressing neurons in the hypothalamus","volume":"121","author":"Molinas","year":"2019","journal-title":"J. Neurophysiol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"100051","DOI":"10.1016\/j.labinv.2022.100051","article-title":"The Roles of Transient Receptor Potential Vanilloid 1 and 4 in Olfactory Regeneration","volume":"103","author":"Sakatani","year":"2023","journal-title":"Lab. Investig."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"726893","DOI":"10.3389\/fncir.2021.726893","article-title":"Midbrain Dopamine Neurons Defined by TrpV1 Modulate Psychomotor Behavior","volume":"15","author":"Serra","year":"2021","journal-title":"Front. Neural Circuits"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1097\/WNR.0b013e3283546242","article-title":"Alterations in microglia and astrocytes in the trigeminal nucleus caudalis by repetitive TRPV1 stimulation on the trigeminal nociceptors","volume":"23","author":"Kuroi","year":"2012","journal-title":"Neuroreport"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.expneurol.2009.09.030","article-title":"Influence of the vanilloid receptor TRPV1 on the activation of spinal cord glia in mouse models of pain","volume":"220","author":"Chen","year":"2009","journal-title":"Exp. Neurol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2426","DOI":"10.1111\/bph.12615","article-title":"Cannabidiol enhances microglial phagocytosis via transient receptor potential (TRP) channel activation","volume":"171","author":"Hassan","year":"2014","journal-title":"Br. J. Pharmacol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"3004","DOI":"10.1167\/iovs.07-1355","article-title":"Contribution of TRPV1 to microglia-derived IL-6 and NFkappaB translocation with elevated hydrostatic pressure","volume":"49","author":"Sappington","year":"2008","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.neuroscience.2012.11.015","article-title":"P2X3 and TRPV1 functionally interact and mediate sensitization of trigeminal sensory neurons","volume":"232","author":"Saloman","year":"2013","journal-title":"Neuroscience"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Bagood, M.D., and Isseroff, R.R. (2021). TRPV1: Role in Skin and Skin Diseases and Potential Target for Improving Wound Healing. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22116135"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Storozhuk, M.V., Moroz, O.F., and Zholos, A.V. (2019). Multifunctional TRPV1 Ion Channels in Physiology and Pathology with Focus on the Brain, Vasculature, and Some Visceral Systems. Biomed. Res. Int., 2019.","DOI":"10.1155\/2019\/5806321"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.7150\/ijbs.59918","article-title":"The Impact of TRPV1 on Cancer Pathogenesis and Therapy: A Systematic Review","volume":"17","author":"Li","year":"2021","journal-title":"Int. J. Biol. Sci."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/nature12823","article-title":"TRPV1 structures in distinct conformations reveal activation mechanisms","volume":"504","author":"Cao","year":"2013","journal-title":"Nature"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1038\/39807","article-title":"The capsaicin receptor: A heat-activated ion channel in the pain pathway","volume":"389","author":"Caterina","year":"1997","journal-title":"Nature"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/nature12822","article-title":"Structure of the TRPV1 ion channel determined by electron cryo-microscopy","volume":"504","author":"Liao","year":"2013","journal-title":"Nature"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Ben\u00edtez-Angeles, M., Morales-L\u00e1zaro, S.L., Ju\u00e1rez-Gonz\u00e1lez, E., and Rosenbaum, T. (2020). TRPV1: Structure, Endogenous Agonists, and Mechanisms. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21103421"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s00424-005-1457-8","article-title":"Structure and function of TRPV1","volume":"451","author":"Tominaga","year":"2005","journal-title":"Pflug. Arch."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/S0896-6273(00)80564-4","article-title":"The cloned capsaicin receptor integrates multiple pain-producing stimuli","volume":"21","author":"Tominaga","year":"1998","journal-title":"Neuron"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1523\/JNEUROSCI.23-04-01340.2003","article-title":"Functional role of C-terminal cytoplasmic tail of rat vanilloid receptor 1","volume":"23","author":"Teisinger","year":"2003","journal-title":"J. Neurosci."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Uchytilova, E., Spicarova, D., and Palecek, J. (2021). Hypersensitivity Induced by Intrathecal Bradykinin Administration Is Enhanced by N-oleoyldopamine (OLDA) and Prevented by TRPV1 Antagonist. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22073712"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/22761","article-title":"Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide","volume":"400","author":"Zygmunt","year":"1999","journal-title":"Nature"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"8400","DOI":"10.1073\/pnas.122196999","article-title":"An endogenous capsaicin-like substance with high potency at recombinant and native vanilloid VR1 receptors","volume":"99","author":"Huang","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s13238-016-0353-7","article-title":"Understand spiciness: Mechanism of TRPV1 channel activation by capsaicin","volume":"8","author":"Yang","year":"2017","journal-title":"Protein Cell"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Liu, M., Jia, X., Liu, H., He, R., Zhang, X., and Shao, Y. (2022). Role of TRPV1 in respiratory disease and association with traditional Chinese medicine: A literature review. Biomed. Pharmacother., 155.","DOI":"10.1016\/j.biopha.2022.113676"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Ju\u00e1rez-Contreras, R., M\u00e9ndez-Res\u00e9ndiz, K.A., Rosenbaum, T., Gonz\u00e1lez-Ram\u00edrez, R., and Morales-L\u00e1zaro, S.L. (2020). TRPV1 Channel: A Noxious Signal Transducer That Affects Mitochondrial Function. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21238882"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Munjuluri, S., Wilkerson, D.A., Sooch, G., Chen, X., White, F.A., and Obukhov, A.G. (2021). Capsaicin and TRPV1 Channels in the Cardiovascular System: The Role of Inflammation. Cells, 11.","DOI":"10.3390\/cells11010018"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"e153558","DOI":"10.1172\/JCI153558","article-title":"Nociception and pain in humans lacking a functional TRPV1 channel","volume":"133","author":"Katz","year":"2023","journal-title":"J. Clin. Investig."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1038\/emboj.2010.325","article-title":"TRPV1-lineage neurons are required for thermal sensation","volume":"30","author":"Mishra","year":"2011","journal-title":"EMBO J."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"4170","DOI":"10.1016\/j.cell.2022.09.008","article-title":"Gut-innervating nociceptors regulate the intestinal microbiota to promote tissue protection","volume":"185","author":"Zhang","year":"2022","journal-title":"Cell"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"108712","DOI":"10.1016\/j.neuropharm.2021.108712","article-title":"Cannabidiol effectively reverses mechanical and thermal allodynia, hyperalgesia, and anxious behaviors in a neuropathic pain model: Possible role of CB1 and TRPV1 receptors","volume":"197","author":"Hallak","year":"2021","journal-title":"Neuropharmacology"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.biopsych.2008.02.020","article-title":"Antistress effect of TRPV1 channel on synaptic plasticity and spatial memory","volume":"64","author":"Li","year":"2008","journal-title":"Biol. Psychiatry"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"517","DOI":"10.3390\/cells3020517","article-title":"TRPV1: A Potential Drug Target for Treating Various Diseases","volume":"3","author":"Brito","year":"2014","journal-title":"Cells"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s40035-020-00221-2","article-title":"Neuroinflammation in neurodegenerative disorders: The roles of microglia and astrocytes","volume":"9","author":"Kwon","year":"2020","journal-title":"Transl. Neurodegener."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.nbd.2011.05.018","article-title":"Transient receptor potential vanilloid 1 channels modulate the synaptic effects of TNF-\u03b1 and of IL-1\u03b2 in experimental autoimmune encephalomyelitis","volume":"43","author":"Musumeci","year":"2011","journal-title":"Neurobiol. Dis."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1038\/s41419-021-04450-9","article-title":"TRPV1 channel mediates NLRP3 inflammasome-dependent neuroinflammation in microglia","volume":"12","author":"Zhang","year":"2021","journal-title":"Cell Death Dis."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.pbb.2014.03.022","article-title":"Pharmacological benefits of agomelatine and vanillin in experimental model of Huntington\u2019s disease","volume":"122","author":"Gupta","year":"2014","journal-title":"Pharmacol. Biochem. Behav."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"2803","DOI":"10.1093\/brain\/awaa223","article-title":"Phosphorylated tau interactome in the human Alzheimer\u2019s disease brain","volume":"143","author":"Drummond","year":"2020","journal-title":"Brain"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s13024-019-0333-5","article-title":"The neuropathological diagnosis of Alzheimer\u2019s disease","volume":"14","author":"DeTure","year":"2019","journal-title":"Mol. Neurodegener."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1038\/nrgastro.2013.76","article-title":"Gut microbiota: Intestinal bacteria influence brain activity in healthy humans","volume":"10","author":"Collins","year":"2013","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S0140-6736(20)30367-6","article-title":"Dementia prevention, intervention, and care: 2020 report of the Lancet Commission","volume":"396","author":"Livingston","year":"2020","journal-title":"Lancet"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.nbd.2005.09.004","article-title":"Alzheimer\u2019s disease: mRNA expression profiles of multiple patients show alterations of genes involved with calcium signaling","volume":"21","author":"Emilsson","year":"2006","journal-title":"Neurobiol. Dis."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1093\/hmg\/ddz276","article-title":"Ca2+-permeable TRPV1 pain receptor knockout rescues memory deficits and reduces amyloid-\u03b2 and tau in a mouse model of Alzheimer\u2019s disease","volume":"29","author":"Kim","year":"2020","journal-title":"Hum. Mol. Genet."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1093\/brain\/awab281","article-title":"Astrocyte-neuron interplay is critical for Alzheimer\u2019s disease pathogenesis and is rescued by TRPA1 channel blockade","volume":"145","author":"Paumier","year":"2022","journal-title":"Brain"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/s12276-023-00935-z","article-title":"TRPV1 regulates ApoE4-disrupted intracellular lipid homeostasis and decreases synaptic phagocytosis by microglia","volume":"55","author":"Wang","year":"2023","journal-title":"Exp. Mol. Med."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"8740","DOI":"10.1073\/pnas.1206171109","article-title":"Critical role of soluble amyloid-\u03b2 for early hippocampal hyperactivity in a mouse model of Alzheimer\u2019s disease","volume":"109","author":"Busche","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1126\/science.aay0198","article-title":"A vicious cycle of \u03b2 amyloid-dependent neuronal hyperactivation","volume":"365","author":"Zott","year":"2019","journal-title":"Science"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1002\/bies.201500004","article-title":"Neuronal hyperactivity\u2014A key defect in Alzheimer\u2019s disease?","volume":"37","author":"Busche","year":"2015","journal-title":"Bioessays"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/s41593-018-0080-x","article-title":"Imbalance between firing homeostasis and synaptic plasticity drives early-phase Alzheimer\u2019s disease","volume":"21","author":"Styr","year":"2018","journal-title":"Nat. Neurosci."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/nature20587","article-title":"Gamma frequency entrainment attenuates amyloid load and modifies microglia","volume":"540","author":"Iaccarino","year":"2016","journal-title":"Nature"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"11416","DOI":"10.1523\/JNEUROSCI.1195-14.2014","article-title":"Amyloid-\u03b2-induced action potential desynchronization and degradation of hippocampal gamma oscillations is prevented by interference with peptide conformation change and aggregation","volume":"34","author":"Kurudenkandy","year":"2014","journal-title":"J. Neurosci."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"e37703","DOI":"10.7554\/eLife.37703","article-title":"TrpV1 receptor activation rescues neuronal function and network gamma oscillations from A\u03b2-induced impairment in mouse hippocampus in vitro","volume":"7","author":"Crux","year":"2018","journal-title":"eLife"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.pharmthera.2009.10.005","article-title":"The paradoxical role of the transient receptor potential vanilloid 1 receptor in inflammation","volume":"125","author":"Alawi","year":"2010","journal-title":"Pharmacol. Ther."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.1016\/S0140-6736(21)00218-X","article-title":"Parkinson\u2019s disease","volume":"397","author":"Bloem","year":"2021","journal-title":"Lancet"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S1474-4422(21)00030-2","article-title":"Challenges in the diagnosis of Parkinson\u2019s disease","volume":"20","author":"Tolosa","year":"2021","journal-title":"Lancet Neurol."},{"key":"ref_75","first-page":"45","article-title":"Preventing Parkinson\u2019s Disease: An Environmental Agenda","volume":"12","author":"Goldman","year":"2022","journal-title":"J. Park. Dis."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.pharmthera.2011.11.006","article-title":"Voltage-gated calcium channels and Parkinson\u2019s disease","volume":"133","author":"Hurley","year":"2012","journal-title":"Pharmacol. Ther."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"5094","DOI":"10.1038\/s41467-019-12834-x","article-title":"Cav2.3 channels contribute to dopaminergic neuron loss in a model of Parkinson\u2019s disease","volume":"10","author":"Benkert","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Vaidya, B., and Sharma, S.S. (2020). Transient Receptor Potential Channels as an Emerging Target for the Treatment of Parkinson\u2019s Disease: An Insight into Role of Pharmacological Interventions. Front. Cell Dev. Biol., 8.","DOI":"10.3389\/fcell.2020.584513"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1111\/fcp.12015","article-title":"Pharmacological blockade of TRPV1 receptors modulates the effects of 6-OHDA on motor and cognitive functions in a rat model of Parkinson\u2019s disease","volume":"27","author":"Razavinasab","year":"2013","journal-title":"Fundam. Clin. Pharmacol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.nbd.2016.06.013","article-title":"Co-administration of cannabidiol and capsazepine reduces L-DOPA-induced dyskinesia in mice: Possible mechanism of action","volume":"94","year":"2016","journal-title":"Neurobiol. Dis."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"S47","DOI":"10.1212\/WNL.62.1_suppl_1.S47","article-title":"Avoidance of dyskinesia: Preclinical evidence for continuous dopaminergic stimulation","volume":"62","author":"Jenner","year":"2004","journal-title":"Neurology"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.nbd.2013.10.008","article-title":"Oleoylethanolamide reduces L-DOPA-induced dyskinesia via TRPV1 receptor in a mouse model of Parkinson\u2019s disease","volume":"62","author":"Moratalla","year":"2014","journal-title":"Neurobiol. Dis."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"e298","DOI":"10.1038\/emm.2016.159","article-title":"Capsaicin prevents degeneration of dopamine neurons by inhibiting glial activation and oxidative stress in the MPTP model of Parkinson\u2019s disease","volume":"49","author":"Chung","year":"2017","journal-title":"Exp. Mol. Med."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"3610","DOI":"10.1093\/brain\/awv297","article-title":"TRPV1 on astrocytes rescues nigral dopamine neurons in Parkinson\u2019s disease via CNTF","volume":"138","author":"Nam","year":"2015","journal-title":"Brain"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.plipres.2016.02.002","article-title":"Endocannabinoids and endocannabinoid-related mediators: Targets, metabolism and role in neurological disorders","volume":"62","author":"Iannotti","year":"2016","journal-title":"Prog. Lipid Res."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/ni.3389","article-title":"T cell-intrinsic ASC critically promotes T(H)17-mediated experimental autoimmune encephalomyelitis","volume":"17","author":"Martin","year":"2016","journal-title":"Nat. Immunol."},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Landolfo, E., Cutuli, D., Petrosini, L., and Caltagirone, C. (2022). Effects of Palmitoylethanolamide on Neurodegenerative Diseases: A Review from Rodents to Humans. Biomolecules, 12.","DOI":"10.3390\/biom12050667"},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Payrits, M., Horv\u00e1th, \u00c1., Bir\u00f3-S\u00fct\u0151, T., Erosty\u00e1k, J., Makkai, G., S\u00e1ghy, \u00c9., Poh\u00f3czky, K., Kecsk\u00e9s, A., Kecsk\u00e9s, M., and Szolcs\u00e1nyi, J. (2020). Resolvin D1 and D2 Inhibit Transient Receptor Potential Vanilloid 1 and Ankyrin 1 Ion Channel Activation on Sensory Neurons via Lipid Raft Modification. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21145019"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.neuro.2020.11.010","article-title":"Neuroprotective and neurotoxic effects of endocannabinoid-like compounds, N-arachidonoyl dopamine and N-docosahexaenoyl dopamine in differentiated cultures of induced pluripotent stem cells derived from patients with Parkinson\u2019s disease","volume":"82","author":"Novosadova","year":"2021","journal-title":"Neurotoxicology"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"2341","DOI":"10.4049\/jimmunol.172.4.2341","article-title":"Immunosuppressive activity of endovanilloids: N-arachidonoyl-dopamine inhibits activation of the NF-kappa B, NFAT, and activator protein 1 signaling pathways","volume":"172","author":"Sancho","year":"2004","journal-title":"J. Immunol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.neuropharm.2017.04.011","article-title":"N-oleoyldopamine modulates activity of midbrain dopaminergic neurons through multiple mechanisms","volume":"119","author":"Sergeeva","year":"2017","journal-title":"Neuropharmacology"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"503","DOI":"10.3233\/JAD-131223","article-title":"Modulation of amyloid-\u03b2 production by leukotriene B4 via the \u03b3-secretase pathway","volume":"38","author":"Joshi","year":"2014","journal-title":"J. Alzheimers Dis."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s13024-023-00648-x","article-title":"Oleoylethanolamide facilitates PPARa and TFEB signaling and attenuates Ab pathology in a mouse model of Alzheimer\u2019s disease","volume":"18","author":"Comerota","year":"2023","journal-title":"Mol. Neurodegener."},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Pasierski, M., and Szulczyk, B. (2022). Beneficial Effects of Capsaicin in Disorders of the Central Nervous System. Molecules, 27.","DOI":"10.3390\/molecules27082484"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"653","DOI":"10.3389\/fnins.2018.00653","article-title":"Anandamide Effects in a Streptozotocin-Induced Alzheimer\u2019s Disease-Like Sporadic Dementia in Rats","volume":"12","author":"Carrettiero","year":"2018","journal-title":"Front. Neurosci."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.jnutbio.2019.05.009","article-title":"Piperine attenuates cognitive impairment in an experimental mouse model of sporadic Alzheimer\u2019s disease","volume":"70","author":"Wang","year":"2019","journal-title":"J. Nutr. Biochem."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1080\/15548627.2021.1937897","article-title":"Piperine promotes autophagy flux by P2RX4 activation in SNCA\/\u03b1-synuclein-induced Parkinson disease model","volume":"18","author":"Li","year":"2022","journal-title":"Autophagy"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.bbrc.2019.06.039","article-title":"A distinct structural mechanism underlies TRPV1 activation by piperine","volume":"516","author":"Dong","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"809621","DOI":"10.3389\/fnut.2022.809621","article-title":"Potential Role of Ginger (Zingiber officinale Roscoe) in the Prevention of Neurodegenerative Diseases","volume":"9","author":"Arcusa","year":"2022","journal-title":"Front. Nutr."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/s11571-017-9471-z","article-title":"Protective effects of evodiamine in experimental paradigm of Alzheimer\u2019s disease","volume":"12","author":"Wang","year":"2018","journal-title":"Cogn. Neurodyn."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"8958","DOI":"10.3390\/ijms13078958","article-title":"Binding mode pediction of evodiamine within vanilloid receptor TRPV1","volume":"13","author":"Wang","year":"2012","journal-title":"Int. J. Mol. Sci."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41582-019-0284-z","article-title":"Cannabinoids and the expanded endocannabinoid system in neurological disorders","volume":"16","author":"Cristino","year":"2020","journal-title":"Nat. Rev. Neurol."},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Tedeschi, P., Nigro, M., Travagli, A., Catani, M., Cavazzini, A., Merighi, S., and Gessi, S. (2022). Therapeutic Potential of Allicin and Aged Garlic Extract in Alzheimer\u2019s Disease. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23136950"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/nn2056","article-title":"A single N-terminal cysteine in TRPV1 determines activation by pungent compounds from onion and garlic","volume":"11","author":"Salazar","year":"2008","journal-title":"Nat. Neurosci."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.brainres.2005.05.024","article-title":"Arvanil, a hybrid endocannabinoid and vanilloid compound, behaves as an antihyperkinetic agent in a rat model of Huntington\u2019s disease","volume":"1050","author":"Urbani","year":"2005","journal-title":"Brain Res."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.bbrc.2015.03.109","article-title":"Resolvin D2 recovers neural injury by suppressing inflammatory mediators expression in lipopolysaccharide-induced Parkinson\u2019s disease rat model","volume":"460","author":"Tian","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.pharep.2018.08.004","article-title":"Caffeic acid improves locomotor activity and lessens inflammatory burden in a mouse model of rotenone-induced nigral neurodegeneration: Relevance to Parkinson\u2019s disease therapy","volume":"71","author":"Zaitone","year":"2019","journal-title":"Pharmacol. Rep."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"667","DOI":"10.2174\/1389557516666161130100947","article-title":"Protective Effects of Caffeic Acid and the Alzheimer\u2019s Brain: An Update","volume":"17","author":"Habtemariam","year":"2017","journal-title":"Mini Rev. Med. Chem."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"3295","DOI":"10.1002\/jcp.22675","article-title":"Amyloid-\u03b2-induced reactive oxygen species production and priming are differentially regulated by ion channels in microglia","volume":"226","author":"Schilling","year":"2011","journal-title":"J. Cell Physiol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.neulet.2005.05.015","article-title":"Effects of the novel TRPV1 receptor antagonist SB366791 in vitro and in vivo in the rat","volume":"385","author":"Varga","year":"2005","journal-title":"Neurosci. Lett."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"2451","DOI":"10.1038\/s41467-023-38162-9","article-title":"Human TRPV1 structure and inhibition by the analgesic SB-366791","volume":"14","author":"Neuberger","year":"2023","journal-title":"Nat. Commun."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1124\/jpet.104.079855","article-title":"AMG 9810 [(E)-3-(4-t-butylphenyl)-N-(2,3-dihydrobenzo[b][1,4] dioxin-6-yl)acrylamide], a novel vanilloid receptor 1 (TRPV1) antagonist with antihyperalgesic properties","volume":"313","author":"Gavva","year":"2005","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.mito.2023.02.003","article-title":"2-Aminoethoxydiphenyl borate ameliorates mitochondrial dysfunctions in MPTP\/MPP(+) model of Parkinson\u2019s disease","volume":"69","author":"Vaidya","year":"2023","journal-title":"Mitochondrion"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"165","DOI":"10.4149\/gpb_2022016","article-title":"Transient receptor potential vanilloid (TRPV) channels: Basal properties and physiological potential","volume":"41","author":"Sasase","year":"2022","journal-title":"Gen. Physiol. Biophys."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"5322","DOI":"10.1080\/10408398.2021.1884840","article-title":"Extraction, purification, bioactivity and pharmacological effects of capsaicin: A review","volume":"62","author":"Wang","year":"2022","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s12937-023-00857-6","article-title":"Effects of spicy food consumption on overweight\/obesity, hypertension and blood lipids in China: A meta-analysis of cross-sectional studies","volume":"22","author":"Wang","year":"2023","journal-title":"Nutr. J."},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Yang, X., Tang, W., Mao, D., Liu, X., Qian, W., Dai, Y., Chen, L., and Ding, X. (2022). Spicy food consumption is associated with abdominal obesity among Chinese Han population aged 30\u201379 years in the Sichuan Basin: A population-based cross-sectional study. BMC Public Health, 22.","DOI":"10.1186\/s12889-022-14293-4"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"h3942","DOI":"10.1136\/bmj.h3942","article-title":"Consumption of spicy foods and total and cause specific mortality: Population based cohort study","volume":"351","author":"Lv","year":"2015","journal-title":"BMJ"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1080\/1040-830491379236","article-title":"Capsaicin and gastric ulcers","volume":"46","author":"Satyanarayana","year":"2006","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1124\/pr.112.006163","article-title":"Unravelling the mystery of capsaicin: A tool to understand and treat pain","volume":"64","author":"Brock","year":"2012","journal-title":"Pharmacol. Rev."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"e52013","DOI":"10.15252\/embr.202052013","article-title":"TRPV1 sustains microglial metabolic reprogramming in Alzheimer\u2019s disease","volume":"22","author":"Lu","year":"2021","journal-title":"EMBO Rep."},{"key":"ref_122","doi-asserted-by":"crossref","unstructured":"Baek, J.Y., Jeong, J.Y., Kim, K.I., Won, S.Y., Chung, Y.C., Nam, J.H., Cho, E.J., Ahn, T.B., Bok, E., and Shin, W.H. (2018). Inhibition of Microglia-Derived Oxidative Stress by Ciliary Neurotrophic Factor Protects Dopamine Neurons In Vivo from MPP+ Neurotoxicity. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19113543"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/s41398-020-00918-y","article-title":"Capsaicin consumption reduces brain amyloid-beta generation and attenuates Alzheimer\u2019s disease-type pathology and cognitive deficits in APP\/PS1 mice","volume":"10","author":"Wang","year":"2020","journal-title":"Transl. Psychiatry"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"683","DOI":"10.3233\/JAD-170337","article-title":"Capsaicin Attenuates Amyloid-\u03b2-Induced Synapse Loss and Cognitive Impairments in Mice","volume":"59","author":"Chen","year":"2017","journal-title":"J. Alzheimers Dis."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"e13113","DOI":"10.1111\/acel.13113","article-title":"TRPV1 activation alleviates cognitive and synaptic plasticity impairments through inhibiting AMPAR endocytosis in APP23\/PS45 mouse model of Alzheimer\u2019s disease","volume":"19","author":"Du","year":"2020","journal-title":"Aging Cell"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.3233\/JAD-151079","article-title":"The Associations between a Capsaicin-Rich Diet and Blood Amyloid-\u03b2 Levels and Cognitive Function","volume":"52","author":"Liu","year":"2016","journal-title":"J. Alzheimers Dis."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s12276-018-0111-4","article-title":"Modulation of M1\/M2 polarization by capsaicin contributes to the survival of dopaminergic neurons in the lipopolysaccharide-lesioned substantia nigra in vivo","volume":"50","author":"Bok","year":"2018","journal-title":"Exp. Mol. Med."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"289","DOI":"10.5607\/en.2019.28.2.289","article-title":"Delayed Treatment of Capsaicin Produces Partial Motor Recovery by Enhancing Dopamine Function in MPP(+)-lesioned Rats via Ciliary Neurotrophic Factor","volume":"28","author":"Kim","year":"2019","journal-title":"Exp. Neurobiol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"3296","DOI":"10.1007\/s11064-023-03983-z","article-title":"Capsaicin, The Vanilloid Receptor TRPV1 Agonist in Neuroprotection: Mechanisms Involved and Significance","volume":"48","year":"2023","journal-title":"Neurochem. Res."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.neuropharm.2018.09.006","article-title":"Mechanisms of N-oleoyldopamine activation of central histaminergic neurons","volume":"143","author":"Mazur","year":"2018","journal-title":"Neuropharmacology"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"9585","DOI":"10.1038\/s41598-018-27872-6","article-title":"N-Acyldopamine induces aggresome formation without proteasome inhibition and enhances protein aggregation via p62\/SQSTM1 expression","volume":"8","author":"Matsumoto","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1046\/j.1365-2990.2002.00394.x","article-title":"Early accumulation of p62 in neurofibrillary tanglesin Alzheimer\u2019s disease: Possible role in tangle formation","volume":"28","author":"Kuusisto","year":"2002","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"878303","DOI":"10.3389\/fnagi.2022.878303","article-title":"Autophagy Impairment in App Knock-in Alzheimer\u2019s Model Mice","volume":"14","author":"Jiang","year":"2022","journal-title":"Front. Aging Neurosci."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1126\/science.1169096","article-title":"Synchronous hyperactivity and intercellular calcium waves in astrocytes in Alzheimer mice","volume":"323","author":"Kuchibhotla","year":"2009","journal-title":"Science"},{"key":"ref_135","doi-asserted-by":"crossref","unstructured":"Barr\u00f3n-Gonz\u00e1lez, M., Montes-Aparicio, A.V., Cuevas-Galindo, M.E., Orozco-Su\u00e1rez, S., Barrientos, R., Alatorre, A., Querejeta, E., Trujillo-Ferrara, J.G., Farf\u00e1n-Garc\u00eda, E.D., and Soriano-Urs\u00faa, M.A. (2023). Boron-containing compounds on neurons: Actions and potential applications for treating neurodegenerative diseases. J. Inorg. Biochem., 238.","DOI":"10.1016\/j.jinorgbio.2022.112027"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1007\/s10571-020-01012-z","article-title":"Neuroprotective Effect of 2-Aminoethoxydiphenyl Borate (2-APB) in Amyloid \u03b2-Induced Memory Dysfunction: A Mechanistic Study","volume":"42","author":"Thapak","year":"2022","journal-title":"Cell Mol. Neurobiol."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1093\/bja\/aeq067","article-title":"Pharmacology of capsaicin-, anandamide-, and N-arachidonoyl-dopamine-evoked cell death in a homogeneous transient receptor potential vanilloid subtype 1 receptor population","volume":"104","author":"Davies","year":"2010","journal-title":"Br. J. Anaesth."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.ejphar.2013.07.041","article-title":"Piperine exerts anti-seizure effects via the TRPV1 receptor in mice","volume":"714","author":"Chen","year":"2013","journal-title":"Eur. J. Pharmacol."},{"key":"ref_139","first-page":"1","article-title":"Preparation, pungency and bioactivity of gingerols from ginger (Zingiber officinale Roscoe): A review","volume":"22","author":"Gao","year":"2022","journal-title":"Crit. Rev. Food Sci. Nutr."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/29\/1\/181\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:43:27Z","timestamp":1760132607000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/29\/1\/181"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,28]]},"references-count":139,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,1]]}},"alternative-id":["molecules29010181"],"URL":"https:\/\/doi.org\/10.3390\/molecules29010181","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,28]]}}}