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Borax is a traditional Chinese medicine with anti-corrosion, anti-inflammatory, antibacterial, and anticonvulsant effects. It is made by boiling, removing stones, and drying borax minerals like borate salts. This article introduces an 11B nuclear magnetic resonance method for identifying and characterizing boron-containing compounds in TCM. We applied this technology to borax aqueous solutions in different chemical environments and found that with boron mixed in the form of SP2 hybridization in equilateral triangles and SP3 hybridization in equilateral tetrahedra, the pH changes in alkaline environments significantly affected the ratio of the two. At the same time, it was found that in addition to the raw material peak, boron signals of other boron-containing compounds were also detected in 20 commercially available boron-containing TCM preparations. These new boron-containing compounds may be true pharmaceutical active ingredients, and adding them directly to the formula can improve quality and safety. This article describes the detection of 11B NMR in boron-containing traditional Chinese medicine preparations. It is simple, non-destructive, and can provide chemical fingerprint studies for boron-containing traditional Chinese medicine.<\/jats:p>","DOI":"10.3390\/molecules29010251","type":"journal-article","created":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T03:18:07Z","timestamp":1704251887000},"page":"251","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["11B NMR of the Morphological Evolution of Traditional Chinese Medicine Borax"],"prefix":"10.3390","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2926-4566","authenticated-orcid":false,"given":"Qiulin","family":"Li","sequence":"first","affiliation":[{"name":"Department of Chemistry and Chemical Engineering, Xi\u2019an University of Science & Technology, Xi\u2019an 710054, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yawen","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Chemical Engineering, Xi\u2019an University of Science & Technology, Xi\u2019an 710054, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingfeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Chemical Engineering, Xi\u2019an University of Science & Technology, Xi\u2019an 710054, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Chemical Engineering, Xi\u2019an University of Science & Technology, Xi\u2019an 710054, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5262-9092","authenticated-orcid":false,"given":"Junfeng","family":"Zhu","sequence":"additional","affiliation":[{"name":"School of Food and Biological Engineering, Shaanxi University of Science & Technology, Xi\u2019an 710021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Chemical Engineering, Xi\u2019an University of Science & Technology, Xi\u2019an 710054, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuhong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Safety Science and Engineering, Xi\u2019an University of Science & Technology, Xi\u2019an 710054, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanshe","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Chemical Engineering, Xi\u2019an University of Science & Technology, Xi\u2019an 710054, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pin","family":"Gong","sequence":"additional","affiliation":[{"name":"School of Food and Biological Engineering, Shaanxi University of Science & Technology, Xi\u2019an 710021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5384-7825","authenticated-orcid":false,"given":"Fuxin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Chemical Engineering, Xi\u2019an University of Science & Technology, Xi\u2019an 710054, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,1,3]]},"reference":[{"key":"ref_1","first-page":"87","article-title":"Research progress in traditional Chinese medicine borax","volume":"28","author":"Zhai","year":"2007","journal-title":"Prog. 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