{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:13:39Z","timestamp":1792790019186,"version":"4.5.0"},"reference-count":38,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2024,1,6]],"date-time":"2024-01-06T00:00:00Z","timestamp":1704499200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Korea Institute of Marine Science &amp; Technology Promotion (KIMST)","award":["KIMST-20220526"],"award-info":[{"award-number":["KIMST-20220526"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Suaeda glauca, a halophyte in the Amaranthaceae family, exhibits remarkable resilience to high salt and alkali stresses despite the absence of salt glands or vesicles in its leaves. While there is growing pharmacological interest in S. glauca, research on its secondary metabolites remains limited. In this study, chemical constituents of the aerial parts of S. glauca were identified using 1D- and 2D-NMR experiments, and its biological activity concerning hair loss was newly reported. Eight compounds, including alkaloids (1~3), flavonoids (4~6), and phenolics (7 and 8), were isolated. The compounds, except the flavonoids, were isolated for the first time from S. glauca. In the HPLC chromatogram, quercetin-3-O-\u03b2-d-glucoside, kaempferol-3-O-\u03b2-d-glucoside, and kaempferol were identified as major constituents in the extract of S. glauca. Additionally, the therapeutic potential of the extract of S. glauca and the isolated compounds 1~8 on the expressions of VEGF and IGF-1, as well as the regulation of Wnt\/\u03b2-catenin signaling, were evaluated in human follicle dermal papilla cells (HFDPCs) and human umbilical vein endothelial cells (HUVECs). Among the eight compounds, compound 4 was the most potent in terms of increasing the expression of VEGF and IGF-1 and the regulation of Wnt\/\u03b2-catenin. These findings suggest that S. glauca extract and its compounds are potential new candidates for preventing or treating hair loss.<\/jats:p>","DOI":"10.3390\/molecules29020298","type":"journal-article","created":{"date-parts":[[2024,1,8]],"date-time":"2024-01-08T05:21:38Z","timestamp":1704691298000},"page":"298","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Chemical Constituents of Halophyte Suaeda glauca and Their Therapeutic Potential for Hair Loss"],"prefix":"10.3390","volume":"29","author":[{"given":"Yun-Na","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Oceanography, Kunsan National University, Gunsan 54150, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min-Gyu","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Green Bio Science, Gyeongsang National University, Jinju 52725, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Jung","family":"Kim","sequence":"additional","affiliation":[{"name":"Agri-Food Bio Convergence Institute, Gyeongsang National University, Jinju 52725, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae-Sun","family":"Lee","sequence":"additional","affiliation":[{"name":"Agri-Food Bio Convergence Institute, Gyeongsang National University, Jinju 52725, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bong-Oh","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Oceanography, Kunsan National University, Gunsan 54150, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6443-632X","authenticated-orcid":false,"given":"Jung-Rae","family":"Rho","sequence":"additional","affiliation":[{"name":"Department of Oceanography, Kunsan National University, Gunsan 54150, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun-Ju","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Green Bio Science, Gyeongsang National University, Jinju 52725, Republic of Korea"},{"name":"Agri-Food Bio Convergence Institute, Gyeongsang National University, Jinju 52725, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,1,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1007\/s12272-001-1198-1","article-title":"In vitro hepatoprotective compounds from Suaeda glauca","volume":"31","author":"An","year":"2008","journal-title":"Arch. 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