{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T17:49:09Z","timestamp":1792432149624,"version":"4.5.0"},"reference-count":71,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T00:00:00Z","timestamp":1704844800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007076","name":"Fondazione AIRC per la Ricerca sul Cancro","doi-asserted-by":"publisher","award":["IG23566"],"award-info":[{"award-number":["IG23566"]}],"id":[{"id":"10.13039\/501100007076","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>A new class of palladium\u2013indenyl complexes characterized by the presence of one bulky alkyl isocyanide and one aryl phosphine serving as ancillary ligands has been prepared, presenting high yields and selectivity. All the new products were completely characterized using spectroscopic and spectrometric techniques (NMR, FT-IR, and HRMS), and, for most of them, it was also possible to define their solid-state structures via X-ray diffractometry, revealing that the indenyl fragment always binds to the metal centre with a hapticity intermediate between \u019e3 and \u019e5. A reactivity study carried out using piperidine as a nucleophilic agent proved that the indenyl moiety is the eligible site of attack rather than the isocyanide ligand or the metal centre. All complexes were tested as potential anticancer agents against three ovarian cancer cell lines (A2780, A2780cis, and OVCAR-5) and one breast cancer cell line (MDA-MB-231), displaying comparable activity with respect to cisplatin, which was used as a positive control. Moreover, the similar cytotoxicity observed towards A2780 and A2780cis cells (cisplatin-sensitive and cisplatin-resistant, respectively) suggests that our palladium derivatives presumably act with a mechanism of action different than that of the clinically approved platinum drugs. For comparison, we also synthesized Pd-\u019e3-allyl derivatives, which generally showed a slightly higher activity towards ovarian cancer cells and lower activity towards breast cancer cells with respect to their Pd-indenyl congeners.<\/jats:p>","DOI":"10.3390\/molecules29020345","type":"journal-article","created":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T05:47:21Z","timestamp":1704865641000},"page":"345","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Rational Design of Palladium(II) Indenyl and Allyl Complexes Bearing Phosphine and Isocyanide Ancillary Ligands with Promising Antitumor Activity"],"prefix":"10.3390","volume":"29","author":[{"given":"Enrica","family":"Bortolamiol","sequence":"first","affiliation":[{"name":"Department of Molecular Sciences and Nanosystems, Universit\u00e0 Ca\u2019 Foscari, Campus Scientifico, Via Torino 155, 30174 Venezia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleonora","family":"Botter","sequence":"additional","affiliation":[{"name":"Department of Molecular Sciences and Nanosystems, Universit\u00e0 Ca\u2019 Foscari, Campus Scientifico, Via Torino 155, 30174 Venezia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Cavarzerani","sequence":"additional","affiliation":[{"name":"Department of Molecular Sciences and Nanosystems, Universit\u00e0 Ca\u2019 Foscari, Campus Scientifico, Via Torino 155, 30174 Venezia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5299-994X","authenticated-orcid":false,"given":"Matteo","family":"Mauceri","sequence":"additional","affiliation":[{"name":"Department of Molecular Sciences and Nanosystems, Universit\u00e0 Ca\u2019 Foscari, Campus Scientifico, Via Torino 155, 30174 Venezia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Demitri","sequence":"additional","affiliation":[{"name":"Elettra-Sincrotrone Trieste, Area Science Park, S.S. 14 Km 163.5 Basovizza, 34149 Trieste, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3400-4363","authenticated-orcid":false,"given":"Flavio","family":"Rizzolio","sequence":"additional","affiliation":[{"name":"Department of Molecular Sciences and Nanosystems, Universit\u00e0 Ca\u2019 Foscari, Campus Scientifico, Via Torino 155, 30174 Venezia, Italy"},{"name":"Pathology Unit, Department of Molecular Biology and Translational Research, Centro di Riferimento Oncologico di Aviano (CRO), Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Via Franco Gallini 2, 33081 Aviano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiano","family":"Visentin","sequence":"additional","affiliation":[{"name":"Department of Molecular Sciences and Nanosystems, Universit\u00e0 Ca\u2019 Foscari, Campus Scientifico, Via Torino 155, 30174 Venezia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7345-9670","authenticated-orcid":false,"given":"Thomas","family":"Scattolin","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Chimiche, Universit\u00e0 Degli Studi di Padova, Via Marzolo 1, 35131 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,1,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2544","DOI":"10.1039\/D1CS00468A","article-title":"Metallodrugs in Cancer Nanomedicine","volume":"51","author":"Wang","year":"2022","journal-title":"Chem. 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