{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T20:50:38Z","timestamp":1790887838524,"version":"4.1.0"},"reference-count":72,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2024,1,23]],"date-time":"2024-01-23T00:00:00Z","timestamp":1705968000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Conditions in the gastrointestinal tract and microbial metabolism lead to biotransformation of parent, native phenolic compounds from apples into different chemical forms. The aim of this work was to review current knowledge about the forms of phenolic compounds from apples in the gastrointestinal tract and to connect it to their potential beneficial effects, including the mitigation of health problems of the digestive tract. Phenolic compounds from apples are found in the gastrointestinal tract in a variety of forms: native (flavan-3-ols, phenolic acids, flavonols, dihydrochalcones, and anthocyanins), degradation products, various metabolites, and catabolites. Native forms can show beneficial effects in the stomach and small intestine and during the beginning phase of digestion in the colon. Different products of degradation and phase II metabolites can be found in the small intestine and colon, while catabolites might be important for bioactivities in the colon. Most studies connect beneficial effects for different described health problems to the whole apple or to the amount of all phenolic compounds from apples. This expresses the influence of all native polyphenols from apples on beneficial effects. However, further studies of the peculiar compounds resulting from native phenols and their effects on the various parts of the digestive tract could provide a better understanding of the specific derivatives with bioactivity in humans.<\/jats:p>","DOI":"10.3390\/molecules29030568","type":"journal-article","created":{"date-parts":[[2024,1,24]],"date-time":"2024-01-24T07:42:16Z","timestamp":1706082136000},"page":"568","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Phenolic Compounds from Apples: From Natural Fruits to the Beneficial Effects in the Digestive System"],"prefix":"10.3390","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4846-327X","authenticated-orcid":false,"given":"Lidija","family":"Jakobek","sequence":"first","affiliation":[{"name":"Faculty of Food Technology Osijek, Josip Juraj Strossmayer University of Osijek, Franje Kuha\u010da 18, HR 31000 Osijek, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0804-1280","authenticated-orcid":false,"given":"Petra","family":"Mati\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Food Technology Osijek, Josip Juraj Strossmayer University of Osijek, Franje Kuha\u010da 18, HR 31000 Osijek, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,1,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"408","DOI":"10.3945\/an.111.000513","article-title":"A comprehensive review of apples and apple components and their relationship to human health","volume":"2","author":"Hyson","year":"2011","journal-title":"Adv. Nutr."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1021\/acs.jafc.0c06426","article-title":"Dietary supplementation of apple phlorizin attenuates the redox state related to gut microbiota homeostasis in C57BL\/6J mice fed with a high-fat diet","volume":"69","author":"Liu","year":"2021","journal-title":"J. Agric. Food Chem."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Qian, Q., Qiu, D., Wu, Z., Yang, H., Xie, Y., Li, S., Yin, Y., and Li, X. (2023). Apple polyphenol extract alleviates DSS-induced ulcerative colitis and linked behavioral disorders via regulating the gut-brain axis. Food Biosci., 53.","DOI":"10.1016\/j.fbio.2023.102720"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.foodchem.2011.02.052","article-title":"Total phenolics, flavonoids, anthocyanins and antioxidant activity following simulated gastro-intestinal digestion and dialysis of apple varieties: Bioaccessibility and potential uptake","volume":"128","author":"Bouayed","year":"2011","journal-title":"Food Chem."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1016\/j.foodchem.2011.10.030","article-title":"Bioaccessible and dialysable polyphenols in selected apple varieties following in vitro digestion vs. their native patterns","volume":"131","author":"Bouayed","year":"2012","journal-title":"Food Chem."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"3519","DOI":"10.1016\/j.foodchem.2013.06.051","article-title":"In vitro bioaccessibility, bioavailability and plasma protein interaction of polyphenols from Annurca apple (M. pumila Miller cv Annurca)","volume":"141","author":"Tenore","year":"2013","journal-title":"Food Chem."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1016\/j.freeradbiomed.2020.09.007","article-title":"Plasma pharmacokinetics of (poly)phenol metabolites and catabolites after ingestion of orange juice by endurance trained men","volume":"160","author":"Clifford","year":"2020","journal-title":"Free Radical Biol. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.tifs.2020.10.033","article-title":"Recent advances on dietary polyphenol\u2019s potential roles in Celiac Disease","volume":"107","author":"Dias","year":"2021","journal-title":"Trends Food Sci. Technol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.cofs.2017.09.004","article-title":"Nutrikinetic assessment of polyphenol exposure","volume":"16","author":"Jacobs","year":"2017","journal-title":"Curr. Opin. Food Sci."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1002\/mnfr.200900194","article-title":"Absorption, metabolism, and excretion of green tea flavan-3-ols in humans with an ileostomy","volume":"54","author":"Stalmach","year":"2010","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Koutsos, A., Lima, M., Conterno, L., Gasperotti, M., Bianchi, M., Fava, F., Vrhovsek, U., Lovegrove, J.A., and Tuohy, K.M. (2017). Effects of commercial apple varieties on human gut microbiota composition and metabolic output using an in vitro colonic model. Nutrients, 9.","DOI":"10.3390\/nu9060533"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.jfca.2014.05.004","article-title":"Phenolic and mineral profiles of four Balkan indigenous apple cultivars monitored at two different maturity stages","volume":"35","year":"2014","journal-title":"J. Food Compos. Anal."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.jff.2009.12.004","article-title":"Characterization of traditional and exotic apple varieties from Portugal. Part 1.\u2014Nutritional, phytochemical and sensory evaluation","volume":"2","author":"Feliciano","year":"2010","journal-title":"J. Funct. Food"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"4268","DOI":"10.1016\/j.chroma.2009.01.046","article-title":"Separation and identification of polyphenols in apple pomace by high-speed counter-current chromatography and high-performance liquid chromatography coupled with mass spectrometry","volume":"1216","author":"Cao","year":"2009","journal-title":"J. Chromatogr. A"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/1752-153X-8-45","article-title":"Polyphenols profile and antioxidant activity of skin and pulp of a rare apple from Marche region (Italy)","volume":"8","author":"Giomaro","year":"2014","journal-title":"Chem. Cent. J."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.jfca.2008.03.004","article-title":"Polyphenol composition and total antioxidant capacity of selected apple genotypes for processing","volume":"21","author":"Khanizadeh","year":"2008","journal-title":"J. Food Compos. Anal."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.jff.2019.03.009","article-title":"Young apple polyphenols postpone starch digestion in vitro and in vivo","volume":"56","author":"Li","year":"2019","journal-title":"J. Funct. Food"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.foodchem.2019.05.027","article-title":"Ancient apple cultivars from Garfagnana (Tuscany, Italy): A potential sourcefor \u2018nutrafruit\u2019 production","volume":"294","author":"Landi","year":"2019","journal-title":"Food Chem."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"4598","DOI":"10.1021\/jf803961f","article-title":"Three-year comparison of the polyphenol contents and antioxidant capacities in organically and conventionally produced apples (Malus domestica Bork. Cultivar Golden Delicious)","volume":"57","author":"Stracke","year":"2009","journal-title":"J. Agric. Food Chem."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"6520","DOI":"10.1021\/jf800510j","article-title":"Polyphenolic compounds and antioxidant activity of new and old apple varieties","volume":"56","author":"Laskowski","year":"2008","journal-title":"J. Agric. Food Chem."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.lwt.2019.05.006","article-title":"The antioxidant property and \u03b1-amylase inhibition activity of young apple polyphenols are related with apple varieties","volume":"111","author":"Zhao","year":"2019","journal-title":"LWT-Food Sci. Technol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1007\/s11130-015-0497-2","article-title":"Red-fleshed apples: Old autochthonous fruits as a novel source of anthocyanin antioxidants","volume":"70","author":"Faramarzi","year":"2015","journal-title":"Plant Food Hum. Nutr."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"130283","DOI":"10.1016\/j.foodchem.2021.130283","article-title":"Interactions of polyphenols from traditional apple varieties \u2018Bobovac\u2019, \u2018Ljepocvjetka\u2019 and \u2018Crvenka\u2019 with \u03b2-Glucan during in vitro simulated digestion","volume":"363","author":"Jakobek","year":"2021","journal-title":"Food Chem."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Jakobek, L., I\u0161tuk, J., Barron, A., and Mati\u0107, P. (2023). Bioactive phenolic compounds from apples during simulated in vitro gastrointestinal digestion: Kinetics of their release. Appl. Sci., 13.","DOI":"10.3390\/app13148434"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Graziani, G., Gaspari, A., Di Vaio, C., Cirillo, A., Ronca, C.L., Grosso, M., and Ritieni, A. (2021). Assessment of in vitro bioaccessibility of polyphenols from Annurca, Limoncella, Red Delicious, and Golden Delicious apples using a sequential enzymatic digestion model. Antioxidants, 10.","DOI":"10.3390\/antiox10040541"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"10605","DOI":"10.1021\/jf071942r","article-title":"Polyphenols are intensively metabolized in the human gastrointestinal tract after apple juice consumption","volume":"55","author":"Kahle","year":"2007","journal-title":"J. Agric. Food Chem."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2892","DOI":"10.1021\/jf063386r","article-title":"Apple polyphenols and products formed in the gut differently inhibit survival of human cell lines derived from colon adenoma (LT97) and carcinoma (HT29)","volume":"55","author":"Veeriah","year":"2007","journal-title":"J. Agric. Food Chem."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1136\/gut.29.8.1035","article-title":"Measurement of gastrointestinal pH profiles in normal ambulant human subjects","volume":"29","author":"Evans","year":"1988","journal-title":"Gut"},{"key":"ref_29","first-page":"183","article-title":"Intraluminal pH of the human gastrointestinal tract","volume":"46","author":"Fallingborg","year":"1999","journal-title":"Dan. Med. Bull."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1136\/gut.48.4.571","article-title":"Intestinal luminal pH in inflammatory bowel disease: Possible determinants and implications for therapy with aminosalicylates and other drugs","volume":"48","author":"Nugent","year":"2001","journal-title":"Gut"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"102486","DOI":"10.1016\/j.ifset.2020.102486","article-title":"Impact of an in vitro dynamic gastrointestinal digestion on phenolic compounds and antioxidant capacity of apple treated by high-pressure processing","volume":"66","author":"Balderas","year":"2020","journal-title":"Innov. Food Sci. Emerg."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Zahid, H.F., Ali, A., Ranadheera, C.S., Fang, Z., and Ajlouni, S. (2023). Identification of phenolics profile in freeze-dried apple peel and their bioactivities during in vitro digestion and colonic fermentation. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24021514"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1002\/mnfr.201000252","article-title":"Colonic availability of polyphenols and D-(-)-quinic acid after apple smoothie consumption","volume":"55","author":"Hagl","year":"2011","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"6459","DOI":"10.1021\/jf200553s","article-title":"Apple peel polyphenols protect against gastrointestinal mucosa alterations induced by indomethacin in rats","volume":"59","author":"Speisky","year":"2011","journal-title":"J. Agric. Food Chem."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"7172","DOI":"10.1021\/jf100274g","article-title":"In vitro and in vivo effects of apple polyphenols against Helicobacter pylori","volume":"58","author":"Pastene","year":"2010","journal-title":"J. Agric. Food Chem."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Pollini, L., Juan-Garc\u00eda, A., Blasi, F., Ma\u00f1es, J., Cossignani, L., and Juan, C. (2022). Assessing bioaccessibility and bioavailability in vitro of phenolic compounds from freeze-dried apple pomace by LC-Q-TOF-MS. Food Biosci., 48.","DOI":"10.1016\/j.fbio.2022.101799"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"103714","DOI":"10.1016\/j.jff.2019.103714","article-title":"Bioaccessibility and catabolism of phenolic compounds from jaboticaba (Myrciaria trunciflora) fruit peel during in vitro gastrointestinal digestion and colonic fermentation","volume":"65","author":"Quatrin","year":"2020","journal-title":"J. Funct. Food"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"6310","DOI":"10.1021\/jf8005068","article-title":"Antioxidant effectiveness of phenolic apple juice extracts and their gut fermentation products in the human colon carcinoma cell line Caco-2","volume":"56","author":"Bellion","year":"2008","journal-title":"J. Agric. Food Chem."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1093\/jn\/136.5.1192","article-title":"Chlorogenic acid is absorbed in its intact form in the stomach of rats","volume":"136","author":"Lafay","year":"2006","journal-title":"J. Nutr."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1093\/jn\/131.1.66","article-title":"Chlorogenic acid and caffeic acid are absorbed in humans","volume":"131","author":"Olthof","year":"2001","journal-title":"J. Nutr."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"5679","DOI":"10.1021\/jf010668c","article-title":"Esterase activity able to hydrolyze dietary antioxidant hydroxycinnamates is distributed along the intestine of mammals","volume":"49","author":"Andreasen","year":"2001","journal-title":"J. Agric. Food Chem."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1128\/AEM.02093-07","article-title":"Bacterial cinnamoyl esterase activity screening for the production of a novel functional food product","volume":"74","author":"Guglielmetti","year":"2008","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.foodchem.2007.10.084","article-title":"Antiulcerative properties of crude polyphenols and juice of apple, and Chinese quince extracts","volume":"108","author":"Hamauzu","year":"2008","journal-title":"Food Chem."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1021\/jf052236y","article-title":"Antioxidant and antiulcerative properties of phenolics from chinese quince, quince, and apple fruits","volume":"54","author":"Hamauzu","year":"2006","journal-title":"J. Agric. Food Chem."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"119370","DOI":"10.1016\/j.lfs.2021.119370","article-title":"Mechanistic insights into the protective effects of chlorogenic acid against indomethacin-induced gastric ulcer in rats: Modulation of the cross talk between autophagy and apoptosis signaling","volume":"275","author":"Ahmed","year":"2021","journal-title":"Life Sci."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"7743","DOI":"10.1021\/jf9006592","article-title":"In vitro inhibitory effect of apple peel extract on the growth of Helicobacter pylori and respiratory burst induced on human neutrophils","volume":"57","author":"Pastene","year":"2009","journal-title":"J. Agric. Food Chem."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1021\/jf8025698","article-title":"Association between polymerization degree of apple peel polyphenols and inhibition of Helicobacter pylori urease","volume":"57","author":"Pastene","year":"2009","journal-title":"J. Agric. Food Chem."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.freeradbiomed.2005.04.021","article-title":"Apples increase nitric oxide production by human saliva at the acidic pH of the stomach: A new biological function for polyphenols with a catechol group?","volume":"39","author":"Peri","year":"2005","journal-title":"Free Radical Biol. Med."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.foodchem.2016.03.093","article-title":"Interactions between polyphenols in thinned young apples and porcine pancreatic \u03b1-amylase: Inhibition, detailed kinetics and fluorescence quenching","volume":"208","author":"Sun","year":"2016","journal-title":"Food Chem."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.foodchem.2019.01.087","article-title":"Mechanism of binding interactions between young apple polyphenols and porcine pancreatic \u03b1-amylase","volume":"283","author":"Sun","year":"2019","journal-title":"Food Chem."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Gong, T., Yang, X., Bai, F., Li, D., Zhao, T., Zhang, J., Sun, L., and Guo, Y. (2020). Young apple polyphenols as natural \u03b1-glucosidase inhibitors: In vitro and in silico studies. Bioorg Chem., 96.","DOI":"10.1016\/j.bioorg.2020.103625"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.diabres.2017.03.028","article-title":"Chronic administration of apple polyphenols ameliorates hyperglycaemia in high-normal and borderline subjects: A randomised, placebo-controlled trial","volume":"129","author":"Shoji","year":"2017","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"11501","DOI":"10.1021\/jf202621d","article-title":"Apple peel polyphenol extract protects against indomethacin-induced damage in Caco-2 cells by preventing mitochondrial complex I inhibition","volume":"59","author":"Gotteland","year":"2011","journal-title":"J. Agric. Food Chem."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1021\/acs.jafc.9b01687","article-title":"Exploring the molecular pathways behind the effects of nutrients and dietary polyphenols on gut microbiota and intestinal permeability: A perspective on the potential of metabolomics and future clinical applications","volume":"68","author":"Peron","year":"2020","journal-title":"J. Agr. Food Chem."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"11217","DOI":"10.1021\/acs.jafc.3c03564","article-title":"In vitro and in vivo evaluation of chlorogenic acid-encapsulated lignin on patulin adsorption and alleviation of patulin-induced colonic damage","volume":"71","author":"Sun","year":"2023","journal-title":"J. Agric. Food Chem."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.dld.2012.01.009","article-title":"Apple polyphenols extract (APE) improves colon damage in a rat model of colitis","volume":"44","author":"Mazzone","year":"2012","journal-title":"Digest Liver Dis."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Due\u00f1as, M., Mu\u00f1oz-Gonz\u00e1lez, I., Cueva, C., Jim\u00e9nez-Gir\u00f3n, A., S\u00e1nchez-Pat\u00e1n, F., Santos-Buelga, C., Moreno-Arribas, M.V., and Bartolom\u00e9, B. (2015). A survey of modulation of gut microbiota by dietary polyphenols. Biomed. Res. Int., 2015.","DOI":"10.1155\/2015\/850902"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1021\/acs.jafc.1c07258","article-title":"Apple polyphenols extracts ameliorate high carbohydrate diet-induced body weight gain by regulating the gut microbiota and appetite","volume":"70","author":"Wang","year":"2022","journal-title":"J. Agric. Food Chem."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"6829","DOI":"10.1021\/acs.jafc.1c02532","article-title":"Apple polyphenol extract improves high-fat diet-induced hepatic steatosis by regulating bile acid synthesis and gut microbiota in C57BL\/6 Male Mice","volume":"69","author":"Li","year":"2021","journal-title":"J. Agric. Food Chem."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"10352","DOI":"10.1021\/acs.jafc.9b04870","article-title":"Levels of fecal procyanidins and changes in microbiota and metabolism in mice fed a high-fat diet supplemented with apple peel","volume":"67","author":"Elkahoui","year":"2019","journal-title":"J. Agric. Food Chem."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"10269","DOI":"10.1021\/jf0618168","article-title":"Physiological effects of extraction juices from apple, grape, and red beet pomaces in rats","volume":"54","author":"Sembries","year":"2006","journal-title":"J. Agric. Food Chem."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"7576","DOI":"10.1021\/acs.jafc.2c02495","article-title":"Apple polyphenols improve intestinal antioxidant capacity and barrier function by activating the Nrf2\/Keap1 signaling pathway in a pig model","volume":"70","author":"Huang","year":"2022","journal-title":"J. Agric. Food Chem."},{"key":"ref_63","first-page":"360","article-title":"The potential chemo-preventive roles of Malus domestica against the risk of colorectal cancer: A suggestive insight into clinical application","volume":"52","year":"2022","journal-title":"Clin. Nutr."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"108418","DOI":"10.1016\/j.jnutbio.2020.108418","article-title":"Consumption evaluation of one apple flesh a day in the initial phases prior to adenoma\/adenocarcinoma in an azoxymethane rat colon carcinogenesis model","volume":"83","author":"Motilva","year":"2020","journal-title":"J. Nutr. Biochem."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"2622","DOI":"10.1093\/jn\/137.12.2622","article-title":"Annurca apple polyphenols have potent demethylating activity and can reactivate silenced tumor suppressor genes in colorectal cancer cells1,2","volume":"137","author":"Fini","year":"2007","journal-title":"J. Nutr."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.jff.2014.10.031","article-title":"Apple polyphenol inhibits colon carcinoma metastasis via disrupting Snail binding to focal adhesion kinase","volume":"12","author":"Hung","year":"2015","journal-title":"J. Funct. Food"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1021\/jf063078t","article-title":"Cloudy apple juice is more effective than apple polyphenols and an apple juice derived cloud fraction in a rat model of colon carcinogenesis","volume":"55","author":"Barth","year":"2007","journal-title":"J. Agric. Food Chem."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"4120","DOI":"10.1021\/jf904010a","article-title":"Apple proanthocyanidins do not reduce the induction of preneoplastic lesions in the colon of rats associated with human microbiota","volume":"58","author":"Lhoste","year":"2010","journal-title":"J. Agric. Food Chem."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"9177","DOI":"10.1021\/jf201950y","article-title":"Chemical composition of natural and polyphenol-free apple pomace and the effect of this dietary ingredient on intestinal fermentation and serum lipid parameters in rats","volume":"59","author":"Kosmala","year":"2011","journal-title":"J. Agric. Food Chem."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Licht, T.R., Hansen, M., Bergstr\u00f6m, A., Poulsen, M., Krath, B.N., Markowski, J., Dragsted, L.O., and Wilcks, A. (2010). Effects of apples and specific apple components on the cecal environment of conventional rats: Role of apple pectin. BMC Microbiol., 10.","DOI":"10.1186\/1471-2180-10-13"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1093\/jn\/133.6.1860","article-title":"Apple pectin and a polyphenol-rich apple concentrate are more effective together than separately on cecal fermentations and plasma lipids in rats","volume":"133","author":"Aprikian","year":"2003","journal-title":"J. Nutr."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"115726","DOI":"10.1016\/j.carbpol.2019.115726","article-title":"Apple polysaccharide protects ICR mice against colitis associated colorectal cancer through the regulation of microbial dysbiosis","volume":"230","author":"Li","year":"2020","journal-title":"Carbohy Polym."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/29\/3\/568\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T13:48:09Z","timestamp":1760104089000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/29\/3\/568"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,23]]},"references-count":72,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2024,2]]}},"alternative-id":["molecules29030568"],"URL":"https:\/\/doi.org\/10.3390\/molecules29030568","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,23]]}}}