{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T06:16:58Z","timestamp":1790662618290,"version":"4.1.0"},"reference-count":39,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2024,1,26]],"date-time":"2024-01-26T00:00:00Z","timestamp":1706227200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"program in Sichuan Province\u2019s Science and Technology Foundation","award":["2023YFN0012"],"award-info":[{"award-number":["2023YFN0012"]}]},{"name":"program in Sichuan Province\u2019s Science and Technology Foundation","award":["2019YFN0178"],"award-info":[{"award-number":["2019YFN0178"]}]},{"name":"program in Sichuan Province\u2019s Science and Technology Foundation","award":["1+9KJGG007"],"award-info":[{"award-number":["1+9KJGG007"]}]},{"name":"key research and development program of Sichuan Province Science and Technology Foundation","award":["2023YFN0012"],"award-info":[{"award-number":["2023YFN0012"]}]},{"name":"key research and development program of Sichuan Province Science and Technology Foundation","award":["2019YFN0178"],"award-info":[{"award-number":["2019YFN0178"]}]},{"name":"key research and development program of Sichuan Province Science and Technology Foundation","award":["1+9KJGG007"],"award-info":[{"award-number":["1+9KJGG007"]}]},{"name":"1 + 9 unveiling of tackling key scientific and technological problems in functional food core technology at the Sichuan Academy of Agricultural Sciences","award":["2023YFN0012"],"award-info":[{"award-number":["2023YFN0012"]}]},{"name":"1 + 9 unveiling of tackling key scientific and technological problems in functional food core technology at the Sichuan Academy of Agricultural Sciences","award":["2019YFN0178"],"award-info":[{"award-number":["2019YFN0178"]}]},{"name":"1 + 9 unveiling of tackling key scientific and technological problems in functional food core technology at the Sichuan Academy of Agricultural Sciences","award":["1+9KJGG007"],"award-info":[{"award-number":["1+9KJGG007"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Neurodegenerative diseases (NDDs) are mainly induced by oxidative stress which produces excessive reactive oxygen species (ROS). Quercetin (QU) is a potent antioxidant with some effects on NDDs. This study prepared and characterized a novel glucose-modified QU liposome (QU\u2013Glu\u2013Lip), aiming not only to overcome QU\u2019s poor water solubility and bioavailability but also to deliver more QU to brain tissue to enhance its neuroprotective effect. QU\u2013Glu\u2013Lip possessed encapsulation efficiency (EE) of 89.9%, homogenous particle sizes (116\u2013124 nm), small PDI value (&lt;0.3), zeta value \u22121.363 \u00b1 0.437 mV, proper pH and salt stability, and proper cytotoxicity. The glucose-modified liposome penetrated the blood\u2013brain barrier (BBB) mediated via the glucose transporter 1 (GLUT1) and was taken by neuronal cells more efficiently than liposome without glucose, according to bEnd.3 and PC12 cell tests. QU\u2013Glu\u2013Lip attenuated H2O2-induced oxidative damage to PC12 with higher cell viability (88.42%) and lower intracellular ROS compared to that of QU. QU\u2013Glu\u2013Lip had higher brain target ability and delivered more QU to neuronal cells, effectively exerting the antioxidative neuroprotection effect. There is potential for the QU\u2013Glu\u2013Lip application for more effective treatment of NDDs.<\/jats:p>","DOI":"10.3390\/molecules29030607","type":"journal-article","created":{"date-parts":[[2024,1,26]],"date-time":"2024-01-26T10:54:27Z","timestamp":1706266467000},"page":"607","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["A Novel Quercetin Encapsulated Glucose Modified Liposome and Its Brain-Target Antioxidative Neuroprotection Effects"],"prefix":"10.3390","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8951-1533","authenticated-orcid":false,"given":"Jian","family":"Chen","sequence":"first","affiliation":[{"name":"Institute of Agro-Products Processing Science and Technology, Institute of Food Nutrition and Health, Sichuan Academy of Agricultural Sciences, Chengdu 610066, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinxia","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiyun","family":"Yu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyan","family":"Yang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Xia","sequence":"additional","affiliation":[{"name":"Institute of Agro-Products Processing Science and Technology, Institute of Food Nutrition and Health, Sichuan Academy of Agricultural Sciences, Chengdu 610066, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junlin","family":"Deng","sequence":"additional","affiliation":[{"name":"Institute of Agro-Products Processing Science and Technology, Institute of Food Nutrition and Health, Sichuan Academy of Agricultural Sciences, Chengdu 610066, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8321-5741","authenticated-orcid":false,"given":"Manyou","family":"Yu","sequence":"additional","affiliation":[{"name":"Institute of Agro-Products Processing Science and Technology, Institute of Food Nutrition and Health, Sichuan Academy of Agricultural Sciences, Chengdu 610066, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuoya","family":"Xiang","sequence":"additional","affiliation":[{"name":"Institute of Agro-Products Processing Science and Technology, Institute of Food Nutrition and Health, Sichuan Academy of Agricultural Sciences, Chengdu 610066, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Gan","sequence":"additional","affiliation":[{"name":"Institute of Agro-Products Processing Science and Technology, Institute of Food Nutrition and Health, Sichuan Academy of Agricultural Sciences, Chengdu 610066, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boyu","family":"Zhu","sequence":"additional","affiliation":[{"name":"Institute of Agro-Products Processing Science and Technology, Institute of Food Nutrition and Health, Sichuan Academy of Agricultural Sciences, Chengdu 610066, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Wu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Yang","sequence":"additional","affiliation":[{"name":"Institute of Agro-Products Processing Science and Technology, Institute of Food Nutrition and Health, Sichuan Academy of Agricultural Sciences, Chengdu 610066, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,1,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"93","DOI":"10.5114\/fn.2020.96707","article-title":"What causes neurodegenerative disease?","volume":"58","author":"Armstrong","year":"2020","journal-title":"Folia Neuropathol."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Kulikova, O., Troshev, D., Berezhnoy, D., Stvolinsky, S., Timoshina, Y., Abaimov, D., Muzychuk, O., Latanov, A., and Fedorova, T. 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