{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T04:47:41Z","timestamp":1783399661299,"version":"3.54.6"},"reference-count":70,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2024,2,5]],"date-time":"2024-02-05T00:00:00Z","timestamp":1707091200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Institutes of Health\u2019s Center of Biomedical Research Excellence Program","award":["P20GM103646"],"award-info":[{"award-number":["P20GM103646"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>A new tridentate Cu2+ complex based on (E)-1-(pyridin-2-yl)-N-(quinolin-8-yl)methanimine (PQM) was generated and characterized to support the activation of diazo compounds for the formation of new C\u2013N bonds. This neutral Schiff base ligand was structurally characterized to coordinate with copper(II) in an equatorial fashion, yielding a distorted octahedral complex. Upon characterization, this copper(II) complex was used to catalyze an efficient and cost-effective protocol for C\u2013N bond formation between N-nucleophiles and copper carbene complexes arising from the activation of diazo carbonyl compounds. A substrate scope of approximately 15 different amine-based substrates was screened, yielding 2\u00b0 or 3\u00b0 amine products with acceptable to good yields under mild reaction conditions. Reactivity towards phenol and thiophenol were also screened, showing relatively weak C\u2013O or C\u2013S bond formation under optimized conditions.<\/jats:p>","DOI":"10.3390\/molecules29030730","type":"journal-article","created":{"date-parts":[[2024,2,6]],"date-time":"2024-02-06T07:50:12Z","timestamp":1707205812000},"page":"730","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Aminoquinoline-Based Tridentate (NNN)-Copper Catalyst for C\u2013N Bond-Forming Reactions from Aniline and Diazo Compounds"],"prefix":"10.3390","volume":"29","author":[{"given":"Mohsen","family":"Teimouri","sequence":"first","affiliation":[{"name":"Department of Chemistry, Mississippi State University, Starkville, MS 39762, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selvam","family":"Raju","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Mississippi State University, Starkville, MS 39762, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Acheampong","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Mississippi State University, Starkville, MS 39762, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison N.","family":"Schmittou","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, The University of Alabama, 3097D Shelby Hall, Tuscaloosa, AL 35487, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Donnadieu","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Mississippi State University, Starkville, MS 39762, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2365-1175","authenticated-orcid":false,"given":"David O.","family":"Wipf","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Mississippi State University, Starkville, MS 39762, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7432-6332","authenticated-orcid":false,"given":"Brad S.","family":"Pierce","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, The University of Alabama, 3097D Shelby Hall, Tuscaloosa, AL 35487, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6093-5172","authenticated-orcid":false,"given":"Sean L.","family":"Stokes","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Mississippi State University, Starkville, MS 39762, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph P.","family":"Emerson","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Mississippi State University, Starkville, MS 39762, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,2,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2066","DOI":"10.1021\/acs.accounts.5b00140","article-title":"Developing Mononuclear Copper\u2013Active-Oxygen Complexes Relevant to Reactive Intermediates of Biological Oxidation Reactions","volume":"48","author":"Itoh","year":"2015","journal-title":"Acc. 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