{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T20:26:05Z","timestamp":1782332765777,"version":"3.54.5"},"reference-count":86,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2024,2,8]],"date-time":"2024-02-08T00:00:00Z","timestamp":1707350400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100018712","name":"\u201cIuliu Hatieganu\u201d University of Medicine and Pharmacy Cluj-Napoca","doi-asserted-by":"publisher","award":["35145\/17.12.2021"],"award-info":[{"award-number":["35145\/17.12.2021"]}],"id":[{"id":"10.13039\/501100018712","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Endometriosis is a common gynecological condition with a complex physio-pathological background. This study aimed to assess the role of Rubus idaeus leaf extract (RiDE) as a potential therapeutic agent in reducing the size of the endometriotic lesions and modulate the plasma expression of MMP-2, MMP-9, and TGF-\u03b21. The endometriotic lesions were induced in a rat model by the autologous transplant of endometrium. Thirty-six female rats, Wistar breed, with induced endometriosis, were divided into four groups and underwent treatment for 28 days. The CTRL group received 0.5 mL\/day of the vehicle; the DG group received 1 mg\/kg b.w.\/day dienogest; the RiDG group received 0.25 mL\/kg b.w.\/day RiDE and the D+RiDG group received 1 mg\/kg b.w.\/day dienogest and 0.25 mL\/kg b.w.\/day RiDE, respectively. Rats\u2019 weight, endometriotic lesion diameter and grade, and plasma levels of MMP-2, MMP-9, and TGF-\u03b21 were assessed before and after treatment. The administration of RiDE in association with dienogest vs. dienogest determined a lower weight gain and a reduction in diameter of the endometriotic lesions. RiDE administration restored MMP2 and MMP9 plasma levels to initial conditions. Rubus idaeus extract may help in reducing dienogest-associated weight gain, lower the size of endometriotic lesions, and have anti-inflammatory effects through MMP2 and MMP9 reduction.<\/jats:p>","DOI":"10.3390\/molecules29040778","type":"journal-article","created":{"date-parts":[[2024,2,8]],"date-time":"2024-02-08T03:36:17Z","timestamp":1707363377000},"page":"778","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The Effect of Rubus idaeus Polyphenols Extract in Induced Endometriosis in Rats"],"prefix":"10.3390","volume":"29","author":[{"given":"Elena-Mihaela","family":"Jianu","sequence":"first","affiliation":[{"name":"Histology, Department of Morphofunctional Sciences, \u201cIuliu Ha\u0163ieganu\u201d University of Medicine and Pharmacy, Victor Babe\u0219, No 8, 400012 Cluj-Napoca, 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Department of Food Science, University of Agricultural Science and Veterinary Medicine, Calea M\u0103n\u0103\u0219tur, No 3-5, 400372 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonia-Mihaela","family":"Levai","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology, Department of Mother and Child, \u201cIuliu Hatieganu\u201d University of Medicine and Pharmacy, Victor Babe\u0219, No 8, 400012 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3706-887X","authenticated-orcid":false,"given":"Vasile","family":"Rus","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Histology and Embryology, University of Agricultural Sciences and Veterinary Medicine, Calea M\u0103n\u0103\u0219tur, No 3-5, 400372 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2342-4311","authenticated-orcid":false,"given":"Sorana D.","family":"Bolboac\u0103","sequence":"additional","affiliation":[{"name":"Department of Medical Informatics and Biostatistics, \u201cIuliu Ha\u0163ieganu\u201d University of Medicine and Pharmacy, Louis Pasteur, No 6, 400349 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roxana-Adelina","family":"\u0218tefan","sequence":"additional","affiliation":[{"name":"Histology, Department of Morphofunctional Sciences, \u201cIuliu Ha\u0163ieganu\u201d University of Medicine and Pharmacy, Victor Babe\u0219, No 8, 400012 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0844-3662","authenticated-orcid":false,"given":"M\u0103d\u0103lin Mihai","family":"Onofrei","sequence":"additional","affiliation":[{"name":"Histology, Department of Morphofunctional Sciences, \u201cIuliu Ha\u0163ieganu\u201d University of Medicine and Pharmacy, Victor Babe\u0219, No 8, 400012 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0187-3682","authenticated-orcid":false,"given":"Ionel-Daniel","family":"Nati","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology, Department of Mother and Child, \u201cIuliu Hatieganu\u201d University of Medicine and Pharmacy, Victor Babe\u0219, No 8, 400012 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioana Alexandra","family":"Stoia","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynaecology Department County Emergency Hospital, Clinicilor, No 3-5, 400006 Cluj-Napoca, 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