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The radical monofluoromethylative difunctionalization of alkenes stands out as an appealing approach to access CH2F-containing compounds. However, this strategy remains largely underdeveloped, particularly under metal-free conditions. In this study, we report on visible light-mediated three-component monofluoromethylation\/acylation of styrene derivatives employing NHC and organic photocatalyst dual catalysis. A diverse array of \u03b1-aryl-\u03b2-monofluoromethyl ketones was successfully synthesized with excellent functional group tolerance and selectivity. The mild and metal-free CH2F radical generation strategy from NaSO2CFH2 holds potential for further applications in fluoroalkyl radical chemistry.<\/jats:p>","DOI":"10.3390\/molecules29040790","type":"journal-article","created":{"date-parts":[[2024,2,8]],"date-time":"2024-02-08T09:00:02Z","timestamp":1707382802000},"page":"790","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Visible Light-Mediated Monofluoromethylation\/Acylation of Olefins by Dual Organo-Catalysis"],"prefix":"10.3390","volume":"29","author":[{"given":"Jiuli","family":"Xia","sequence":"first","affiliation":[{"name":"Key Laboratory of Functional Organic Molecule Design & Synthesis of Jilin Province, Department of Chemistry, Northeast Normal University, Changchun 130024, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunliang","family":"Guo","sequence":"additional","affiliation":[{"name":"School of Environment, Northeast Normal University, Changchun 130117, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiguang","family":"Lv","sequence":"additional","affiliation":[{"name":"Key Laboratory of Functional Organic Molecule Design & Synthesis of Jilin Province, Department of Chemistry, Northeast Normal University, Changchun 130024, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqiong","family":"Sun","sequence":"additional","affiliation":[{"name":"School of Environment, Northeast Normal University, Changchun 130117, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0201-6279","authenticated-orcid":false,"given":"Guangfan","family":"Zheng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Functional Organic Molecule Design & Synthesis of Jilin Province, Department of Chemistry, Northeast Normal University, Changchun 130024, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Functional Organic Molecule Design & Synthesis of Jilin Province, Department of Chemistry, Northeast Normal University, Changchun 130024, China"},{"name":"State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,2,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1021\/acs.jmedchem.6b01691","article-title":"The Difluoromethyl Bioisoster: Examining the \u201cLipophilic Hydrogen Bond Donor\u201d Concept","volume":"60","author":"Zafrani","year":"2017","journal-title":"J. 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