{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T17:58:47Z","timestamp":1792432727245,"version":"4.5.0"},"reference-count":46,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T00:00:00Z","timestamp":1707436800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Universidad de Buenos Aires","award":["20020220300118BA"],"award-info":[{"award-number":["20020220300118BA"]}]},{"name":"Universidad de Buenos Aires","award":["20020170100363BA"],"award-info":[{"award-number":["20020170100363BA"]}]},{"name":"Universidad de Buenos Aires","award":["PIP 11220210100168CO"],"award-info":[{"award-number":["PIP 11220210100168CO"]}]},{"name":"Universidad de Buenos Aires","award":["PICT 2307"],"award-info":[{"award-number":["PICT 2307"]}]},{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET)","award":["20020220300118BA"],"award-info":[{"award-number":["20020220300118BA"]}]},{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET)","award":["20020170100363BA"],"award-info":[{"award-number":["20020170100363BA"]}]},{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET)","award":["PIP 11220210100168CO"],"award-info":[{"award-number":["PIP 11220210100168CO"]}]},{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET)","award":["PICT 2307"],"award-info":[{"award-number":["PICT 2307"]}]},{"name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","award":["20020220300118BA"],"award-info":[{"award-number":["20020220300118BA"]}]},{"name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","award":["20020170100363BA"],"award-info":[{"award-number":["20020170100363BA"]}]},{"name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","award":["PIP 11220210100168CO"],"award-info":[{"award-number":["PIP 11220210100168CO"]}]},{"name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","award":["PICT 2307"],"award-info":[{"award-number":["PICT 2307"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Asteraceae (Compositae), commonly known as the sunflower family, is one of the largest plant families in the world and includes several species with pharmacological properties. In the search for new antiviral candidates, an in vitro screening against dengue virus (DENV) was performed on a series of dichloromethane and methanolic extracts prepared from six Asteraceae species, including Acmella bellidioides, Campuloclinium macrocephalum, Grindelia pulchella, Grindelia chiloensis, Helenium radiatum, and Viguiera tuberosa, along with pure phytochemicals isolated from Asteraceae: mikanolide (1), eupatoriopicrin (2), eupahakonenin B (3), minimolide (4), estafietin (5), 2-oxo-8-deoxyligustrin (6), santhemoidin C (7), euparin (8), jaceidin (9), nepetin (10), jaceosidin (11), eryodictiol (12), eupatorin (13), and 5-demethylsinensetin (14). Results showed that the dichloromethane extracts of C. macrocephalum and H. radiatum and the methanolic extracts prepared from C. macrocephalum and G. pulchella were highly active and selective against DENV-2, affording EC50 values of 0.11, 0.15, 1.80, and 3.85 \u00b5g\/mL, respectively, and SIs of 171.0, 18.8, &gt;17.36, and 64.9, respectively. From the pool of phytochemicals tested, compounds 6, 7, and 8 stand out as the most active (EC50 = 3.7, 3.1, and 6.8 \u00b5M, respectively; SI = 5.9, 6.7, and &gt;73.4, respectively). These results demonstrate that Asteraceae species and their chemical constituents represent valuable sources of new antiviral molecules.<\/jats:p>","DOI":"10.3390\/molecules29040814","type":"journal-article","created":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T11:42:05Z","timestamp":1707478925000},"page":"814","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Plant Extracts and Phytochemicals from the Asteraceae Family with Antiviral Properties"],"prefix":"10.3390","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0259-4047","authenticated-orcid":false,"given":"Jimena","family":"Borgo","sequence":"first","affiliation":[{"name":"Instituto de Qu\u00edmica y Metabolismo del F\u00e1rmaco (IQUIMEFA), CONICET-Universidad de Buenos Aires, Jun\u00edn 956, Piso 2, Buenos Aires C1113AAD, Argentina"},{"name":"Facultad de Farmacia y Bioqu\u00edmica, Universidad de Buenos Aires, Jun\u00edn 956, Piso 2, Buenos Aires C1113AAD, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-7001-8750","authenticated-orcid":false,"given":"Mariel S.","family":"Wagner","sequence":"additional","affiliation":[{"name":"Laboratorio de Estrategias Antivirales, Departamento de Qu\u00edmica Biol\u00f3gica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Int. G\u00fciraldes 2160, Piso 4, Buenos Aires C1428EGA, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0378-0737","authenticated-orcid":false,"given":"Laura C.","family":"Laurella","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica y Metabolismo del F\u00e1rmaco (IQUIMEFA), CONICET-Universidad de Buenos Aires, Jun\u00edn 956, Piso 2, Buenos Aires C1113AAD, Argentina"},{"name":"Facultad de Farmacia y Bioqu\u00edmica, Universidad de Buenos Aires, Jun\u00edn 956, Piso 2, Buenos Aires C1113AAD, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1970-9904","authenticated-orcid":false,"given":"Orlando G.","family":"Elso","sequence":"additional","affiliation":[{"name":"Facultad de Farmacia y Bioqu\u00edmica, Universidad de Buenos Aires, Jun\u00edn 956, Piso 2, Buenos Aires C1113AAD, Argentina"},{"name":"Unidad de Microan\u00e1lisis y M\u00e9todos F\u00edsicos Aplicados a Qu\u00edmica Org\u00e1nica (UMYMFOR), Facultad de Ciencias Exactas y Naturales, CONICET-Universidad de Buenos Aires, Ciudad Universitaria, Pabell\u00f3n 2, Piso 3, Buenos Aires C1428EGA, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana G.","family":"Selener","sequence":"additional","affiliation":[{"name":"Facultad de Farmacia y Bioqu\u00edmica, Universidad de Buenos Aires, Jun\u00edn 956, Piso 2, Buenos Aires C1113AAD, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Clavin","sequence":"additional","affiliation":[{"name":"Facultad de Farmacia y Bioqu\u00edmica, Universidad de Buenos Aires, Jun\u00edn 956, Piso 2, Buenos Aires C1113AAD, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hern\u00e1n","family":"Bach","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Tecnolog\u00eda Agropecuaria (INTA) Gobernador Guillermo Udaondo 1695 Estaci\u00f3n Experimental Agropecuaria \u00c1rea Metropolitana de Buenos Aires, EEA AMBA Udaondo, Villa Udaondo B1713AAW, Buenos Aires Province, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7409-5303","authenticated-orcid":false,"given":"C\u00e9sar A. N.","family":"Catal\u00e1n","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica Org\u00e1nica, Facultad de Bioqu\u00edmica, Qu\u00edmica y Farmacia, Universidad Nacional de Tucum\u00e1n, Ayacucho 471, San Miguel de Tucum\u00e1n T4000INI, Tucum\u00e1n Province, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0520-0226","authenticated-orcid":false,"given":"Augusto E.","family":"Bivona","sequence":"additional","affiliation":[{"name":"Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni (IDEHU), CONICET-Universidad de Buenos Aires, Jun\u00edn 956, Piso 4, Buenos Aires C1113AAD, Argentina"},{"name":"Instituto de Investigaciones en Microbiolog\u00eda y Parasitolog\u00eda M\u00e9dica (IMPaM), CONICET-Universidad de Buenos Aires, Paraguay 2155, Piso 13, Buenos Aires C1121ABG, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2356-6624","authenticated-orcid":false,"given":"Claudia S.","family":"Sep\u00falveda","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica Biol\u00f3gica de la Facultad de Ciencias Exactas y Naturales (IQUIBICEN), CONICET-Universidad de Buenos Aires, Int. G\u00fciraldes 2160, Piso 4, Buenos Aires C1428EGA, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9322-5748","authenticated-orcid":false,"given":"Valeria P.","family":"S\u00fclsen","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica y Metabolismo del F\u00e1rmaco (IQUIMEFA), CONICET-Universidad de Buenos Aires, Jun\u00edn 956, Piso 2, Buenos Aires C1113AAD, Argentina"},{"name":"Facultad de Farmacia y Bioqu\u00edmica, Universidad de Buenos Aires, Jun\u00edn 956, Piso 2, Buenos Aires C1113AAD, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,2,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Rolnik, A., and Olas, B. (2021). The Plants of the Asteraceae Family as Agents in the Protection of Human Health. Int. J. Mol. 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