{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,5]],"date-time":"2026-04-05T07:08:50Z","timestamp":1775372930876,"version":"3.50.1"},"reference-count":60,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T00:00:00Z","timestamp":1708387200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Universidad Tecnol\u00f3gica de Pereira","award":["5-21-8"],"award-info":[{"award-number":["5-21-8"]}]},{"name":"Universidad Tecnol\u00f3gica de Pereira","award":["BPIN 2020000100077"],"award-info":[{"award-number":["BPIN 2020000100077"]}]},{"DOI":"10.13039\/501100013409","name":"Universidad del Quind\u00edo, and Sistema General de Regal\u00edas de Colombia","doi-asserted-by":"publisher","award":["5-21-8"],"award-info":[{"award-number":["5-21-8"]}],"id":[{"id":"10.13039\/501100013409","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013409","name":"Universidad del Quind\u00edo, and Sistema General de Regal\u00edas de Colombia","doi-asserted-by":"publisher","award":["BPIN 2020000100077"],"award-info":[{"award-number":["BPIN 2020000100077"]}],"id":[{"id":"10.13039\/501100013409","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Toxoplasmosis is a parasitic disease caused by the protozoan Toxoplasma gondii that is highly prevalent worldwide. Although the infection is asymptomatic in immunocompetent individuals, it severely affects immunocompromised individuals, causing conditions such as encephalitis, myocarditis, or pneumonitis. The limited therapeutic efficacy of drugs currently used to treat toxoplasmosis has prompted the search for new therapeutic alternatives. The aim of this study was to determine the anti-Toxoplasma activity of extracts obtained from two species of the genus Tabebuia. Twenty-six extracts, 12 obtained from Tabebuia chrysantha and 14 from Tabebuia rosea, were evaluated by a colorimetric technique using the RH strain of T. gondii that expresses \u03b2-galactosidase. Additionally, the activity of the promising extracts and their active compounds was evaluated by flow cytometry. \u03b2-amyrin was isolated from the chloroform extract obtained from the leaves of T. rosea and displayed important anti-Toxoplasma activity. The results show that natural products are an important source of new molecules with considerable biological and\/or pharmacological activity.<\/jats:p>","DOI":"10.3390\/molecules29050920","type":"journal-article","created":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T06:50:22Z","timestamp":1708498222000},"page":"920","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["In Vitro Anti-Toxoplasma Activity of Extracts Obtained from Tabebuia rosea and Tabebuia chrysantha: The Role of \u03b2-Amyrin"],"prefix":"10.3390","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8625-2086","authenticated-orcid":false,"given":"Maria Camila","family":"Cardona-Trujillo","sequence":"first","affiliation":[{"name":"Grupo Infecci\u00f3n e Inmunidad, Facultad de Ciencias de la Salud, Universidad Tecnol\u00f3gica de Pereira, Pereira 660003, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco Javier","family":"Jim\u00e9nez-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Grupo Polifenoles, Facultad de Tecnolog\u00edas, Escuela de Qu\u00edmica, Universidad Tecnol\u00f3gica de Pereira, Pereira 660003, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luz Angela","family":"Veloza","sequence":"additional","affiliation":[{"name":"Grupo Polifenoles, Facultad de Tecnolog\u00edas, Escuela de Qu\u00edmica, Universidad Tecnol\u00f3gica de Pereira, Pereira 660003, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5410-5997","authenticated-orcid":false,"given":"Juan Carlos","family":"Sep\u00falveda-Arias","sequence":"additional","affiliation":[{"name":"Grupo Infecci\u00f3n e Inmunidad, Facultad de Ciencias de la Salud, Universidad Tecnol\u00f3gica de Pereira, Pereira 660003, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,2,20]]},"reference":[{"key":"ref_1","unstructured":"Dubey, J.P. 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