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In this study, a model rat of streptozotocin (STZ)-induced diabetes was established, and chromium picolinate (5 mg\u00b7kg\u22121) was given; the changes in blood glucose and body weight were detected before and after administration; and bone mineral density (BMD), bone morphology, bone turnover markers, inflammatory cytokines, and oxidative stress indicators were observed in each group. We found that after chromium picolinate (CP) intervention for 8 weeks, the blood glucose level was decreased; the BMD, the bone histomorphology parameters, and the pathological structure were improved; the expression of bone resorption-related proteins was downregulated; and the expression of bone formation-related proteins was upregulated. Meanwhile, serum antioxidant activity was increased, and inflammatory cytokine levels were decreased. In conclusion, CP could alleviate DOP by anti-oxidation, inhibition of bone turnover, anti-inflammation, and regulation of the OPG\/RANKL\/RANK signaling pathway. Therefore, CP has important application values for further development as a functional food or active medicine in DOP treatment.<\/jats:p>","DOI":"10.3390\/molecules29050924","type":"journal-article","created":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T06:50:22Z","timestamp":1708498222000},"page":"924","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Chromium Picolinate Regulates Bone Metabolism and Prevents Bone Loss in Diabetic Rats"],"prefix":"10.3390","volume":"29","author":[{"given":"Hongxing","family":"Zheng","sequence":"first","affiliation":[{"name":"School of Biological Science and Engineering, Shaanxi University of Technology, Hanzhong 723000, China"},{"name":"State Key Laboratory of Qinba Biological Resources and Ecological Environment, Hanzhong 723000, China"},{"name":"Shaanxi Black Organic Food Engineering Technology Research Center, Hanzhong 723000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenrui","family":"Yan","sequence":"additional","affiliation":[{"name":"School of Biological Science and Engineering, Shaanxi University of Technology, Hanzhong 723000, China"},{"name":"Qinba Mountain Area Collaborative Innovation Center of Bioresources Comprehensive Development, Hanzhong 723000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengli","family":"Shao","sequence":"additional","affiliation":[{"name":"School of Biological Science and Engineering, Shaanxi University of Technology, Hanzhong 723000, China"},{"name":"Shaanxi Provincial Key Laboratory of Resource Biology, Hanzhong 723001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanshan","family":"Qi","sequence":"additional","affiliation":[{"name":"School of Biological Science and Engineering, Shaanxi University of Technology, Hanzhong 723000, China"},{"name":"Shaanxi Migukang Biotechnology Company, Xi\u2019an 710018, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,2,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"531","DOI":"10.14348\/molcells.2022.0084","article-title":"Cellular Senescence: The Villain of Metabolic Disease?: Discovery of a distinct senescent cell population in obesity-induced metabolic dysfunction","volume":"45","author":"Lee","year":"2022","journal-title":"Mol. 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