{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:03:56Z","timestamp":1792789436083,"version":"4.5.0"},"reference-count":74,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T00:00:00Z","timestamp":1708473600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005632","name":"NCBiR","doi-asserted-by":"publisher","award":["PL-TW\/VII\/3\/2020"],"award-info":[{"award-number":["PL-TW\/VII\/3\/2020"]}],"id":[{"id":"10.13039\/501100005632","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005632","name":"NCBiR","doi-asserted-by":"publisher","award":["SUBZ.D290.23.031"],"award-info":[{"award-number":["SUBZ.D290.23.031"]}],"id":[{"id":"10.13039\/501100005632","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Wroc\u0142aw University of Environmental and Life Sciences","award":["PL-TW\/VII\/3\/2020"],"award-info":[{"award-number":["PL-TW\/VII\/3\/2020"]}]},{"name":"Wroc\u0142aw University of Environmental and Life Sciences","award":["SUBZ.D290.23.031"],"award-info":[{"award-number":["SUBZ.D290.23.031"]}]},{"name":"Wroc\u0142aw Medical University","award":["PL-TW\/VII\/3\/2020"],"award-info":[{"award-number":["PL-TW\/VII\/3\/2020"]}]},{"name":"Wroc\u0142aw Medical University","award":["SUBZ.D290.23.031"],"award-info":[{"award-number":["SUBZ.D290.23.031"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>This study presents a simple and energy-efficient self-assembly LAG synthetic method for novel water-soluble copper(I) complexes [Cu(terpy)(PTA)][PF6] (1) and [Cu(terpy)(PTA)2][PF6] (2). They were characterized by FT-IR, 1H, and 31P{1H} NMR spectroscopy, elemental analysis, and single-crystal\/powder X-ray diffraction (for 2). The X-ray analysis of compound 2 indicates a bidentate coordination mode of terpyridine to the metal center. Variable-temperature NMR tests indicate dynamic properties for terpyridine in the case of both compounds, as well as for the PTA ligands in the case of 2. Additionally, compounds 1 and 2 exhibit interesting cytotoxic activity, which was tested on normal human dermal fibroblasts (NHDFs), human lung carcinoma (A549), human breast adenocarcinoma (MCF-7), and human cervix carcinoma (HeLa) established cell lines. In comparison to the other tested compounds, complexes 1 and 2 seem to have significantly lower IC50 values against cancer cells (A549, HeLa, MCF-7), indicating their potential as prospective anticancer agents. Moreover, both compounds show no significant toxicity towards normal skin cells (NHDFs), suggesting a certain selectivity in their action on cancer cells. Cisplatin as a reference compound also exhibited considerable cytotoxicity against cancer cells but with a low level of selectivity, which could lead to unwanted effects on normal cells. Remarkably, compounds 1 and 2 exhibit up to 30 times the cytotoxic activity of cisplatin, with a six-fold lower toxicity to normal cells. They also interact strongly with human serum albumin, suggesting potential therapeutic applications. Overall, these compounds hold significant promise as potential chemotherapeutic agents.<\/jats:p>","DOI":"10.3390\/molecules29050945","type":"journal-article","created":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T08:43:48Z","timestamp":1708505028000},"page":"945","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Design, Synthesis, and Anti-Cancer Evaluation of Novel Water-Soluble Copper(I) Complexes Bearing Terpyridine and PTA Ligands"],"prefix":"10.3390","volume":"29","author":[{"given":"Piotr","family":"Smole\u0144ski","sequence":"first","affiliation":[{"name":"Faculty of Chemistry, University of Wroc\u0142aw, F. Joliot-Curie 14, 50-383 Wroc\u0142aw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Urszula","family":"\u015aliwi\u0144ska-Hill","sequence":"additional","affiliation":[{"name":"Department of Basic Chemical Sciences, Faculty of Pharmacy, Wroc\u0142aw Medical University, Borowska 211a, 50-556 Wroc\u0142aw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1216-9287","authenticated-orcid":false,"given":"Anna","family":"Kwiecie\u0144","sequence":"additional","affiliation":[{"name":"Department of Basic Chemical Sciences, Faculty of Pharmacy, Wroc\u0142aw Medical University, Borowska 211a, 50-556 Wroc\u0142aw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Woli\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Biostructure and Animal Physiology, Faculty of Veterinary Medicine, Wroc\u0142aw University of Environmental and Life Sciences, Ko\u017cuchowska 1, 51-631 Wroc\u0142aw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4296-3174","authenticated-orcid":false,"given":"Dominik","family":"Poradowski","sequence":"additional","affiliation":[{"name":"Department of Biostructure and Animal Physiology, Faculty of Veterinary Medicine, Wroc\u0142aw University of Environmental and Life Sciences, Ko\u017cuchowska 1, 51-631 Wroc\u0142aw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,2,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1038\/s41571-021-00514-z","article-title":"Planning for tomorrow: Global cancer incidence and the role of prevention 2020\u20132070","volume":"18","author":"Soerjomataram","year":"2021","journal-title":"Nat. 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