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starting material with the aim of enhancing the antimicrobial properties of this natural product. Initially, different processes were performed in order to optimize the reaction conditions to obtain a macromolecule with a high purity and yield. PTF was characterized using different techniques, such as NMR, infrared, UV-Vis, and thermogravimetric analyses. The antimicrobial activity of both PTF and thymol was evaluated against different microorganisms, including S. aureus, E. coli, P. aeruginosa, and C. albicans. The obtained MIC values showed a higher potential for PTF than the monomer thymol\u2014for example, against S. aureus (500 and 31.5 \u00b5g\u00b7mL\u22121 for thymol and PTF, respectively). Therefore, the obtained results show that the polymerization of thymol afforded more active biomaterial than the starting monomeric antimicrobial compound (thymol), suggesting that PTF is an important biomaterial.<\/jats:p>","DOI":"10.3390\/molecules29051010","type":"journal-article","created":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T03:34:04Z","timestamp":1708918444000},"page":"1010","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Thymol as Starting Material for the Development of a Biobased Material with Enhanced Antimicrobial Activity: Synthesis, Characterization, and Potential Application"],"prefix":"10.3390","volume":"29","author":[{"given":"Giovana A.","family":"Parolin","sequence":"first","affiliation":[{"name":"Laboratory of Hybrid Materials, Chemistry Department, Federal University of S\u00e3o Paulo, Diadema 09913-030, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6122-8055","authenticated-orcid":false,"given":"Vitor G.","family":"Vital","sequence":"additional","affiliation":[{"name":"Multidisciplinary Laboratory of Health and Environment Sciences, Department of Pharmaceutical Sciences, Federal University of S\u00e3o Paulo, Diadema 09913-030, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6876-7687","authenticated-orcid":false,"given":"Suzan P.","family":"de Vasconcellos","sequence":"additional","affiliation":[{"name":"Multidisciplinary Laboratory of Health and Environment Sciences, Department of Pharmaceutical Sciences, Federal University of S\u00e3o Paulo, Diadema 09913-030, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Henrique G.","family":"Lago","sequence":"additional","affiliation":[{"name":"Laboratory of Chemical Biology, Center for Natural and Human Sciences, Federal University of ABC, Santo Andre 09210-580, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2513-0592","authenticated-orcid":false,"given":"Laura O.","family":"P\u00e9res","sequence":"additional","affiliation":[{"name":"Laboratory of Hybrid Materials, Chemistry Department, Federal University of S\u00e3o Paulo, Diadema 09913-030, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,2,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1002\/pola.27647","article-title":"Antibacterial poly(ethylene terephthalate) surfaces obtained from thymyl methacrylate polymerization","volume":"53","author":"Bedel","year":"2015","journal-title":"J. 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