{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T08:34:37Z","timestamp":1791362077106,"version":"4.3.1"},"reference-count":62,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Pharma Innovations IKE","award":["7381"],"award-info":[{"award-number":["7381"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>This study aimed to characterize a Sideritis scardica extract (SidTea+TM) and investigate its effect on the physiological profile, metabolic health and redox status in healthy individuals. The chemical profile and antioxidant potential of the SidTea+TM extract were evaluated by UPLC-HRMS analysis and in vitro cell-free methods. Twenty-eight healthy adults participated in this randomized, double-blind, placebo-controlled study. Participants consumed 1500 mg\/day of SidTea+TM or a placebo for 4 weeks. At baseline and post-supplementation, participants were assessed for their anthropometric and physiological profile and provided a resting blood sample. SidTea+TM decreased (p &lt; 0.05) systolic blood pressure (\u221210.8 mmHg), mean arterial pressure (\u22124.5 mmHg), resting heart rate (\u22123.1 bpm) and handgrip strength of the non-dominant limb (\u22120.8 kg) whereas the placebo decreased (p &lt; 0.05) handgrip strength of the dominant (\u22125.8 kg) and non-dominant (\u22123.2 kg) limb. SidTea+TM also resulted in an increase (p &lt; 0.05) in estimated VO2max (+1.1 mL\/kg\/min) and a reduction (p &lt; 0.05) in \u03b3-GT and SGPT enzymatic activity in serum (\u22123.7 and \u22123.3 U\/L, respectively). Finally, SidTea+TM increased (p &lt; 0.001) total antioxidant capacity and decreased (p &lt; 0.05) lipid peroxidation levels in plasma. These results indicate that SidTea+TM is a potent and safe to use antioxidant that can elicit positive changes in indices of blood pressure, cardiorespiratory capacity, liver metabolism, and redox status in healthy adults over a 4-week supplementation period.<\/jats:p>","DOI":"10.3390\/molecules29051113","type":"journal-article","created":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T06:07:53Z","timestamp":1709273273000},"page":"1113","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Characterization of the Sideritis scardica Extract SidTea+TM and Its Effect on Physiological Profile, Metabolic Health and Redox Biomarkers in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled Study"],"prefix":"10.3390","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5062-9881","authenticated-orcid":false,"given":"Konstantinos","family":"Papanikolaou","sequence":"first","affiliation":[{"name":"Department of Physical Education and Sport Science, University of Thessaly, 42150 Trikala, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Kouloridas","sequence":"additional","affiliation":[{"name":"Department of Physical Education and Sport Science, University of Thessaly, 42150 Trikala, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5243-4378","authenticated-orcid":false,"given":"Anastasia","family":"Rosvoglou","sequence":"additional","affiliation":[{"name":"Department of Physical Education and Sport Science, University of Thessaly, 42150 Trikala, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6219-6745","authenticated-orcid":false,"given":"Athanasios","family":"Gatsas","sequence":"additional","affiliation":[{"name":"Department of Physical Education and Sport Science, University of Thessaly, 42150 Trikala, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5545-9271","authenticated-orcid":false,"given":"Kalliopi","family":"Georgakouli","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Dietetics, University of Thessaly, 42132 Trikala, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5762-8419","authenticated-orcid":false,"given":"Chariklia K.","family":"Deli","sequence":"additional","affiliation":[{"name":"Department of Physical Education and Sport Science, University of Thessaly, 42150 Trikala, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2773-7729","authenticated-orcid":false,"given":"Dimitrios","family":"Draganidis","sequence":"additional","affiliation":[{"name":"Department of Physical Education and Sport Science, University of Thessaly, 42150 Trikala, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aikaterini","family":"Argyropoulou","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy and Natural Products Chemistry, Faculty of Pharmacy, National and Kapodistrian University of Athens, 15771 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3264-6186","authenticated-orcid":false,"given":"Dimitris","family":"Michailidis","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy and Natural Products Chemistry, Faculty of Pharmacy, National and Kapodistrian University of Athens, 15771 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8475-8411","authenticated-orcid":false,"given":"Ioannis G.","family":"Fatouros","sequence":"additional","affiliation":[{"name":"Department of Physical Education and Sport Science, University of Thessaly, 42150 Trikala, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5115-9490","authenticated-orcid":false,"given":"Athanasios Z.","family":"Jamurtas","sequence":"additional","affiliation":[{"name":"Department of Physical Education and Sport Science, University of Thessaly, 42150 Trikala, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,3,1]]},"reference":[{"key":"ref_1","unstructured":"de Castro, C.O., and N\u00fa\u00f1ez, D.R. 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