{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T05:42:39Z","timestamp":1784612559739,"version":"3.55.0"},"reference-count":46,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T00:00:00Z","timestamp":1709769600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Yantai\u2019s \u201cDouble Hundred Plan\u201d","award":["fzj22022"],"award-info":[{"award-number":["fzj22022"]}]},{"name":"Yantai\u2019s \u201cDouble Hundred Plan\u201d","award":["KGIFYTU2312"],"award-info":[{"award-number":["KGIFYTU2312"]}]},{"name":"Talent Induction Program for Youth Innovation Teams in Colleges and Universities of Shandong Province","award":["fzj22022"],"award-info":[{"award-number":["fzj22022"]}]},{"name":"Talent Induction Program for Youth Innovation Teams in Colleges and Universities of Shandong Province","award":["KGIFYTU2312"],"award-info":[{"award-number":["KGIFYTU2312"]}]},{"name":"Foundation of Anhui Laboratory of Molecule-Based Materials","award":["fzj22022"],"award-info":[{"award-number":["fzj22022"]}]},{"name":"Foundation of Anhui Laboratory of Molecule-Based Materials","award":["KGIFYTU2312"],"award-info":[{"award-number":["KGIFYTU2312"]}]},{"name":"The Graduate Innovation Foundation of Yantai University","award":["fzj22022"],"award-info":[{"award-number":["fzj22022"]}]},{"name":"The Graduate Innovation Foundation of Yantai University","award":["KGIFYTU2312"],"award-info":[{"award-number":["KGIFYTU2312"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>A practical metal-free and additive-free approach for the synthesis of 6\/7\/8-membered oxacyclic ketone-fused isoxazoles\/isoxazolines tetracyclic or tricyclic structures is reported through Csp3\u2013H bond radical nitrile oxidation and the intramolecular cycloaddition of alkenyl\/alkynyl-substituted aryl methyl ketones. This convenient approach enables the simultaneous formation of isoxazole\/isoxazoline and 6\/7\/8-membered oxacyclic ketones to form polycyclic architectures by using tert-butyl nitrite (TBN) as a non-metallic radical initiator and N\u2013O fragment donor.<\/jats:p>","DOI":"10.3390\/molecules29061202","type":"journal-article","created":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T11:33:06Z","timestamp":1709811186000},"page":"1202","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["tert-Butyl Nitrite-Induced Radical Nitrile Oxidation Cycloaddition: Synthesis of Isoxazole\/Isoxazoline-Fused Benzo 6\/7\/8-membered Oxacyclic Ketones"],"prefix":"10.3390","volume":"29","author":[{"given":"Jian-Kang","family":"Cao","sequence":"first","affiliation":[{"name":"Key Laboratory of Molecular Pharmacology and Drug Evaluation, Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and 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