{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T03:48:53Z","timestamp":1791517733991,"version":"4.3.4"},"reference-count":90,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2024,3,12]],"date-time":"2024-03-12T00:00:00Z","timestamp":1710201600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004281","name":"National Science Centre (Poland)","doi-asserted-by":"publisher","award":["UMO-2021\/43\/D\/NZ3\/01440"],"award-info":[{"award-number":["UMO-2021\/43\/D\/NZ3\/01440"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004281","name":"National Science Centre (Poland)","doi-asserted-by":"publisher","award":["DEC-2021\/43\/B\/NZ7\/01938"],"award-info":[{"award-number":["DEC-2021\/43\/B\/NZ7\/01938"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>The resolution of inflammation is the primary domain of specialised pro-resolving mediators (SPMs), which include resolvins, protectins, and their forms synthesised under the influence of aspirin and the maresins. The role of these SPMs has been discussed by many authors in the literature, with particular reference to neuroinflammation and significant neurological disorders. This review discusses the role of G protein-coupled receptor 18 (GPR18), resolvin D2 (RvD2) activity, and the GPR18-RvD2 signalling axis, as well as the role of small molecule ligands of GPR18 in inflammation in various health disorders (brain injuries, neuropathic pain, neurodegenerative\/cardiometabolic\/cardiovascular\/gastrointestinal diseases, peritonitis, periodontitis, asthma and lung inflammation, Duchenne muscular dystrophy, SARS-CoV-2-induced inflammation, and placenta disorders. The idea of biological intervention through modulating GPR18 signalling is attracting growing attention because of its great therapeutic potential. With this paper, we aimed to present a comprehensive review of the most recent literature, perform a constructive view of data, and point out research gaps.<\/jats:p>","DOI":"10.3390\/molecules29061258","type":"journal-article","created":{"date-parts":[[2024,3,12]],"date-time":"2024-03-12T12:14:40Z","timestamp":1710245680000},"page":"1258","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Uncovering the Power of GPR18 Signalling: How RvD2 and Other Ligands Could Have the Potential to Modulate and Resolve Inflammation in Various Health Disorders"],"prefix":"10.3390","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2046-4879","authenticated-orcid":false,"given":"Ewelina","family":"Honkisz-Orzechowska","sequence":"first","affiliation":[{"name":"Department of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University Medical College, 9 Medyczna St., 30-688 Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8454-4440","authenticated-orcid":false,"given":"Dorota","family":"\u0141a\u017cewska","sequence":"additional","affiliation":[{"name":"Department of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University Medical College, 9 Medyczna St., 30-688 Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2725-1101","authenticated-orcid":false,"given":"Grzegorz","family":"Baran","sequence":"additional","affiliation":[{"name":"Department of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University Medical College, 9 Medyczna St., 30-688 Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6752-7443","authenticated-orcid":false,"given":"Katarzyna","family":"Kie\u0107-Kononowicz","sequence":"additional","affiliation":[{"name":"Department of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University Medical College, 9 Medyczna St., 30-688 Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,3,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1017\/S0959259807002110","article-title":"The inflammatory process in aging","volume":"16","year":"2006","journal-title":"Rev. Clin. Gerontol."},{"key":"ref_2","first-page":"620","article-title":"Mast Cell: A Multi-Functional Master Cell","volume":"6","author":"Dileepan","year":"2016","journal-title":"Front. Immunol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2619","DOI":"10.1172\/JCI124615","article-title":"The role of macrophages in the resolution of inflammation","volume":"129","author":"Watanabe","year":"2019","journal-title":"J. Clin. Investig."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1159\/000362724","article-title":"One hormone, two actions: Anti- and pro-inflammatory effects of glucocorticoids","volume":"22","author":"Cidlowski","year":"2015","journal-title":"Neuroimmunomodulation"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/s41423-021-00832-3","article-title":"Neutrophils in chronic inflammatory diseases","volume":"19","author":"Soehnlein","year":"2022","journal-title":"Cell. Mol. Immunol."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Serhan, C.N., Chiang, N., Dalli, J., and Levy, B.D. (2015). Lipid mediators in the resolution of inflammation. Cold Spring Harb. Perspect. Biol., 7.","DOI":"10.1101\/cshperspect.a016311"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1111\/j.1538-7836.2009.03396.x","article-title":"Systems approach to inflammation resolution: Identification of novel anti-inflammatory and pro-resolving mediators","volume":"7","author":"Serhan","year":"2009","journal-title":"J. Thromb. Haemost."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mam.2017.03.001","article-title":"Discovery of specialized pro-resolving mediators marks the dawn of resolution physiology and pharmacology","volume":"58","author":"Serhan","year":"2017","journal-title":"Mol. Asp. Med."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Valente, M., Dentoni, M., Bellizzi, F., Kuris, F., and Gigli, G.L. (2022). Specialized Pro-Resolving Mediators in Neuroinflammation: Overview of Studies and Perspectives of Clinical Applications. Molecules, 27.","DOI":"10.3390\/molecules27154836"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2090","DOI":"10.2174\/1389557520666200719014433","article-title":"G-Protein Coupled Receptors Involved in the Resolution of Inflammation: Ligands and Therapeutic Perspectives","volume":"20","author":"Mastromarino","year":"2020","journal-title":"Mini Rev. Med. Chem."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1006\/geno.1997.4752","article-title":"Cloning and chromosomal localization localisation of a gene (GPR18) encoding a novel seven transmembrane receptor highly expressed in spleen and testis","volume":"42","author":"Gantz","year":"1997","journal-title":"Genomics"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"4903","DOI":"10.1073\/pnas.0230374100","article-title":"The G protein-coupled receptor repertoires of human and mouse","volume":"100","author":"Vassilatis","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"3908","DOI":"10.1111\/bph.12746","article-title":"Activation of GPR18 by cannabinoid compounds: A tale of biased agonism","volume":"171","author":"Brailoiu","year":"2014","journal-title":"Br. J. Pharmacol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"3227","DOI":"10.1002\/jcb.23245","article-title":"Resolution of inflammation by N-arachidonoylglycine","volume":"112","author":"Burstein","year":"2011","journal-title":"J. Cell Biochem."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1021\/acsptsci.9b00075","article-title":"New Advances in Targeting the Resolution of Inflammation: Implications for Specialized Pro-Resolving Mediator GPCR Drug Discovery","volume":"3","author":"Park","year":"2020","journal-title":"ACS Pharmacol. Transl. Sci."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1084\/jem.20150225","article-title":"Identification of resolvin D2 receptor mediating resolution of infections and organ protection","volume":"212","author":"Chiang","year":"2015","journal-title":"J. Exp. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2657","DOI":"10.1172\/JCI97943","article-title":"Resolvins in inflammation: Emergence of the pro-resolving superfamily of mediators","volume":"128","author":"Serhan","year":"2018","journal-title":"J. Clin. Investig."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"e1835","DOI":"10.7717\/peerj.1835","article-title":"GPR18 undergoes a high degree of constitutive trafficking but is unresponsive to N-Arachidonoyl Glycine","volume":"4","author":"Finlay","year":"2016","journal-title":"PeerJ"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1021\/acsmedchemlett.0c00208","article-title":"Discovery of Tricyclic Xanthines as Agonists of the Cannabinoid-Activated Orphan G-Protein-Coupled Receptor GPR18","volume":"11","author":"Schoeder","year":"2020","journal-title":"ACS Med. Chem. Lett."},{"key":"ref_20","first-page":"103","article-title":"Molecular Targets of the Phytocannabinoids: A Complex Picture","volume":"103","author":"Morales","year":"2017","journal-title":"Prog. Chem. Org. Nat. Prod."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1038\/sj.bjp.0707460","article-title":"The orphan receptor GPR55 is a novel cannabinoid receptor","volume":"152","author":"Ryberg","year":"2007","journal-title":"Br. J. Pharmacol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/sj.bjp.0707399","article-title":"Meta-analysis of cannabinoid ligand binding affinity and receptor distribution: Interspecies differences","volume":"152","author":"McPartland","year":"2007","journal-title":"Br. J. Pharmacol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1159\/000494184","article-title":"Shufeng Jiedu Capsules Alleviate Lipopolysaccharide-Induced Acute Lung Inflammatory Injury via Activation of GPR18 by Verbenalin","volume":"50","author":"Yuan","year":"2018","journal-title":"Cell Physiol. Biochem."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"14216","DOI":"10.1021\/acs.jmedchem.0c00926","article-title":"Therapeutic Exploitation of GPR18: Beyond the Cannabinoids?","volume":"63","author":"Morales","year":"2020","journal-title":"J. Med. Chem."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/j.bbrc.2006.06.175","article-title":"Identification of N-arachidonylglycine as the endogenous ligand for orphan G-protein-coupled receptor GPR18","volume":"347","author":"Kohno","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"5922","DOI":"10.1021\/cr100396c","article-title":"Resolvins and protectins in inflammation resolution","volume":"111","author":"Serhan","year":"2011","journal-title":"Chem. Rev."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.ejmech.2018.05.050","article-title":"Structure-activity relationships of imidazothiazinones and analogs as antagonists of the cannabinoid-activated orphan G protein-coupled receptor GPR18","volume":"155","author":"Schoeder","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"822.9","DOI":"10.1096\/fasebj.27.1_supplement.822.9","article-title":"E. coli peritonitis initiates D-series Resolvin-metabolome","volume":"27","author":"Gao","year":"2013","journal-title":"FASEB J."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2597","DOI":"10.4049\/jimmunol.1201272","article-title":"Resolvin D1 and resolvin D2 govern local inflammatory tone in obese fat","volume":"189","author":"Dalli","year":"2012","journal-title":"J. Immunol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"233","DOI":"10.2174\/187152412802430156","article-title":"The Atypical Cannabinoid O-1602: Targets, Actions, and the Central Nervous System","volume":"12","author":"Ashton","year":"2012","journal-title":"Cent. Nerv. Syst. Agents Med. Chem."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1055\/a-1232-5758","article-title":"Verbena officinalis (Common Vervain)\u2014A Review on the Investigations of This Medicinally Important Plant Species","volume":"86","author":"Kubica","year":"2020","journal-title":"Planta Med."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Frankowska, M., Wydra, K., Suder, A., Zaniewska, M., Gawli\u0144ski, D., Miszkiel, J., Furga\u0142a-Wojas, A., Sa\u0142at, K., Filip, M., and M\u00fcller, C.E. (2023). Novel GPR18 Ligands in Rodent Pharmacological Tests: Effects on Mood, Pain, and Eating Disorders. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24109046"},{"key":"ref_33","unstructured":"Jagerovic, N., Lago, F.A., Morales, L.P., Abood, M.E., Brailoiu, E., Magalhaes, L.L., Zhao, P., Reggio, P.H., Hurst, D.P., and Chafi, N.S. (2021). Pyrazolylbenzene-1,3-diols for Diseases Associated with g Protein-Coupled Receptor 18 and in Combination with Transient Receptor Potential Vanilloid 1. (Application EP20382324), European Patent."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1124\/mol.63.3.699","article-title":"Selective Ligands and Cellular Effectors of a G Protein-Coupled Endothelial Cannabinoid Receptor","volume":"63","author":"Mo","year":"2003","journal-title":"Mol. Pharmacol."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"McHugh, D., Hu, S.S.J., Rimmerman, N., Juknat, A., Vogel, Z., Walker, J.M., and Bradshaw, H.B. (2010). N-arachidonoyl glycine, an abundant endogenous lipid, potently drives directed cellular migration through GPR18, the putative abnormal cannabidiol receptor. BMC Neurosci., 11.","DOI":"10.1186\/1471-2202-11-44"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1039\/C3MD00394A","article-title":"Bicyclic imidazole-4-one derivatives: A new class of antagonists for the orphan G protein-coupled receptors GPR18 and GPR55","volume":"5","author":"Rempel","year":"2014","journal-title":"Med. Chem. Commun."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"3458","DOI":"10.1016\/j.neuron.2022.10.020","article-title":"Microglia states and nomenclature: A field at its crossroads","volume":"110","author":"Paolicelli","year":"2022","journal-title":"Neuron"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"4622","DOI":"10.1523\/JNEUROSCI.2339-19.2020","article-title":"Similar Microglial Cell Densities across Brain Structures and Mammalian Species: Implications for Brain Tissue Function","volume":"40","author":"Santos","year":"2020","journal-title":"J. Neurosci."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/s41380-019-0609-8","article-title":"Microglial regional heterogeneity and its role in the brain","volume":"25","author":"Tan","year":"2020","journal-title":"Mol. Psychiatry"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"113699","DOI":"10.1016\/j.expneurol.2021.113699","article-title":"GPR18 drives FAAH inhibition-induced neuroprotection against HIV-1 Tat-induced neurodegeneration","volume":"341","author":"Hermes","year":"2021","journal-title":"Exp. Neurol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2379","DOI":"10.1007\/s10571-021-01114-2","article-title":"GPR18 Agonist Resolvin D2 Reduces Early Brain Injury in a Rat Model of Subarachnoid Hemorrhage by Multiple Protective Mechanisms","volume":"42","author":"Zhang","year":"2022","journal-title":"Cell. Mol. Neurobiol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.freeradbiomed.2022.06.231","article-title":"Resolution of inflammation is disturbed in acute ischemic stroke with diabetes mellitus and rescued by resolvin D2 treatment","volume":"188","author":"Tang","year":"2022","journal-title":"Free Radic. Biol. Med."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Miao, Z., Tang, X., Schultzberg, M., Zhao, Y., and Wang, X. (2021). Plasma Resolvin D2 to Leukotriene B(4) Ratio Is Reduced in Diabetic Patients with Ischemic Stroke and Related to Prognosis. Biomed. Res. Int., 2021.","DOI":"10.1155\/2021\/6657646"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s13041-018-0351-1","article-title":"Resolvin D2 protects against cerebral ischemia\/reperfusion injury in rats","volume":"11","author":"Zuo","year":"2018","journal-title":"Mol. Brain"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1159\/000435932","article-title":"Cytokines in Neuropathic Pain and Associated Depression","volume":"30","author":"Lees","year":"2015","journal-title":"Mod. Trends Pharmacopsychiatry"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"114573","DOI":"10.1016\/j.expneurol.2023.114573","article-title":"Resolvin D2 activates anti-inflammatory microglia via restoring autophagy flux and alleviate neuropathic pain following spinal cord injury in rats","volume":"370","author":"Yang","year":"2023","journal-title":"Exp. Neurol."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Pang, J., Xin, P., Kong, Y., Wang, Z., and Wang, X. (2023). Resolvin D2 Reduces Chronic Neuropathic Pain and Bone Cancer Pain via Spinal Inhibition of IL-17 Secretion, CXCL1 Release and Astrocyte Activation in Mice. Brain Sci., 13.","DOI":"10.3390\/brainsci13010152"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1002\/npr2.12198","article-title":"Resolvin D2 attenuates chronic pain-induced depression-like behavior in mice","volume":"41","author":"Suzuki","year":"2021","journal-title":"Neuropsychopharmacol. Rep."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1093\/ijnp\/pyx023","article-title":"Resolvin D1 and D2 Reverse Lipopolysaccharide-Induced Depression-Like Behaviors Through the mTORC1 Signaling Pathway","volume":"20","author":"Deyama","year":"2017","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.bbr.2017.06.010","article-title":"Rapid and sustained antidepressant effects of resolvin D1 and D2 in a chronic unpredictable stress model","volume":"332","author":"Ishikawa","year":"2017","journal-title":"Behav. Brain Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.bbrc.2015.03.109","article-title":"Resolvin D2 recovers neural injury by suppressing inflammatory mediators expression in lipopolysaccharide-induced Parkinson\u2019s disease rat model","volume":"460","author":"Tian","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1186\/s42269-021-00685-w","article-title":"The cellular biology of atherosclerosis with atherosclerotic lesion classification and biomarkers","volume":"45","author":"Melaku","year":"2021","journal-title":"Bull. Natl. Res. Cent."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/bs.apha.2022.12.005","article-title":"Insights into the role of the resolvin D2-GPR18 signaling axis in cardiovascular physiology and disease","volume":"97","author":"Spite","year":"2023","journal-title":"Adv. Pharmacol."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Bardin, M., Pawelzik, S.C., Lagrange, J., Mahdi, A., Arnardottir, H., Regnault, V., Feve, B., Lacolley, P., Michel, J.B., and Mercier, N. (2022). The resolvin D2\u2014GPR18 axis is expressed in human coronary atherosclerosis and transduces atheroprotection in apolipoprotein E deficient mice. Biochem. Pharmacol., 201.","DOI":"10.1016\/j.bcp.2022.115075"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1161\/CIRCULATIONAHA.116.021894","article-title":"Resolvin D2 Enhances Postischemic Revascularization While Resolving Inflammation","volume":"134","author":"Zhang","year":"2016","journal-title":"Circulation"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1161\/HYPERTENSIONAHA.122.19448","article-title":"Resolvin D2 Attenuates Cardiovascular Damage in Angiotensin II-Induced Hypertension","volume":"80","author":"Zaragoza","year":"2023","journal-title":"Hypertension"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1155\/2011\/953975","article-title":"Alternative targets within the endocannabinoid system for future treatment of gastrointestinal diseases","volume":"25","author":"Schicho","year":"2011","journal-title":"Can. J. Gastroenterol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1034648","DOI":"10.3389\/fimmu.2022.1034648","article-title":"CD4(+)-mediated colitis in mice is independent of the GPR183 and GPR18 pathways","volume":"13","author":"Dicker","year":"2022","journal-title":"Front. Immunol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"S182","DOI":"10.1093\/ecco-jcc\/jjab076.210","article-title":"P081 Resolvin D2 attenuates colonic inflammation of Crohn\u2019s disease patients","volume":"15","author":"Pascoal","year":"2021","journal-title":"J. Crohn\u2019s Colitis"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s12974-016-0777-2","article-title":"Resolvin RvD2 reduces hypothalamic inflammation and rescues mice from diet-induced obesity","volume":"14","author":"Pascoal","year":"2017","journal-title":"J. Neuroinflamm."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1136\/gutjnl-2020-321530","article-title":"Effect of resolvins on sensitisation of TRPV1 and visceral hypersensitivity in IBS","volume":"70","author":"Perna","year":"2021","journal-title":"Gut"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"345","DOI":"10.2147\/JIR.S174982","article-title":"The role of inflammation in irritable bowel syndrome (IBS)","volume":"11","author":"Ng","year":"2018","journal-title":"J. Inflamm. Res."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1046\/j.1365-2982.2000.00221.x","article-title":"Increased mast cells in the irritable bowel syndrome","volume":"12","author":"Clayton","year":"2000","journal-title":"Neurogastroenterol. Motil."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.3892\/etm.2021.10656","article-title":"Resolvin D2 suppresses NLRP3 inflammasome by promoting autophagy in macrophages","volume":"22","author":"Cao","year":"2021","journal-title":"Exp. Ther. Med."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1011944","DOI":"10.3389\/fimmu.2022.1011944","article-title":"Resolvin D2 induces anti-microbial mechanisms in a model of infectious peritonitis and secondary lung infection","volume":"13","author":"Sundarasivarao","year":"2022","journal-title":"Front. Immunol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1038\/nature08541","article-title":"Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis","volume":"461","author":"Spite","year":"2009","journal-title":"Nature"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"307","DOI":"10.3389\/fimmu.2019.00307","article-title":"Resolvin D2 Induces Resolution of Periapical Inflammation and Promotes Healing of Periapical Lesions in Rat Periapical Periodontitis","volume":"10","author":"Siddiqui","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.3389\/fimmu.2020.01307","article-title":"Distinct Profiles of Specialized Pro-resolving Lipid Mediators and Corresponding Receptor Gene Expression in Periodontal Inflammation","volume":"11","author":"Ferguson","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"m4457","DOI":"10.1136\/bmj.m4457","article-title":"Covid-19: What now for remdesivir?","volume":"371","author":"Hsu","year":"2020","journal-title":"BMJ"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"747450","DOI":"10.3389\/fphar.2021.747450","article-title":"Eicosanoid Metabolomic Profile of Remdesivir Treatment in Rat Plasma by High-Performance Liquid Chromatography Mass Spectrometry","volume":"12","author":"Du","year":"2021","journal-title":"Front. Pharmacol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"e21441","DOI":"10.1096\/fj.202001952R","article-title":"Resolvin D1 and D2 reduce SARS-CoV-2-induced inflammatory responses in cystic fibrosis macrophages","volume":"35","author":"Recchiuti","year":"2021","journal-title":"FASEB J."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1134661","DOI":"10.3389\/fimmu.2023.1134661","article-title":"NF-\u03baB in monocytes and macrophages\u2014An inflammatory master regulator in multitalented immune cells","volume":"14","author":"Mussbacher","year":"2023","journal-title":"Front. Immunol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"6264","DOI":"10.1038\/s41467-021-26516-0","article-title":"Resolvin-D2 targets myogenic cells and improves muscle regeneration in Duchenne muscular dystrophy","volume":"12","author":"Dort","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"3669","DOI":"10.4049\/jimmunol.1103180","article-title":"IL-10 triggers changes in macrophage phenotype that promote muscle growth and regeneration","volume":"189","author":"Deng","year":"2012","journal-title":"J. Immunol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1111\/all.15920","article-title":"Resolvin D2 regulates type 2 inflammatory responses and promotes resolution of mouse allergic inflammation","volume":"79","author":"Peh","year":"2023","journal-title":"Allergy"},{"key":"ref_76","first-page":"1","article-title":"Inflammation and the Microcirculation","volume":"2","author":"Granger","year":"2010","journal-title":"Colloq. Ser. Integr. Syst. Physiol. Mol. Funct."},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Gao, J., Su, Y., and Wang, Z. (2023). Lung Inflammation Resolution by RvD1 and RvD2 in a Receptor-Dependent Manner. Pharmaceutics, 15.","DOI":"10.3390\/pharmaceutics15051527"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"40","DOI":"10.4103\/jpi.jpi_11_21","article-title":"QuPath Digital Immunohistochemical Analysis of Placental Tissue","volume":"12","author":"Hein","year":"2021","journal-title":"J. Pathol. Inf."},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Ulu, A., Sahoo, P.K., Yuil-Valdes, A.G., Mukherjee, M., Van Ormer, M., Muthuraj, P.G., Thompson, M., Anderson Berry, A., Hanson, C.K., and Natarajan, S.K. (2019). Omega-3 Fatty Acid-Derived Resolvin D2 Regulates Human Placental Vascular Smooth Muscle and Extravillous Trophoblast Activities. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20184402"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1161\/CIRCULATIONAHA.122.061934","article-title":"Placental Inflammation Leads to Abnormal Embryonic Heart Development","volume":"147","author":"Ward","year":"2023","journal-title":"Circulation"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"531543","DOI":"10.3389\/fimmu.2020.531543","article-title":"Maternal-Fetal Inflammation in the Placenta and the Developmental Origins of Health and Disease","volume":"11","author":"Goldstein","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.bbrc.2012.01.027","article-title":"N-arachidonoyl glycine induces macrophage apoptosis via GPR18","volume":"418","author":"Takenouchi","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"13079","DOI":"10.1074\/jbc.M113.536953","article-title":"The endocannabinoid\/endovanilloid N-arachidonoyl dopamine (NADA) and synthetic cannabinoid WIN55,212-2 abate the inflammatory activation of human endothelial cells","volume":"289","author":"Wilhelmsen","year":"2014","journal-title":"J. Biol. Chem."},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Koz\u0142owska, H., Malinowska, B., Baranowska-Kuczko, M., Kusaczuk, M., Nesterowicz, M., Koz\u0142owski, M., M\u00fcller, C.E., Kie\u0107-Kononowicz, K., and Schlicker, E. (2022). GPR18-Mediated Relaxation of Human Isolated Pulmonary Arteries. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23031427"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"e14003","DOI":"10.1111\/nmo.14003","article-title":"Novel selective agonist of GPR18, PSB-KK-1415 exerts potent anti-inflammatory and anti-nociceptive activities in animal models of intestinal inflammation and inflammatory pain","volume":"33","author":"Fabisiak","year":"2021","journal-title":"Neurogastroenterol. Motil."},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Dort, J., Orfi, Z., Fiscaletti, M., Campeau, P.M., and Dumont, N.A. (2023). Gpr18 agonist dampens inflammation, enhances myogenesis, and restores muscle function in models of Duchenne muscular dystrophy. Front. Cell Dev. Biol., 11.","DOI":"10.3389\/fcell.2023.1187253"},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Kota\u0144ska, M., Kubacka, M., Bednarski, M., Nicosia, N., Szafarz, M., Jawie\u0144, W., M\u00fcller, C.E., and Kie\u0107-Kononowicz, K. (2021). The GPR18 Agonist PSB-KD-107 Exerts Endothelium-Dependent Vasorelaxant Effects. Pharmaceuticals, 14.","DOI":"10.3390\/ph14080799"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1530\/EC-18-0535","article-title":"Atypical cannabinoid ligands O-1602 and O-1918 administered chronically in diet-induced obesity","volume":"8","author":"Simcocks","year":"2019","journal-title":"Endocr. Connect."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Simcocks, A.C., O\u2019Keefe, L., Jenkin, K.A., Cornall, L.M., Grinfeld, E., Mathai, M.L., Hryciw, D.H., and McAinch, A.J. (2020). The Role of Atypical Cannabinoid Ligands O-1602 and O-1918 on Skeletal Muscle Homeostasis with a Focus on Obesity. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21165922"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"239","DOI":"10.2174\/1874467212666190215112036","article-title":"New Insights in Cannabinoid Receptor Structure and Signaling","volume":"12","author":"Ye","year":"2019","journal-title":"Curr. Mol. Pharmacol."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/29\/6\/1258\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:12:29Z","timestamp":1760105549000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/29\/6\/1258"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,12]]},"references-count":90,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2024,3]]}},"alternative-id":["molecules29061258"],"URL":"https:\/\/doi.org\/10.3390\/molecules29061258","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,12]]}}}