{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T16:50:06Z","timestamp":1780332606435,"version":"3.54.1"},"reference-count":36,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2024,3,21]],"date-time":"2024-03-21T00:00:00Z","timestamp":1710979200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Liaoning Education Department","award":["JYTZD2023118"],"award-info":[{"award-number":["JYTZD2023118"]}]},{"name":"Liaoning Education Department","award":["LJKZ0645"],"award-info":[{"award-number":["LJKZ0645"]}]},{"name":"Liaoning Education Department","award":["LJKMZ20221045"],"award-info":[{"award-number":["LJKMZ20221045"]}]},{"name":"Liaoning Education Department","award":["32172454"],"award-info":[{"award-number":["32172454"]}]},{"name":"Liaoning Provincial Department of Education","award":["JYTZD2023118"],"award-info":[{"award-number":["JYTZD2023118"]}]},{"name":"Liaoning Provincial Department of Education","award":["LJKZ0645"],"award-info":[{"award-number":["LJKZ0645"]}]},{"name":"Liaoning Provincial Department of Education","award":["LJKMZ20221045"],"award-info":[{"award-number":["LJKMZ20221045"]}]},{"name":"Liaoning Provincial Department of Education","award":["32172454"],"award-info":[{"award-number":["32172454"]}]},{"name":"National Natural Science Foundation of China","award":["JYTZD2023118"],"award-info":[{"award-number":["JYTZD2023118"]}]},{"name":"National Natural Science Foundation of China","award":["LJKZ0645"],"award-info":[{"award-number":["LJKZ0645"]}]},{"name":"National Natural Science Foundation of China","award":["LJKMZ20221045"],"award-info":[{"award-number":["LJKMZ20221045"]}]},{"name":"National Natural Science Foundation of China","award":["32172454"],"award-info":[{"award-number":["32172454"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>SYAUP-491 is a novel alkyl sulfonamide. In this study, in vivo and in vitro tests were performed along with a proteomic analysis to determine the effects and underlying mechanisms of the antibacterial activity of SYAUP-491 against the causative agent of bacterial leaf blight in rice. The antibacterial test results suggested that SYAUP-491 exhibited significant activities against Xanthomonas oryzae pv. oryzae (Xoo) in vitro and in vivo. The minimal EC50 values reached 6.96 \u03bcg\/mL and the curative activity reached 74.1%. Detailed studies demonstrated that SYAUP-491 altered membrane permeability and caused morphological changes. Based on proteomics results, SYAUP-491 might inhibit bacterial protein synthesis. SYAUP-491 may disrupt and alter cell membrane permeability and could further act on ribosomes in the bacterial body. Given the above results, SYAUP-491 could serve as a new lead compound in the research of antibacterial control of plant pathogenic bacterial disease.<\/jats:p>","DOI":"10.3390\/molecules29061413","type":"journal-article","created":{"date-parts":[[2024,3,21]],"date-time":"2024-03-21T11:37:22Z","timestamp":1711021042000},"page":"1413","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Antibacterial Activities and Underlying Mechanisms of the Compound SYAUP-491 against Xanthomonas oryzae pv. oryzae"],"prefix":"10.3390","volume":"29","author":[{"given":"Lina","family":"Li","sequence":"first","affiliation":[{"name":"College of Plant Protection, Shenyang Agricultural University, No. 120 Dongling Road, Shenhe District, Shenyang 110866, China"},{"name":"Institute of Agricultural Quality Standards and Testing Technology, Liaoning Academy of Agricultural Sciences, No. 84 Dongling Road, Shenhe District, Shenyang 110866, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxin","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Plant Protection, Shenyang Agricultural University, No. 120 Dongling Road, Shenhe District, Shenyang 110866, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Plant Protection, Shenyang Agricultural University, No. 120 Dongling Road, Shenhe District, Shenyang 110866, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Plant Protection, Shenyang Agricultural University, No. 120 Dongling Road, Shenhe District, Shenyang 110866, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinchen","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Plant Protection, Shenyang Agricultural University, No. 120 Dongling Road, Shenhe District, Shenyang 110866, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengnan","family":"An","sequence":"additional","affiliation":[{"name":"College of Plant Protection, Shenyang Agricultural University, No. 120 Dongling Road, Shenhe District, Shenyang 110866, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Yu","sequence":"additional","affiliation":[{"name":"College of Plant Protection, Shenyang Agricultural University, No. 120 Dongling Road, Shenhe District, Shenyang 110866, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanhua","family":"Wu","sequence":"additional","affiliation":[{"name":"College of Plant Protection, Shenyang Agricultural University, No. 120 Dongling Road, Shenhe District, Shenyang 110866, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinghai","family":"Li","sequence":"additional","affiliation":[{"name":"College of Plant Protection, Shenyang Agricultural University, No. 120 Dongling Road, Shenhe District, Shenyang 110866, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianzhong","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Agricultural Quality Standards and Testing Technology, Liaoning Academy of Agricultural Sciences, No. 84 Dongling Road, Shenhe District, Shenyang 110866, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,3,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1146\/annurev-phyto-102313-045926","article-title":"Novel insights into rice innate immunity against bacterial and fungal pathogens","volume":"52","author":"Liu","year":"2014","journal-title":"Annu. 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