{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T06:19:03Z","timestamp":1792131543875,"version":"4.4.0"},"reference-count":244,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2024,3,31]],"date-time":"2024-03-31T00:00:00Z","timestamp":1711843200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Natural Science Foundation Project of the Anhui Educational Committee","award":["KJ2020A0791"],"award-info":[{"award-number":["KJ2020A0791"]}]},{"name":"Natural Science Foundation Project of the Anhui Educational Committee","award":["zdxk202104"],"award-info":[{"award-number":["zdxk202104"]}]},{"name":"Key Subject of Anhui Xinhua University","award":["KJ2020A0791"],"award-info":[{"award-number":["KJ2020A0791"]}]},{"name":"Key Subject of Anhui Xinhua University","award":["zdxk202104"],"award-info":[{"award-number":["zdxk202104"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>The formation of new blood vessels, known as angiogenesis, significantly impacts the development of multiple types of cancer. Consequently, researchers have focused on targeting this process to prevent and treat numerous disorders. However, most existing anti-angiogenic treatments rely on synthetic compounds and humanized monoclonal antibodies, often expensive or toxic, restricting patient access to these therapies. Hence, the pursuit of discovering new, affordable, less toxic, and efficient anti-angiogenic compounds is imperative. Numerous studies propose that natural plant-derived products exhibit these sought-after characteristics. The objective of this review is to delve into the anti-angiogenic properties exhibited by naturally derived flavonoids from plants, along with their underlying molecular mechanisms of action. Additionally, we summarize the structure, classification, and the relationship between flavonoids with their signaling pathways in plants as anti-angiogenic agents, including main HIF-1\u03b1\/VEGF\/VEGFR2\/PI3K\/AKT, Wnt\/\u03b2-catenin, JNK1\/STAT3, and MAPK\/AP-1 pathways. Nonetheless, further research and innovative approaches are required to enhance their bioavailability for clinical application.<\/jats:p>","DOI":"10.3390\/molecules29071570","type":"journal-article","created":{"date-parts":[[2024,3,31]],"date-time":"2024-03-31T13:32:56Z","timestamp":1711891976000},"page":"1570","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":62,"title":["Flavonoids with Anti-Angiogenesis Function in Cancer"],"prefix":"10.3390","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8348-1860","authenticated-orcid":false,"given":"Qiang","family":"Wei","sequence":"first","affiliation":[{"name":"School of Medicine, Anhui Xinhua University, 555 Wangjiang West Road, Hefei 230088, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-han","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Medicine, Anhui Xinhua University, 555 Wangjiang West Road, Hefei 230088, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,3,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2174\/2215083808666220321150234","article-title":"An overview of flavonoids: A diverse group of bioactive phytoconstituents","volume":"9","author":"Arora","year":"2023","journal-title":"Curr. 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