{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T16:02:17Z","timestamp":1769443337759,"version":"3.49.0"},"reference-count":89,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2024,4,7]],"date-time":"2024-04-07T00:00:00Z","timestamp":1712448000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2022QC087"],"award-info":[{"award-number":["ZR2022QC087"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Curcumin (CCM) is a polyphenol compound extracted from the turmeric rhizome. It has various biological activities, including antibacterial, anti-inflammatory, anti-cancer, and antioxidant. Due to its diverse activities, it is often used by researchers to study the therapeutic effects on various diseases. However, its poor solubility leads to poor bioavailability, and it is necessary to increase the water solubility with the help of carriers to improve the therapeutic effect. Gastrointestinal disease is a major global health problem that continues to affect human health. In this review, we have summarized the possible mechanism and therapeutic effect of CCM in various gastrointestinal diseases, and the improvement in the curative effect of CCM with nanopreparation. Finally, we concluded that there have been many clinical trials of CCM in combination with other drugs for the treatment of gastrointestinal disease, but so far, few have used CCM nanomaterials for treatment. Although in vitro and preclinical experiments have shown that nanopreparations can improve the efficacy of CCM, there are still insufficient studies on the safety of carriers.<\/jats:p>","DOI":"10.3390\/molecules29071659","type":"journal-article","created":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T03:11:33Z","timestamp":1712545893000},"page":"1659","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Advancing Gastrointestinal Health: Curcumin\u2019s Efficacy and Nanopreparations"],"prefix":"10.3390","volume":"29","author":[{"given":"Jialin","family":"Ji","sequence":"first","affiliation":[{"name":"School of Clinical Medicine, Shandong Second Medical University, Weifang 261053, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaojie","family":"Ma","sequence":"additional","affiliation":[{"name":"School of Humanities and Medicine, Shandong Second Medical University, Weifang 261053, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingshuai","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Life Science and Technology, Shandong Second Medical University, Weifang 261053, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3697","DOI":"10.21037\/apm-21-1464","article-title":"Prevalence of chronic atrophic gastritis worldwide from 2010 to 2020: An updated systematic review and meta-analysis","volume":"11","author":"Yin","year":"2022","journal-title":"Ann. 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