{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T23:40:43Z","timestamp":1771630843771,"version":"3.50.1"},"reference-count":41,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2024,4,13]],"date-time":"2024-04-13T00:00:00Z","timestamp":1712966400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Natural Science Foundation of Jilin Provincial Department of Science and Technology","award":["20210101033JC"],"award-info":[{"award-number":["20210101033JC"]}]},{"name":"Natural Science Foundation of Jilin Provincial Department of Science and Technology","award":["202213706002"],"award-info":[{"award-number":["202213706002"]}]},{"name":"National College Student Innovation and Entrepreneurship Program","award":["20210101033JC"],"award-info":[{"award-number":["20210101033JC"]}]},{"name":"National College Student Innovation and Entrepreneurship Program","award":["202213706002"],"award-info":[{"award-number":["202213706002"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>The aim of this study was to develop cholic-acid-stabilized itraconazole nanosuspensions (ITZ-Nanos) with the objective of enhancing drug dissolution and oral absorption. A laboratory-scale microprecipitation\u2013high-pressure homogenization method was employed for the preparation of the ITZ-Nanos, while dynamic light scattering, transmission electron microscope analysis, X-ray diffraction, differential scanning calorimetry, and high-performance liquid chromatography analysis were utilized to evaluate their physicochemical properties. The absorption and bioavailability of the ITZ-Nanos were assessed using Caco-2 cells and rats, with Sporanox\u00ae pellets as a comparison. Prior to lyophilization, the particle size of the ITZ-Nanos measured approximately 225.7 nm. Both X-ray diffraction and differential scanning calorimetry confirmed that the ITZ remained crystalline within the nanocrystals. Compared to the pellets, the ITZ-Nanos exhibited significantly higher levels of supersaturation dissolution and demonstrated enhanced drug uptake by the Caco-2 cells. The AUC(0\u2013t) value for the ITZ-Nanos in rats was 1.33-fold higher than that observed for the pellets. These findings suggest that cholic acid holds promise as a stabilizer for ITZ nanocrystals, as well as potentially other nanocrystals.<\/jats:p>","DOI":"10.3390\/molecules29081769","type":"journal-article","created":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T03:56:13Z","timestamp":1713153373000},"page":"1769","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Increased Dissolution and Oral Absorption of Itraconazole by Nanocrystals with an Endogenous Small-Molecule Surfactant as a Stabilizer"],"prefix":"10.3390","volume":"29","author":[{"given":"Sheng","family":"Chang","sequence":"first","affiliation":[{"name":"College of Pharmacy, Jilin Medical University, Jilin 132013, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiang","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Antiviral Drugs, School of Pharmacy, Henan University, Kaifeng 475004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiahuan","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Jilin Medical University, Jilin 132013, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Yin","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Antiviral Drugs, School of Pharmacy, Henan University, Kaifeng 475004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jihong","family":"Han","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Bioengineering, Keele University, Kiel ST5 5BG, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lanlan","family":"Zong","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Antiviral Drugs, School of Pharmacy, Henan University, Kaifeng 475004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9359-9651","authenticated-orcid":false,"given":"Xiaohui","family":"Pu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Antiviral Drugs, School of Pharmacy, Henan University, Kaifeng 475004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.tim.2021.12.013","article-title":"Emergence and evolution of virulence in human pathogenic fungi","volume":"30","author":"Hube","year":"2022","journal-title":"Trends. 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