{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T15:09:17Z","timestamp":1793286557743,"version":"4.5.0"},"reference-count":32,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T00:00:00Z","timestamp":1713916800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Canon Medical Systems Corporation","award":["JP24K00912"],"award-info":[{"award-number":["JP24K00912"]}]},{"name":"Canon Medical Systems Corporation","award":["23K13652"],"award-info":[{"award-number":["23K13652"]}]},{"name":"JSPS KAKENHI","award":["JP24K00912"],"award-info":[{"award-number":["JP24K00912"]}]},{"name":"JSPS KAKENHI","award":["23K13652"],"award-info":[{"award-number":["23K13652"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Microdroplet-based fluidic systems have the advantages of small size, short diffusion time, and no cross-contamination; consequently, droplets often provide a fast and precise reaction environment as well as an analytical environment for individual molecules. In order to handle diverse reactions, we developed a method to create organic single-micron droplets (S-MDs) smaller than 5 \u03bcm in diameter dispersed in silicone oil without surfactant. The S-MD generation microflow device consists of a mother droplet (MoD) generator and a tapered separation channel featuring multiple side channels. The tapered channel enhanced the shear forces to form tails from the MoDs, causing them to break up. Surface treatment with the fluoropolymer CYTOP protected PDMS fluid devices from organic fluids. The tailing separation of methanol droplets was accomplished without the use of surfactants. The generation of tiny organic droplets may offer new insights into chemical separation and help study the scaling effects of various chemical reactions.<\/jats:p>","DOI":"10.3390\/molecules29091949","type":"journal-article","created":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T10:18:36Z","timestamp":1713953916000},"page":"1949","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Efficient Separation of Methanol Single-Micron Droplets by Tailing Phenomenon Using a PDMS Microfluidic Device"],"prefix":"10.3390","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1900-4848","authenticated-orcid":false,"given":"Daiki","family":"Tanaka","sequence":"first","affiliation":[{"name":"Department of Electronic and Physical Systems, School of Fundamental Science and Engineering, Waseda University, Tokyo 145-0065, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengqi","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Electronic and Physical Systems, School of Fundamental Science and Engineering, Waseda University, Tokyo 145-0065, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1221-2874","authenticated-orcid":false,"given":"Masahiro","family":"Furuya","sequence":"additional","affiliation":[{"name":"Cooperative Major in Nuclear Energy, Waseda University, Tokyo 169-8555, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Cooperative Major in Nuclear Energy, Waseda University, Tokyo 169-8555, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Fujita","sequence":"additional","affiliation":[{"name":"Canon Medical Systems Corporation, Otawara 324-8550, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4410-4912","authenticated-orcid":false,"given":"Takashiro","family":"Akitsu","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science, Tokyo University of Science, Tokyo 162-0825, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsushi","family":"Sekiguchi","sequence":"additional","affiliation":[{"name":"Research Organization for Nano & Life Innovation, Waseda University, Tokyo 162-0041, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuichi","family":"Shoji","sequence":"additional","affiliation":[{"name":"Department of Electronic and Physical Systems, School of Fundamental Science and Engineering, Waseda University, Tokyo 145-0065, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1093\/ajcp\/28.3_ts.311","article-title":"An automatic method for colorimetric analysis","volume":"27","author":"Skeggs","year":"1957","journal-title":"Am. 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