{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T06:59:18Z","timestamp":1776322758795,"version":"3.50.1"},"reference-count":53,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2024,4,26]],"date-time":"2024-04-26T00:00:00Z","timestamp":1714089600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Yunnan Science and Technology Talents support plan","award":["YNWR-QNBJ-2018-083"],"award-info":[{"award-number":["YNWR-QNBJ-2018-083"]}]},{"name":"Yunnan Science and Technology Talents support plan","award":["202301BD070001-029"],"award-info":[{"award-number":["202301BD070001-029"]}]},{"name":"Basic Research Program of Yunnan Province","award":["YNWR-QNBJ-2018-083"],"award-info":[{"award-number":["YNWR-QNBJ-2018-083"]}]},{"name":"Basic Research Program of Yunnan Province","award":["202301BD070001-029"],"award-info":[{"award-number":["202301BD070001-029"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Gallic acid (GA) is a type of polyphenolic compound that can be found in a range of fruits, vegetables, and tea. Although it has been confirmed it improves non-alcoholic fatty liver disease (NAFLD), it is still unknown whether GA can improve the occurrence of NAFLD by increasing the low-density lipoprotein receptor (LDLR) accumulation and alleviating cholesterol metabolism disorders. Therefore, the present study explored the effect of GA on LDLR and its mechanism of action. The findings indicated that the increase in LDLR accumulation in HepG2 cells induced by GA was associated with the stimulation of the epidermal growth factor receptor\u2013extracellular regulated protein kinase (EGFR-ERK1\/2) signaling pathway. When the pathway was inhibited by EGFR mab cetuximab, it was observed that the activation of the EGFR-ERK1\/2 signaling pathway induced by GA was also blocked. At the same time, the accumulation of LDLR protein and the uptake of LDL were also suppressed. Additionally, GA can also promote the accumulation of forkhead box O3 (FOXO3) and suppress the accumulation of hepatocyte nuclear factor-1\u03b1 (HNF1\u03b1), leading to the inhibition of proprotein convertase subtilisin\/kexin 9 (PCSK9) mRNA expression and protein accumulation. This ultimately results in increased LDLR protein accumulation and enhanced uptake of LDL in cells. In summary, the present study revealed the potential mechanism of GA\u2019s role in ameliorating NAFLD, with a view of providing a theoretical basis for the dietary supplementation of GA.<\/jats:p>","DOI":"10.3390\/molecules29091999","type":"journal-article","created":{"date-parts":[[2024,4,26]],"date-time":"2024-04-26T08:18:27Z","timestamp":1714119507000},"page":"1999","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Gallic Acid Can Promote Low-Density Lipoprotein Uptake in HepG2 Cells via Increasing Low-Density Lipoprotein Receptor Accumulation"],"prefix":"10.3390","volume":"29","author":[{"given":"Dongying","family":"Zhang","sequence":"first","affiliation":[{"name":"College of Science, Yunnan Agricultural University, Kunming 650201, China"},{"name":"Key Laboratory of Pu-er Tea Science, Ministry of Education, Yunnan Agricultural University, Kunming 650201, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qixing","family":"Zhou","sequence":"additional","affiliation":[{"name":"Key Laboratory of Pu-er Tea Science, Ministry of Education, Yunnan Agricultural University, Kunming 650201, China"},{"name":"College of Food Science and Technology, Yunnan Agricultural University, Kunming 650201, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangxuan","family":"Yang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Pu-er Tea Science, Ministry of Education, Yunnan Agricultural University, Kunming 650201, China"},{"name":"College of Food Science and Technology, Yunnan Agricultural University, Kunming 650201, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Pu-er Tea Science, Ministry of Education, Yunnan Agricultural University, Kunming 650201, China"},{"name":"College of Food Science and Technology, Yunnan Agricultural University, Kunming 650201, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongxue","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Pu-er Tea Science, Ministry of Education, Yunnan Agricultural University, Kunming 650201, China"},{"name":"College of Food Science and Technology, Yunnan Agricultural University, Kunming 650201, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dandan","family":"Hu","sequence":"additional","affiliation":[{"name":"College of Science, Yunnan Agricultural University, Kunming 650201, China"},{"name":"Key Laboratory of Pu-er Tea Science, Ministry of Education, Yunnan Agricultural University, Kunming 650201, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yewei","family":"Huang","sequence":"additional","affiliation":[{"name":"College of Science, Yunnan Agricultural University, Kunming 650201, China"},{"name":"Key Laboratory of Pu-er Tea Science, Ministry of Education, Yunnan Agricultural University, Kunming 650201, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Sheng","sequence":"additional","affiliation":[{"name":"College of Food Science and Technology, Yunnan Agricultural University, Kunming 650201, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuanjun","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica and Yunnan Key Laboratory of Southern Medicinal Resource, Yunnan University of Chinese Medicine, Kunming 650500, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e141513","DOI":"10.1172\/JCI141513","article-title":"Neutrophil-to-hepatocyte communication via LDLR-dependent miR-223-enriched extracellular vesicle transfer ameliorates nonalcoholic steatohepatitis","volume":"131","author":"He","year":"2021","journal-title":"J. Clin. Investig."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"101109","DOI":"10.1016\/j.plipres.2021.101109","article-title":"Hepatic cholesterol transport and its role in non-alcoholic fatty liver disease and atherosclerosis","volume":"83","author":"Li","year":"2021","journal-title":"Prog. Lipid Res."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Pouwels, S., Sakran, N., Graham, Y., Leal, A., Pintar, T., Yang, W., Kassir, R., Singhal, R., Mahawar, K., and Ramnarain, D. (2022). Non-alcoholic fatty liver disease (NAFLD): A review of pathophysiology, clinical management and effects of weight loss. BMC Endocr. Disord., 22.","DOI":"10.1186\/s12902-022-00980-1"},{"key":"ref_4","first-page":"1215","article-title":"Research progress in the regulation of cholesterol metabolism and its involvement in the occurrence and development of liver cancer","volume":"28","author":"Li","year":"2021","journal-title":"Chin. J. Cancer Biother."},{"key":"ref_5","first-page":"292","article-title":"Regulation Mechanism of Intracellular Cholesterol Level","volume":"49","author":"Zhang","year":"2022","journal-title":"Prog. Biochem. BioPhys."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Vourakis, M., Mayer, G., and Rousseau, G. (2021). The Role of Gut Microbiota on Cholesterol Metabolism in Atherosclerosis. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22158074"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"5728","DOI":"10.18632\/oncotarget.6799","article-title":"Increased levels of low-density lipoprotein cholesterol within the normal range as a risk factor for nonalcoholic fatty liver disease","volume":"7","author":"Sun","year":"2016","journal-title":"Oncotarget"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1126\/science.3513311","article-title":"A receptor-mediated pathway for cholesterol homeostasis","volume":"232","author":"Brown","year":"1986","journal-title":"Science"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.cell.2005.12.022","article-title":"Protein sensors for membrane sterols","volume":"124","author":"Goldstein","year":"2006","journal-title":"Cell"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1038\/nm1135","article-title":"Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins","volume":"10","author":"Kong","year":"2004","journal-title":"Nat. Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S0022-2275(20)37252-7","article-title":"Modulation of LDL receptor mRNA stability by phorbol esters in human liver cell culture models","volume":"38","author":"Wilson","year":"1997","journal-title":"J. Lipid Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1097\/MOL.0000000000000114","article-title":"PCSK9 and LDLR degradation: Regulatory mechanisms in circulation and in cells","volume":"25","author":"Lagace","year":"2014","journal-title":"Curr. Opin. Lipidol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/S0022-2275(20)33870-0","article-title":"Stabilization and cytoskeletal-association of LDL receptor mRNA are mediated by distinct domains in its 3\u2032 untranslated region","volume":"39","author":"Wilson","year":"1998","journal-title":"J. Lipid Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"128","DOI":"10.21037\/tlcr-20-812","article-title":"Cholesterol synthesis disruption combined with a molecule-targeted drug is a promising metabolic therapy for EGFR mutant non-small cell lung cancer","volume":"10","author":"Luo","year":"2021","journal-title":"Transl. Cancer Res."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1002\/jcb.27102","article-title":"Berberrubine and its analog, hydroxypropyl-berberrubine, regulate LDLR and PCSK9 expression via the ERK signal pathway to exert cholesterol-lowering effects in human hepatoma HepG2 cells","volume":"120","author":"Cao","year":"2019","journal-title":"J. Cell. Biochem."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.bbagrm.2017.11.010","article-title":"5-Azacytidine engages an IRE1alpha-EGFR-ERK1\/2 signaling pathway that stabilizes the LDL receptor mRNA","volume":"1861","author":"Mnasri","year":"2018","journal-title":"Biochim. Biophys. Acta Gene Regul. Mech."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Zhu, X., Bian, H., and Gao, X. (2016). The Potential Mechanisms of Berberine in the Treatment of Nonalcoholic Fatty Liver Disease. Molecules, 21.","DOI":"10.3390\/molecules21101336"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"3269","DOI":"10.1039\/D2FO02701A","article-title":"Caffeine can alleviate non-alcoholic fatty liver disease by augmenting LDLR expression via targeting EGFR","volume":"14","author":"Huang","year":"2023","journal-title":"Food Funct."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1161\/CIRCULATIONAHA.115.016080","article-title":"Proprotein convertase subtilisin\/kexin type 9 inhibition: A new therapeutic mechanism for reducing cardiovascular disease risk","volume":"132","author":"Bergeron","year":"2015","journal-title":"Circulation"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.drudis.2017.01.006","article-title":"PCSK9 and diabetes: Is there a link?","volume":"22","author":"Momtazi","year":"2017","journal-title":"Drug Discov. Today"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1074\/jbc.M808363200","article-title":"Structural and biochemical characterization of the wild type PCSK9-EGF(AB) complex and natural familial hypercholesterolemia mutants","volume":"284","author":"Bottomley","year":"2009","journal-title":"J. Biol. Chem."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1038\/embor.2011.205","article-title":"Mechanistic implications for LDL receptor degradation from the PCSK9\/LDLR structure at neutral pH","volume":"12","author":"Bottomley","year":"2011","journal-title":"EMBO Rep."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"28885","DOI":"10.1074\/jbc.M109.052407","article-title":"Hepatocyte nuclear factor 1alpha plays a critical role in PCSK9 gene transcription and regulation by the natural hypocholesterolemic compound berberine","volume":"284","author":"Li","year":"2009","journal-title":"J. Biol. Chem."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"29252","DOI":"10.1074\/jbc.M113.481473","article-title":"FoxO3 transcription factor and Sirt6 deacetylase regulate low density lipoprotein (LDL)-cholesterol homeostasis via control of the proprotein convertase subtilisin\/kexin type 9 (Pcsk9) gene expression","volume":"288","author":"Tao","year":"2013","journal-title":"J. Biol. Chem."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1743-7075-10-4","article-title":"Plasma PCSK9 concentrations during an oral fat load and after short term high-fat, high-fat high-protein and high-fructose diets","volume":"10","author":"Cariou","year":"2013","journal-title":"Nutr. Metab."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"112576","DOI":"10.1016\/j.fct.2021.112576","article-title":"Gallic acid for cancer therapy: Molecular mechanisms and boosting efficacy by nanoscopical delivery","volume":"157","author":"Ashrafizadeh","year":"2021","journal-title":"Food Chem. Toxicol."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Chao, J., Huo, T.I., Cheng, H.Y., Tsai, J.C., Liao, J.W., Lee, M.S., Qin, X.M., Hsieh, M.T., Pao, L.H., and Peng, W.H. (2014). Gallic acid ameliorated impaired glucose and lipid homeostasis in high fat diet-induced NAFLD mice. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0096969"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Kongpichitchoke, T., Chiu, M.T., Huang, T.C., and Hsu, J.L. (2016). Gallic Acid Content in Taiwanese Teas at Different Degrees of Fermentation and Its Antioxidant Activity by Inhibiting PKCdelta Activation: In Vitro and in Silico Studies. Molecules, 21.","DOI":"10.3390\/molecules21101346"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.ejphar.2014.10.044","article-title":"Gallic acid attenuates high-fat diet fed-streptozotocin-induced insulin resistance via partial agonism of PPARgamma in experimental type 2 diabetic rats and enhances glucose uptake through translocation and activation of GLUT4 in PI3K\/p-Akt signaling pathway","volume":"745","author":"Gandhi","year":"2014","journal-title":"Eur. J. Pharmacol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.ejphar.2010.08.059","article-title":"Antihyperglycaemic, antilipid peroxidative and antioxidant effects of gallic acid on streptozotocin induced diabetic Wistar rats","volume":"650","author":"Punithavathi","year":"2011","journal-title":"Eur. J. Pharmacol."},{"key":"ref_31","first-page":"152906","article-title":"Antidiabetic potential of gallic acid from Emblica officinalis: Improved glucose transporters and insulin sensitivity through PPAR-\u03b3 and Akt signaling","volume":"73","author":"Variya","year":"2020","journal-title":"Phytomed. Int. J. Phytother. Phytopharm."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"5257","DOI":"10.1021\/jf900730e","article-title":"Pu-erh tea attenuates hyperlipogenesis and induces hepatoma cells growth arrest through activating AMP-activated protein kinase (AMPK) in human HepG2 cells","volume":"57","author":"Way","year":"2009","journal-title":"J. Agric. Food Chem."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"606759","DOI":"10.3389\/fphar.2020.606759","article-title":"Gallic Acid Ameliorated Impaired Lipid Homeostasis in a Mouse Model of High-Fat Diet-and Streptozotocin-Induced NAFLD and Diabetes through Improvement of beta-oxidation and Ketogenesis","volume":"11","author":"Chao","year":"2020","journal-title":"Front. Pharmacol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"3918","DOI":"10.1074\/jbc.RA119.011849","article-title":"Ring finger protein 5 activates sterol regulatory element-binding protein 2 (SREBP2) to promote cholesterol biosynthesis via inducing polyubiquitination of SREBP chaperone SCAP","volume":"295","author":"Kuan","year":"2020","journal-title":"J. Biol. Chem."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"eabb2224","DOI":"10.1126\/science.abb2224","article-title":"A structure of human Scap bound to Insig-2 suggests how their interaction is regulated by sterols","volume":"371","author":"Yan","year":"2021","journal-title":"Science"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.jhep.2019.06.021","article-title":"The global epidemiology of NAFLD and NASH in patients with type 2 diabetes: A systematic review and meta-analysis","volume":"71","author":"Younossi","year":"2019","journal-title":"J. Hepatol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1756284819878046","DOI":"10.1177\/1756284819878046","article-title":"Effects of probiotics on nonalcoholic fatty liver disease: A systematic review and meta-analysis","volume":"12","author":"Tang","year":"2019","journal-title":"Ther. Adv. Gastroenterol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1002\/hep.29367","article-title":"The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver Diseases","volume":"67","author":"Chalasani","year":"2018","journal-title":"Hepatology"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1042\/CS20200446","article-title":"Non-alcoholic fatty liver disease: A metabolic burden promoting atherosclerosis","volume":"134","author":"Zhang","year":"2020","journal-title":"Clin. Sci."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"569","DOI":"10.7150\/ijbs.14027","article-title":"Dysregulation of the Low-Density Lipoprotein Receptor Pathway Is Involved in Lipid Disorder-Mediated Organ Injury","volume":"12","author":"Zhang","year":"2016","journal-title":"Int. J. Biol. Sci."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S1567-5688(15)50007-X","article-title":"The effect of ezetimibe on NAFLD","volume":"17","author":"Averna","year":"2015","journal-title":"Atheroscler. Suppl."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.atherosclerosis.2019.02.028","article-title":"Statins and nonalcoholic fatty liver disease in the era of precision medicine: More friends than foes","volume":"284","author":"Nascimbeni","year":"2019","journal-title":"Atherosclerosis"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Luo, C., Wang, D., Huang, W., Song, Y., Ge, L., Zhang, X., Yang, L., Lu, J., Tu, X., and Chen, Q. (2021). Feedback regulation of coronary artery disease susceptibility gene ADTRP and LDL receptors LDLR\/CD36\/LOX-1 in endothelia cell functions involved in atherosclerosis. Biochim. Biophys. Acta Mol. Basis Dis., 1867.","DOI":"10.1016\/j.bbadis.2021.166130"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1039\/C6FO01585A","article-title":"The hepatoprotective effect of Phyllanthus emblica L. fruit on high fat diet-induced non-alcoholic fatty liver disease (NAFLD) in SD rats","volume":"8","author":"Huang","year":"2017","journal-title":"Food Funct."},{"key":"ref_45","first-page":"240","article-title":"Gallic acid treats dust-induced NAFLD in rats by improving the liver\u2019s anti-oxidant capacity and inhibiting ROS\/NF\u03ba\u03b2\/TNF\u03b1 inflammatory pathway","volume":"24","author":"Fanaei","year":"2021","journal-title":"Iran. J. Basic Med. Sci."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/s41580-019-0190-7","article-title":"Mechanisms and regulation of cholesterol homeostasis","volume":"21","author":"Luo","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"10037","DOI":"10.1093\/nar\/gku652","article-title":"ZFP36L1 and ZFP36L2 control LDLR mRNA stability via the ERK-RSK pathway","volume":"42","author":"Adachi","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Choung, S., Kim, J.M., Joung, K.H., Lee, E.S., Kim, H.J., and Ku, B.J. (2019). Epidermal growth factor receptor inhibition attenuates non-alcoholic fatty liver disease in diet-induced obese mice. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0210828"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1080\/09168451.2019.1576498","article-title":"Ellagic acid affects mRNA expression levels of genes that regulate cholesterol metabolism in HepG2 cells","volume":"83","author":"Kubota","year":"2019","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/s41392-020-0207-x","article-title":"Therapeutic siRNA: State of the art","volume":"5","author":"Hu","year":"2020","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/j.jacl.2018.06.013","article-title":"PCSK9 inhibitors for prevention of atherosclerotic cardiovascular disease","volume":"12","author":"Bittner","year":"2018","journal-title":"J. Clin. Lipidol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/s41401-019-0274-0","article-title":"23,24-Dihydrocucurbitacin B promotes lipid clearance by dual transcriptional regulation of LDLR and PCSK9","volume":"41","author":"Li","year":"2020","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1186\/s12967-020-02362-4","article-title":"Beneficial impact of epigallocatechingallate on LDL-C through PCSK9\/LDLR pathway by blocking HNF1\u03b1 and activating FoxO3a","volume":"18","author":"Cui","year":"2020","journal-title":"J. Transl. Med."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/29\/9\/1999\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:34:00Z","timestamp":1760106840000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/29\/9\/1999"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,26]]},"references-count":53,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2024,5]]}},"alternative-id":["molecules29091999"],"URL":"https:\/\/doi.org\/10.3390\/molecules29091999","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,26]]}}}