{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T21:52:16Z","timestamp":1769118736596,"version":"3.49.0"},"reference-count":90,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2024,5,5]],"date-time":"2024-05-05T00:00:00Z","timestamp":1714867200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008252","name":"University of Udine","doi-asserted-by":"publisher","award":["501100008252"],"award-info":[{"award-number":["501100008252"]}],"id":[{"id":"10.13039\/501100008252","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>The cyclometalated terpyridine complexes [Ru(\u03b72-OAc)(NC-tpy)(PP)] (PP = dppb 1, (R,R)-Skewphos 4, (S,S)-Skewphos 5) are easily obtained from the acetate derivatives [Ru(\u03b72-OAc)2(PP)] (PP = dppb, (R,R)-Skewphos 2, (S,S)-Skewphos 3) and tpy in methanol by elimination of AcOH. The precursors 2, 3 are prepared from [Ru(\u03b72-OAc)2(PPh3)2] and Skewphos in cyclohexane. Conversely, the NNN complexes [Ru(\u03b71-OAc)(NNN-tpy)(PP)]OAc (PP = (R,R)-Skewphos 6, (S,S)-Skewphos 7) are synthesized in a one pot reaction from [Ru(\u03b72-OAc)2(PPh3)2], PP and tpy in methanol. The neutral NC-tpy 1, 4, 5 and cationic NNN-tpy 6, 7 complexes catalyze the transfer hydrogenation of acetophenone (S\/C = 1000) in 2-propanol with NaOiPr under light irradiation at 30 \u00b0C. Formation of (S)-1-phenylethanol has been observed with 4, 6 in a MeOH\/iPrOH mixture, whereas the R-enantiomer is obtained with 5, 7 (50\u201352% ee). The tpy complexes show cytotoxic activity against the anaplastic thyroid cancer 8505C and SW1736 cell lines (ED50 = 0.31\u20138.53 \u00b5M), with the cationic 7 displaying an ED50 of 0.31 \u00b5M, four times lower compared to the enantiomer 6.<\/jats:p>","DOI":"10.3390\/molecules29092146","type":"journal-article","created":{"date-parts":[[2024,5,6]],"date-time":"2024-05-06T14:26:11Z","timestamp":1715005571000},"page":"2146","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Cyclometalated and NNN Terpyridine Ruthenium Photocatalysts and Their Cytotoxic Activity"],"prefix":"10.3390","volume":"29","author":[{"given":"Maurizio","family":"Ballico","sequence":"first","affiliation":[{"name":"Dipartimento di Scienze Agroalimentari, Ambientali e Animali, Universit\u00e0 di Udine, Via Cotonificio 108, I-33100 Udine, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dario","family":"Alessi","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Agroalimentari, Ambientali e Animali, Universit\u00e0 di Udine, Via Cotonificio 108, I-33100 Udine, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0382-0525","authenticated-orcid":false,"given":"Eleonora","family":"Aneggi","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Agroalimentari, Ambientali e Animali, Universit\u00e0 di Udine, Via Cotonificio 108, I-33100 Udine, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Busato","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Agroalimentari, Ambientali e Animali, Universit\u00e0 di Udine, Via Cotonificio 108, I-33100 Udine, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7765-1715","authenticated-orcid":false,"given":"Daniele","family":"Zuccaccia","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Agroalimentari, Ambientali e Animali, Universit\u00e0 di Udine, Via Cotonificio 108, I-33100 Udine, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorenzo","family":"Allegri","sequence":"additional","affiliation":[{"name":"Dipartimento di Medicina, Istituto di Genetica Medica, Universit\u00e0 di Udine, Via Chiusaforte, F3, I-33100 Udine, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Damante","sequence":"additional","affiliation":[{"name":"Dipartimento di Medicina, Istituto di Genetica Medica, Universit\u00e0 di Udine, Via Chiusaforte, F3, I-33100 Udine, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Jandl","sequence":"additional","affiliation":[{"name":"Department of Chemistry & Catalysis Research Center, Technische Universit\u00e4t M\u00fcnchen, Ernst-Otto-Fischer-Str. 1, 85748 Garching bei M\u00fcnchen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2648-1848","authenticated-orcid":false,"given":"Walter","family":"Baratta","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Agroalimentari, Ambientali e Animali, Universit\u00e0 di Udine, Via Cotonificio 108, I-33100 Udine, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,5,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1021\/op2003826","article-title":"Large-Scale Carbonyl Reductions in the Pharmaceutical Industry","volume":"16","author":"Magano","year":"2012","journal-title":"Org. 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