{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T06:05:50Z","timestamp":1778825150662,"version":"3.51.4"},"reference-count":50,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T00:00:00Z","timestamp":1715472000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas and Consejo Nacional de Ciencia y Tecnolog\u00eda, M\u00e9xico","award":["CF 2019\/137725"],"award-info":[{"award-number":["CF 2019\/137725"]}]},{"name":"Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas and Consejo Nacional de Ciencia y Tecnolog\u00eda, M\u00e9xico","award":["UNAM # IN200522"],"award-info":[{"award-number":["UNAM # IN200522"]}]},{"name":"Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas and Consejo Nacional de Ciencia y Tecnolog\u00eda, M\u00e9xico","award":["IA203924"],"award-info":[{"award-number":["IA203924"]}]},{"name":"PAPIIT","award":["CF 2019\/137725"],"award-info":[{"award-number":["CF 2019\/137725"]}]},{"name":"PAPIIT","award":["UNAM # IN200522"],"award-info":[{"award-number":["UNAM # IN200522"]}]},{"name":"PAPIIT","award":["IA203924"],"award-info":[{"award-number":["IA203924"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>The Cupressaceae family includes species considered to be medicinal. Their essential oil is used for headaches, colds, cough, and bronchitis. Cedar trees like Chamaecyparis lawsoniana (C. lawsoniana) are commonly found in urban areas. We investigated whether C. lawsoniana exerts some of its effects by modifying airway smooth muscle (ASM) contractility. The leaves of C. lawsoniana (363 g) were pulverized mechanically, and extracts were obtained by successive maceration 1:10 (w:w) with methanol\/CHCl3. Guinea pig tracheal rings were contracted with KCl, tetraethylammonium (TEA), histamine (HIS), or carbachol (Cch) in organ baths. In the Cch experiments, tissues were pre-incubated with D-600, an antagonist of L-type voltage-dependent Ca2+ channels (L-VDCC) before the addition of C. lawsoniana. Interestingly, at different concentrations, C. lawsoniana diminished the tracheal contractions induced by KCl, TEA, HIS, and Cch. In ASM cells, C. lawsoniana significantly diminished L-type Ca2+ currents. ASM cells stimulated with Cch produced a transient Ca2+ peak followed by a sustained plateau maintained by L-VDCC and store-operated Ca2+ channels (SOCC). C. lawsoniana almost abolished this last response. These results show that C. lawsoniana, and its active metabolite quercetin, relax the ASM by inhibiting the L-VDCC and SOCC; further studies must be performed to obtain the complete set of metabolites of the extract and study at length their pharmacological properties.<\/jats:p>","DOI":"10.3390\/molecules29102284","type":"journal-article","created":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T09:28:25Z","timestamp":1715592505000},"page":"2284","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Chamaecyparis lawsoniana and Its Active Compound Quercetin as Ca2+ Inhibitors in the Contraction of Airway Smooth Muscle"],"prefix":"10.3390","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2649-8751","authenticated-orcid":false,"given":"Edgar","family":"Flores-Soto","sequence":"first","affiliation":[{"name":"Departamento de Farmacolog\u00eda, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Avenida Universidad No. 3000, Alcald\u00eda de Coyoac\u00e1n, C.P., Mexico City 04510, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5887-6177","authenticated-orcid":false,"given":"Bianca S.","family":"Romero-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Departamento de Farmacolog\u00eda, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Avenida Universidad No. 3000, Alcald\u00eda de Coyoac\u00e1n, C.P., Mexico City 04510, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0692-6931","authenticated-orcid":false,"given":"H\u00e9ctor","family":"Sol\u00eds-Chagoy\u00e1n","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n en Ciencias Cognitivas, Universidad Aut\u00f3noma del Estado de Morelos, Avenida Universidad 1001, Col. Chamilpa, C.P., Cuernavaca 62209, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7362-0070","authenticated-orcid":false,"given":"Edgar A.","family":"Estrella-Parra","sequence":"additional","affiliation":[{"name":"Laboratorio de Fitoqu\u00edmica, Unidad de Biolog\u00eda Tecnolog\u00eda y Prototipos, FES-Iztacala, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Avenida de los Barrios No. 1, Los Reyes Iztacala, C.P., Tlalnepantla 54090, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0552-5792","authenticated-orcid":false,"given":"Jose G.","family":"Avila-Acevedo","sequence":"additional","affiliation":[{"name":"Laboratorio de Fitoqu\u00edmica, Unidad de Biolog\u00eda Tecnolog\u00eda y Prototipos, FES-Iztacala, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Avenida de los Barrios No. 1, Los Reyes Iztacala, C.P., Tlalnepantla 54090, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7186-8067","authenticated-orcid":false,"given":"Juan C.","family":"Gomez-Verjan","sequence":"additional","affiliation":[{"name":"Direcci\u00f3n de Investigaci\u00f3n, Instituto Nacional de Geriatr\u00eda (INGER), Anillo Perif\u00e9rico. 2767, San Jer\u00f3nimo L\u00eddice, La Magdalena, C.P., Mexico City 10200, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6226-7363","authenticated-orcid":false,"given":"Jorge","family":"Reyes-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Departamento de Farmacolog\u00eda, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Avenida Universidad No. 3000, Alcald\u00eda de Coyoac\u00e1n, C.P., Mexico City 04510, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8762-6798","authenticated-orcid":false,"given":"Mar\u00eda F.","family":"Casas-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Departamento de Farmacolog\u00eda, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Avenida Universidad No. 3000, Alcald\u00eda de Coyoac\u00e1n, C.P., Mexico City 04510, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1292-9418","authenticated-orcid":false,"given":"Bettina","family":"Sommer","sequence":"additional","affiliation":[{"name":"Departamento de Investigaci\u00f3n en Hiperreactividad Bronquial, Instituto Nacional de Enfermedades Respiratorias \u201cIsmael Cosio Villegas\u201d, Calz. De Tlalpan 4502, Col. Secci\u00f3n XVI, Alcald\u00eda de Tlalpan, C.P., Mexico City 14080, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8329-4918","authenticated-orcid":false,"given":"Luis M.","family":"Monta\u00f1o","sequence":"additional","affiliation":[{"name":"Departamento de Farmacolog\u00eda, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Avenida Universidad No. 3000, Alcald\u00eda de Coyoac\u00e1n, C.P., Mexico City 04510, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,5,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"210","DOI":"10.20471\/acc.2017.56.02.03","article-title":"Correlation Between Occurrence and Deterioration of Respiratory Diseases and Air Pollution Within the Legally Permissible Limits","volume":"56","author":"Trnjar","year":"2017","journal-title":"Acta Clin. 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