{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T03:05:32Z","timestamp":1780887932687,"version":"3.54.1"},"reference-count":46,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T00:00:00Z","timestamp":1715644800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>As a development of our research on biocompatible glycoconjugate probes and specifically multi-chromophoric systems, herein, we report the synthesis and early bactericidal tests of two luminescent glycoconjugates whose basic structure is characterized by two boron dipyrromethene difluoride (BODIPY) moieties and three galactoside rings mounted on an oligophenylene ethynylene (OPE) skeleton. BODIPY fluorophores have found widespread application in many branches of biology in the last few decades. In particular, molecular platforms showing two different BODIPY groups have unique photophysical behavior useful in fluorescence imaging. Construction of the complex architecture of the new probes is accomplished through a convergent route that exploits a series of copper-free Heck\u2013Cassar\u2013Sonogashira cross-couplings. The great emergency due to the proliferation of bacterial infections, in conjunction with growing antibiotic resistance, requires the production of new multifunctional drugs and efficient methods for their targeted delivery to control bacteria-associated diseases. Preliminary studies of the glycoconjugate properties as antibacterial agents against representatives of Gram-negative (P. aeruginosa) and Gram-positive (S. aureus) pathogens, which are associated with chronic infections, indicated significant bactericidal activity ascribable to their structural features.<\/jats:p>","DOI":"10.3390\/molecules29102299","type":"journal-article","created":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T06:28:12Z","timestamp":1715668092000},"page":"2299","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Synthesis of Bodipy-Tagged Galactoconjugates and Evaluation of Their Antibacterial Properties"],"prefix":"10.3390","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6978-1779","authenticated-orcid":false,"given":"Chiara Maria Antonietta","family":"Gangemi","sequence":"first","affiliation":[{"name":"Dipartimento di Scienze Chimiche, Biologiche, Farmaceutiche ed Ambientali, Universit\u00e0 degli Studi di Messina, V.le F. Stagno D\u2019Alcontres 31, 98166 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maura","family":"Monforte","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Chimiche, Biologiche, Farmaceutiche ed Ambientali, Universit\u00e0 degli Studi di Messina, V.le F. Stagno D\u2019Alcontres 31, 98166 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0781-3580","authenticated-orcid":false,"given":"Antonino","family":"Arrigo","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Chimiche, Biologiche, Farmaceutiche ed Ambientali, Universit\u00e0 degli Studi di Messina, V.le F. Stagno D\u2019Alcontres 31, 98166 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7914-5653","authenticated-orcid":false,"given":"Paola Maria","family":"Bonaccorsi","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Chimiche, Biologiche, Farmaceutiche ed Ambientali, Universit\u00e0 degli Studi di Messina, V.le F. Stagno D\u2019Alcontres 31, 98166 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Conoci","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Chimiche, Biologiche, Farmaceutiche ed Ambientali, Universit\u00e0 degli Studi di Messina, V.le F. Stagno D\u2019Alcontres 31, 98166 Messina, Italy"},{"name":"Dipartimento di Chimica \u201cGiacomo Ciamician\u201d, Universit\u00e0 di Bologna, Via Francesco Selmi, 2, 40126 Bologna, Italy"},{"name":"LAB Sense Beyond Nano\u2014URT Department of Sciences Physics and Technologies of Matter (DSFTM) CNR, 98166 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4582-4850","authenticated-orcid":false,"given":"Antonella","family":"Iaconis","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Chimiche, Biologiche, Farmaceutiche ed Ambientali, Universit\u00e0 degli Studi di Messina, V.le F. Stagno D\u2019Alcontres 31, 98166 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8579-859X","authenticated-orcid":false,"given":"Fausto","family":"Puntoriero","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Chimiche, Biologiche, Farmaceutiche ed Ambientali, Universit\u00e0 degli Studi di Messina, V.le F. Stagno D\u2019Alcontres 31, 98166 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2104-5465","authenticated-orcid":false,"given":"Domenico","family":"Franco","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Chimiche, Biologiche, Farmaceutiche ed Ambientali, Universit\u00e0 degli Studi di Messina, V.le F. Stagno D\u2019Alcontres 31, 98166 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2415-5483","authenticated-orcid":false,"given":"Anna","family":"Barattucci","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Chimiche, Biologiche, Farmaceutiche ed Ambientali, Universit\u00e0 degli Studi di Messina, V.le F. Stagno D\u2019Alcontres 31, 98166 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,5,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"7036","DOI":"10.1039\/D3CS00032J","article-title":"Glycosidase-Targeting Small Molecules for Biological and Therapeutic Applications","volume":"52","author":"Kim","year":"2023","journal-title":"Chem. Soc. 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