{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T03:04:07Z","timestamp":1791083047715,"version":"4.1.0"},"reference-count":183,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T00:00:00Z","timestamp":1715904000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Scientific research project of Traditional Chinese Medicine of Henan Province","award":["20-21ZY3012"],"award-info":[{"award-number":["20-21ZY3012"]}]},{"name":"Scientific research project of Traditional Chinese Medicine of Henan Province","award":["2022ZYFY06"],"award-info":[{"award-number":["2022ZYFY06"]}]},{"name":"Scientific research project of Traditional Chinese Medicine of Henan Province","award":["82274274"],"award-info":[{"award-number":["82274274"]}]},{"name":"Traditional Chinese Medicine Research Project for COVID-19 of Henan Province","award":["20-21ZY3012"],"award-info":[{"award-number":["20-21ZY3012"]}]},{"name":"Traditional Chinese Medicine Research Project for COVID-19 of Henan Province","award":["2022ZYFY06"],"award-info":[{"award-number":["2022ZYFY06"]}]},{"name":"Traditional Chinese Medicine Research Project for COVID-19 of Henan Province","award":["82274274"],"award-info":[{"award-number":["82274274"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["20-21ZY3012"],"award-info":[{"award-number":["20-21ZY3012"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2022ZYFY06"],"award-info":[{"award-number":["2022ZYFY06"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82274274"],"award-info":[{"award-number":["82274274"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Influenza A (H1N1) viruses are prone to antigenic mutations and are more variable than other influenza viruses. Therefore, they have caused continuous harm to human public health since the pandemic in 2009 and in recent times. Influenza A (H1N1) can be prevented and treated in various ways, such as direct inhibition of the virus and regulation of human immunity. Among antiviral drugs, the use of natural products in treating influenza has a long history, and natural medicine has been widely considered the focus of development programs for new, safe anti-influenza drugs. In this paper, we focus on influenza A (H1N1) and summarize the natural product-derived phytochemicals for influenza A virus (H1N1) prevention and treatment, including marine natural products, flavonoids, alkaloids, terpenoids and their derivatives, phenols and their derivatives, polysaccharides, and derivatives of natural products for prevention and treatment of influenza A (H1N1) virus. We further discuss the toxicity and antiviral mechanism against influenza A (H1N1) as well as the druggability of natural products. We hope that this review will facilitate the study of the role of natural products against influenza A (H1N1) activity and provide a promising alternative for further anti-influenza A drug development.<\/jats:p>","DOI":"10.3390\/molecules29102371","type":"journal-article","created":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T12:02:23Z","timestamp":1715947343000},"page":"2371","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Natural Product-Derived Phytochemicals for Influenza A Virus (H1N1) Prevention and Treatment"],"prefix":"10.3390","volume":"29","author":[{"given":"Ruichen","family":"Li","sequence":"first","affiliation":[{"name":"College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianru","family":"Han","sequence":"additional","affiliation":[{"name":"Foreign Language Education Department, Zhengzhou Shuqing Medical College, Zhengzhou 450064, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaokun","family":"Li","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinguang","family":"Liu","sequence":"additional","affiliation":[{"name":"Co-Construction Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases by Henan & Education Ministry of China, Zhengzhou 450003, China"},{"name":"Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou, 450003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijie","family":"Jiao","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450003, China"},{"name":"Department of Pharmacy, Henan Province Hospital of Traditional Chinese Medicine, Zhengzhou 450046, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,5,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1038\/nature08182","article-title":"Origins and evolutionary genomics of the 2009 swine-origin H1N1 influenza A epidemic","volume":"459","author":"Smith","year":"2009","journal-title":"Nature"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"15","DOI":"10.3201\/eid1209.05-0979","article-title":"1918 Influenza: The mother of all pandemics","volume":"12","author":"Taubenberger","year":"2006","journal-title":"Emerg. 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