{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T16:29:03Z","timestamp":1789144143340,"version":"build-2803163510"},"reference-count":45,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2024,5,19]],"date-time":"2024-05-19T00:00:00Z","timestamp":1716076800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Monitoring hydrogen sulfide (H2S) in living organisms is very important because H2S acts as a regulator in many physiological and pathological processes. Upregulation of endogenous H2S concentration has been shown to be closely related to the occurrence and development of tumors, atherosclerosis, neurodegenerative diseases and diabetes. Herin, a novel fluorescent probe HND with aggregation-induced emission was designed. Impressively, HND exhibited a high selectivity, fast response (1 min) and low detection limit (0.61 \u03bcM) for H2S in PBS buffer (10 mM, pH = 7.42). Moreover, the reaction mechanism between HND and H2S was conducted by Job\u2019s plot, HR-MS, and DFT. In particular, HND was successfully employed to detect H2S in HeLa cells.<\/jats:p>","DOI":"10.3390\/molecules29102386","type":"journal-article","created":{"date-parts":[[2024,5,20]],"date-time":"2024-05-20T06:31:58Z","timestamp":1716186718000},"page":"2386","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["An Aggregation-Induced Fluorescence Probe for Detection H2S and Its Application in Cell Imaging"],"prefix":"10.3390","volume":"29","author":[{"given":"Xin-Hui","family":"Tang","sequence":"first","affiliation":[{"name":"School of Pharmacy, Yancheng Teachers University, Yancheng 224051, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao-Na","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Yancheng Teachers University, Yancheng 224051, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Ling","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Yancheng Teachers University, Yancheng 224051, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9743-2069","authenticated-orcid":false,"given":"Qing-Ming","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Yancheng Teachers University, Yancheng 224051, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,5,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1126\/science.1162667","article-title":"H2S as a Physiologic Vasorelaxant: Hypertension in Mice with Deletion of Cystathionine \u03b3-Lyase","volume":"322","author":"Yang","year":"2008","journal-title":"Science"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.tips.2007.09.003","article-title":"Hydrogen sulfide-releasing anti-inflammatory drugs","volume":"28","author":"Wallace","year":"2007","journal-title":"Trends Pharmacol. 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