{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T03:31:42Z","timestamp":1771817502941,"version":"3.50.1"},"reference-count":36,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2024,6,7]],"date-time":"2024-06-07T00:00:00Z","timestamp":1717718400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Rede Norte-Nordeste de Fitoter\u00e1picos","award":["46.5536\/2014-0"],"award-info":[{"award-number":["46.5536\/2014-0"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Seven new abietane diterpenoids, comprising medusanthol A\u2013G (1\u20133, 5, 7\u20139) and two previously identified analogs (4 and 6), were isolated from the hexane extract of the aerial parts of Medusantha martiusii. The structures of the compounds were elucidated by HRESIMS, 1D\/2D NMR spectroscopic data, IR spectroscopy, NMR calculations with DP4+ probability analysis, and ECD calculations. The anti-neuroinflammatory potential of compounds 1\u20137 was evaluated by determining their ability to inhibit the production of nitric oxide (NO) and the proinflammatory cytokine TNF-\u03b1 in BV2 microglia stimulated with LPS and IFN-\u03b3. Compounds 1\u20134 and 7 exhibited decreased NO levels at a concentration of 12.5 \u00b5M. Compound 1 demonstrated strong activity with an IC50 of 3.12 \u00b5M, and compound 2 had an IC50 of 15.53 \u00b5M; both compounds effectively reduced NO levels compared to the positive control quercetin (IC50 11.8 \u00b5M). Additionally, both compounds significantly decreased TNF-\u03b1 levels, indicating their potential as promising anti-neuroinflammatory agents.<\/jats:p>","DOI":"10.3390\/molecules29122723","type":"journal-article","created":{"date-parts":[[2024,6,7]],"date-time":"2024-06-07T10:43:42Z","timestamp":1717757022000},"page":"2723","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Abietane Diterpenes from Medusantha\u00a0martiusii and Their Anti-Neuroinflammatory Activity"],"prefix":"10.3390","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-0758-3395","authenticated-orcid":false,"given":"Edileuza B. de","family":"Assis","sequence":"first","affiliation":[{"name":"Postgraduate Program in Natural and Synthetic Bioactive Products, Federal University of Paraiba, Jo\u00e3o Pessoa 58051-900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigo S. de","family":"Andrade","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Natural and Synthetic Bioactive Products, Federal University of Paraiba, Jo\u00e3o Pessoa 58051-900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6733-9285","authenticated-orcid":false,"given":"Joanda P. R. e","family":"Silva","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Natural and Synthetic Bioactive Products, Federal University of Paraiba, Jo\u00e3o Pessoa 58051-900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucas H.","family":"Martorano","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry, Fluminense Federal University, Niter\u00f3i 24020-141, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7269-891X","authenticated-orcid":false,"given":"Geraldo M. W.","family":"Amorim","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Natural and Synthetic Bioactive Products, Federal University of Paraiba, Jo\u00e3o Pessoa 58051-900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4349-0236","authenticated-orcid":false,"given":"Paulo B. A.","family":"Loureiro","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Natural and Synthetic Bioactive Products, Federal University of Paraiba, Jo\u00e3o Pessoa 58051-900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5620-8095","authenticated-orcid":false,"given":"Lucas S.","family":"Abreu","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry, Fluminense Federal University, Niter\u00f3i 24020-141, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7740-034X","authenticated-orcid":false,"given":"Marianna V.","family":"Sobral","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Natural and Synthetic Bioactive Products, Federal University of Paraiba, Jo\u00e3o Pessoa 58051-900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4863-8057","authenticated-orcid":false,"given":"Marcus T.","family":"Scotti","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Natural and Synthetic Bioactive Products, Federal University of Paraiba, Jo\u00e3o Pessoa 58051-900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3711-6659","authenticated-orcid":false,"given":"Fernando M. dos","family":"Santos Junior","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry, Fluminense Federal University, Niter\u00f3i 24020-141, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8888-0975","authenticated-orcid":false,"given":"Maria de F\u00e1tima","family":"Agra","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Natural and Synthetic Bioactive Products, Federal University of Paraiba, Jo\u00e3o Pessoa 58051-900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0293-2605","authenticated-orcid":false,"given":"Josean F.","family":"Tavares","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Natural and Synthetic Bioactive Products, Federal University of Paraiba, Jo\u00e3o Pessoa 58051-900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3451-8468","authenticated-orcid":false,"given":"Marcelo S. da","family":"Silva","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Natural and Synthetic Bioactive Products, Federal University of Paraiba, Jo\u00e3o Pessoa 58051-900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.11646\/phytotaxa.58.1.1","article-title":"A Generic Revision and New Combinations in the Hyptidinae (Lamiaceae), Based on Molecular and Morphological Evidence","volume":"58","author":"Harley","year":"2012","journal-title":"Phytotaxa"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e01762018","DOI":"10.1590\/2175-7860202071086","article-title":"Flora da Para\u00edba, Brasil: Subfam\u00edlia Nepetoideae (Lamiaceae)","volume":"71","author":"Monteiro","year":"2020","journal-title":"Rodrigu\u00e9sia"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"dsaa016","DOI":"10.1093\/dnares\/dsaa016","article-title":"Genome Sequencing of Four Culinary Herbs Reveals Terpenoid Genes Underlying Chemodiversity in the Nepetoideae","volume":"27","author":"Bornowski","year":"2020","journal-title":"DNA Res."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Ortiz-Mendoza, N., Mart\u00ednez-Gordillo, M.J., Mart\u00ednez-Ambriz, E., Basurto-Pe\u00f1a, F.A., Gonz\u00e1lez-Trujano, M.E., and Aguirre-Hern\u00e1ndez, E. 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