{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T01:26:57Z","timestamp":1772587617468,"version":"3.50.1"},"reference-count":28,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T00:00:00Z","timestamp":1718064000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Natural Science Foundation of China","award":["52303132"],"award-info":[{"award-number":["52303132"]}]},{"name":"National Natural Science Foundation of China","award":["2022CFB710"],"award-info":[{"award-number":["2022CFB710"]}]},{"name":"National Natural Science Foundation of China","award":["2020020601012252"],"award-info":[{"award-number":["2020020601012252"]}]},{"name":"Hubei Province Natural Science Foundation for Youths","award":["52303132"],"award-info":[{"award-number":["52303132"]}]},{"name":"Hubei Province Natural Science Foundation for Youths","award":["2022CFB710"],"award-info":[{"award-number":["2022CFB710"]}]},{"name":"Hubei Province Natural Science Foundation for Youths","award":["2020020601012252"],"award-info":[{"award-number":["2020020601012252"]}]},{"name":"Frontier Project of the Application Foundation of Wuhan Former Funded Science and Technology Program","award":["52303132"],"award-info":[{"award-number":["52303132"]}]},{"name":"Frontier Project of the Application Foundation of Wuhan Former Funded Science and Technology Program","award":["2022CFB710"],"award-info":[{"award-number":["2022CFB710"]}]},{"name":"Frontier Project of the Application Foundation of Wuhan Former Funded Science and Technology Program","award":["2020020601012252"],"award-info":[{"award-number":["2020020601012252"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>A tumor-targeting fluorescent probe has attracted increasing interest in fluorescent imaging for the noninvasive detection of cancers in recent years. Sulfonamide-containing naphthalimide derivatives (SN-2NI, SD-NI) were synthesized by the incorporation of N-butyl-4-ethyldiamino-1,8-naphthalene imide (NI) into sulfonamide (SN) and sulfadiazine (SD) as the tumor-targeting groups, respectively. These derivatives were further characterized by mass spectrometry (MS), nuclear magnetic resonance spectroscopy (1H NMR), Fourier transform infrared spectroscopy (FT-IR), ultraviolet\u2013visible spectroscopy (UV), and a fluorescence assay. In vitro properties, including cell cytotoxicity and the cell uptake of tumor cells, were also evaluated. Sulfonamide-containing naphthalimide derivatives possessed low cell cytotoxicity to B16F10 melanoma cells. Moreover, SN-2NI and SD-NI can be taken up highly by B16F10 cells and then achieve good green fluorescent images in B16F10 cells. Therefore, sulfonamide-containing naphthalimide derivatives can be considered to be the potential probes used to target fluorescent imaging in tumors.<\/jats:p>","DOI":"10.3390\/molecules29122774","type":"journal-article","created":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T11:58:58Z","timestamp":1718107138000},"page":"2774","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Synthesis and Characterization of Sulfonamide-Containing Naphthalimides as Fluorescent Probes"],"prefix":"10.3390","volume":"29","author":[{"given":"Zhi-Wei","family":"Liu","sequence":"first","affiliation":[{"name":"College of Chemical and Material Engineering, Quzhou University, Quzhou 324000, China"},{"name":"School of Materials Science and Engineering, Wuhan Institute of Technology, Wuhan 430205, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fan","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering, Wuhan Institute of Technology, Wuhan 430205, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun-Tao","family":"Shao","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering, Wuhan Institute of Technology, Wuhan 430205, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2649-9108","authenticated-orcid":false,"given":"Guo-Ping","family":"Yan","sequence":"additional","affiliation":[{"name":"College of Chemical and Material Engineering, Quzhou University, Quzhou 324000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiang-Yu","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering, Wuhan Institute of Technology, Wuhan 430205, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1007\/s10895-020-02615-x","article-title":"A new endoplasmic reticulum (ER)-targeting fluorescent probe for the imaging of cysteine in living cells","volume":"30","author":"Zhou","year":"2020","journal-title":"J. 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