{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T22:49:19Z","timestamp":1792536559161,"version":"4.5.0"},"reference-count":46,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T00:00:00Z","timestamp":1718150400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Bangladesh Agricultural University Research System (BAURES), Bangladesh","award":["2019\/61\/BAU"],"award-info":[{"award-number":["2019\/61\/BAU"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Turmeric (Curcuma longa) contains curcumin, demethoxycurcumin (DMC), and bisdemethoxycurcumin (BDMC). Nevertheless, curcumin is the most researched active ingredient for its numerous pharmacological effects. We investigated the impact of these curcuminoids found in Ryudai gold, an approved cultivar of Curcuma longa, on wound healing, inflammation, and diabetes. Sub-planter injections of carrageenan induced acute paw inflammation in rats. The wound-healing ability of 1% curcuminoids was examined by making a 6 mm round wound on the shaved dorsum of the mice with a biopsy punch. A single intraperitoneal injection of streptozotocin (50 mg\/kg) was used to induce diabetes in mice. Curcuminoids at a dose rate of 100 mg\/kg body weight were used with feed and as a gastric gavage to treat diabetes and inflammation in experimental animals. Paw thickness was measured at 1, 3, and 6 h following carrageenan injection. After three hours, mean paw volume was 58% in carrageenan-injected mice, which was 35%, 37%, and 31% in the curcumin, DMC, and BDMC groups, respectively. Histopathology of the paw tissue demonstrated severe infiltration of inflammatory cells and thickening of the dermis, which were remarkably improved by the curcuminoids. The wound-healing abilities were significantly higher in the curcumin- (95.0%), DMC- (93.17%), and BDMC-treated (89.0%) groups, in comparison to that of the control (65.09%) group at day nine. There were no significant differences in wound-healing activity among the groups treated with 1% curcuminoids throughout the study. Streptozotocin-induced diabetes was characterized by an increased blood glucose (552.2 mg\/dL) and decreased body weight (31.2 g), compared to that of the control rats (145.6 mg\/dL and 46.8 g blood glucose and body weight, respectively). It also caused an increase in serum alanine aminotransferase (ALT; 44.2 U\/L) and aspartate aminotransferase (AST; 55.8 U\/L) compared to that of the control group (18.6 U\/L and 20.1 U\/L, respectively). Histopathological examination of the liver showed that diabetes caused hepatic cellular necrosis, congestion of the central vein, and parenchymatous degeneration. However, all three curcuminoids significantly decreased blood glucose levels, ALT, and AST and improved the histopathological score of the liver. These results evidenced that not only curcumin but also DMC and BDMC have potent anti-inflammatory, wound healing, and anti-diabetic efficacy, and the Ryudai gold variety of turmeric could be used as a functional food supplement.<\/jats:p>","DOI":"10.3390\/molecules29122795","type":"journal-article","created":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T06:47:30Z","timestamp":1718174850000},"page":"2795","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Anti-Inflammatory, Wound Healing, and Anti-Diabetic Effects of Pure Active Compounds Present in the Ryudai Gold Variety of Curcuma longa"],"prefix":"10.3390","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4253-6711","authenticated-orcid":false,"given":"Md Zahorul","family":"Islam","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Faculty of Veterinary Science, Bangladesh Agricultural University, Mymensingh 2202, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesmin","family":"Akter","sequence":"additional","affiliation":[{"name":"Faculty of Agriculture, University of the Ryukyus, Okinawa 903-0213, Japan"},{"name":"The United Graduate School of Agricultural Sciences, Kagoshima University, Kagoshima 890-0065, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md Amzad","family":"Hossain","sequence":"additional","affiliation":[{"name":"Faculty of Agriculture, University of the Ryukyus, Okinawa 903-0213, Japan"},{"name":"The United Graduate School of Agricultural Sciences, Kagoshima University, Kagoshima 890-0065, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md Shafiqul","family":"Islam","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Veterinary Science, Bangladesh Agricultural University, Mymensingh 2202, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Purba","family":"Islam","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Veterinary Science, Bangladesh Agricultural University, Mymensingh 2202, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chayon","family":"Goswami","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Faculty of Agriculture, Bangladesh Agricultural University, Mymensingh 2202, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ha Thi Thanh","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pharmacology, Faculty of Veterinary Medicine, Vietnam National University of Agriculture, Trau Quy Crossing, Gia Lam District, Hanoi 131000, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1980-2869","authenticated-orcid":false,"given":"Atsushi","family":"Miyamoto","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pharmacology, Joint Faculty of Veterinary Medicine, Kagoshima University, 1-21-24 Korimoto, Kagoshima 890-0065, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2516","DOI":"10.1002\/elps.201500253","article-title":"The sensitive capillary electrophoretic-LIF method for simultaneous determination of curcuminoids in turmeric by enhancing fluorescence intensities of molecules upon inclusion into (2-hydroxypropyl)-\u03b2-cyclodextrin","volume":"36","author":"Hashemi","year":"2015","journal-title":"Electrophoresis"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1007\/s11094-018-1815-4","article-title":"Antifungal Activity of Various Species and Strains of Turmeric (Curcuma spp.) Against Fusarium Solani Sensu Lato","volume":"52","author":"Akter","year":"2018","journal-title":"Pharm. 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