{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T19:01:28Z","timestamp":1772046088050,"version":"3.50.1"},"reference-count":43,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2024,6,23]],"date-time":"2024-06-23T00:00:00Z","timestamp":1719100800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Research Foundation of Korea","award":["#NRF-2018 R1A6A1A03025108"],"award-info":[{"award-number":["#NRF-2018 R1A6A1A03025108"]}]},{"name":"National Research Foundation of Korea","award":["2022R1A2C2009911"],"award-info":[{"award-number":["2022R1A2C2009911"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Piper attenuatum Buch-Ham, a perennial woody vine belonging to the Piperaceae family, is traditionally used in Southeast Asia for treating various ailments such as malaria, headache, and hepatitis. This study described the isolation and identification of three new compounds, piperamides I-III (1\u20133), which belong to the maleimide-type alkaloid skeletons, along with fifteen known compounds (4\u201318) from the methanol extract of the aerial parts of P. attnuatum. Their chemical structures were elucidated using spectroscopic methods (UV, IR, ESI-Q-TOF-MS, and 1D\/2D NMR). All the isolates were evaluated for their ability to inhibit IL-6 activity in the human embryonic kidney-Blue\u2122 IL-6 cell line and their cytotoxic activity against ovarian cancer cell lines (SKOV3\/SKOV3-TR) and chemotherapy-resistant variants (cisplatin-resistant A2780\/paclitaxel-resistant SKOV3). The compounds 3, 4, 11, 12, 17, and 18 exhibited IL-6 inhibition comparable to that of the positive control bazedoxifene. Notably, compound 12 displayed the most potent anticancer effect against all the tested cancer cell lines. These findings highlight the importance of researching the diverse activities of both known and newly discovered natural products to fully unlock their potential therapeutic benefits.<\/jats:p>","DOI":"10.3390\/molecules29132981","type":"journal-article","created":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T05:16:18Z","timestamp":1719206178000},"page":"2981","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["IL-6 Inhibitory Compounds from the Aerial Parts of Piper attenuatum and Their Anticancer Activities on Ovarian Cancer Cell Lines"],"prefix":"10.3390","volume":"29","author":[{"given":"Hye Jin","family":"Kim","sequence":"first","affiliation":[{"name":"College of Pharmacy, Integrated Research Institute of Pharmaceutical Sciences, The Catholic University of Korea, Bucheon 14662, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lee Kyung","family":"Kim","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Integrated Research Institute of Pharmaceutical Sciences, BK21FOUR Team for Advanced Program for Smart Pharma Leaders, The Catholic University of Korea, Bucheon 14662, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Kim","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Integrated Research Institute of Pharmaceutical Sciences, The Catholic University of Korea, Bucheon 14662, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khin Myo","family":"Htwe","sequence":"additional","affiliation":[{"name":"Popa Mountain National Park, Forest Department, Kyaukpadaung Township, Mandalay Division, Kyaukpadaung 05241, Myanmar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tae-Hwe","family":"Heo","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Integrated Research Institute of Pharmaceutical Sciences, BK21FOUR Team for Advanced Program for Smart Pharma Leaders, The Catholic University of Korea, Bucheon 14662, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kye Jung","family":"Shin","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Integrated Research Institute of Pharmaceutical Sciences, The Catholic University of Korea, Bucheon 14662, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6122-6906","authenticated-orcid":false,"given":"Hee Jung","family":"Kim","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Integrated Research Institute of Pharmaceutical Sciences, BK21FOUR Team for Advanced Program for Smart Pharma Leaders, The Catholic University of Korea, Bucheon 14662, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kee Dong","family":"Yoon","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Integrated Research Institute of Pharmaceutical Sciences, The Catholic University of Korea, Bucheon 14662, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s12686-009-9051-6","article-title":"Isolation and characterization of microsatellite loci in the black pepper, Piper nigrum L. 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