{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T09:12:21Z","timestamp":1770887541280,"version":"3.50.1"},"reference-count":32,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T00:00:00Z","timestamp":1719360000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Atat\u00fcrk University Scientific Research Projects Coordination Office","award":["TYL-2023-11978"],"award-info":[{"award-number":["TYL-2023-11978"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>In this study, the isolation of compounds from the aerial parts of Morina persica L. and the antimicrobial, antioxidant and antityrosinase activities of various polarity extracts and isolated compounds were investigated. Column chromatography methods were used for isolation. A microdilution method was used to determine antimicrobial activity; Folin-Ciocalteu method was used to determine total phenolic content; DPPH and ABTS radical scavenging- capacity methods were used to determine antioxidant activity; and a mushroom tyrosinase method was used to determine antityrosinase activity. Kaempferol-3-O-\u03b2-glucopyranoside (astragalin) and quercetin-3-O-rutinoside (rutin) were isolated from M. persica. The extracts and compounds showed higher activity against Staphylococcus aureus and Enterococcus faecalis than other tested bacteria. The highest phenolic content, DPPH, and ABTS radical scavenging activity were detected in an ethyl acetate extract at 50 \u03bcg\/mL concentration. The methanol extract showed the highest antityrosinase effect at 200 \u03bcg\/mL concentration.<\/jats:p>","DOI":"10.3390\/molecules29133017","type":"journal-article","created":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T07:20:06Z","timestamp":1719386406000},"page":"3017","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Antimicrobial, Antioxidant, and Antityrosinase Activities of Morina persica L. and Its Isolated Compounds"],"prefix":"10.3390","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2505-027X","authenticated-orcid":false,"given":"R\u0131dvan","family":"\u00d6zgen","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Botany, Faculty of Pharmacy, Inonu University, 44280 Malatya, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9098-9021","authenticated-orcid":false,"given":"Esen","family":"Sezen Karao\u011flan","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Botany, Faculty of Pharmacy, Ataturk University, 25240 Erzurum, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2738-6874","authenticated-orcid":false,"given":"Handan G\u00f6kben","family":"Sevindik","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy, Ataturk University, 25240 Erzurum, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3644-8531","authenticated-orcid":false,"given":"Hayrunisa","family":"Hanc\u0131","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Ataturk University, 25240 Erzurum, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5249-0895","authenticated-orcid":false,"given":"Cavit","family":"Kazaz","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science, Ataturk University, 25240 Erzurum, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,26]]},"reference":[{"key":"ref_1","first-page":"1","article-title":"Chemical constituents of Morina genus: A comprehensive review","volume":"1","author":"Kumar","year":"2013","journal-title":"Am. J. Essent. Oil. Nat. Prod."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e11121","DOI":"10.1002\/ece3.11121","article-title":"Prediction of potential distributions of Morina kokonorica and Morina chinensis in China","volume":"14","author":"Yuan","year":"2024","journal-title":"Ecol. Evol."},{"key":"ref_3","unstructured":"(2024, May 21). Caprifoliaceae Juss., The World Flora Online. Available online: http:\/\/www.worldfloraonline.org\/taxon\/wfo-7000000112."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.jff.2016.05.010","article-title":"Biological and chemical insights of Morina persica L.: A source of bioactive compounds with multifunctional properties","volume":"25","author":"Mocan","year":"2016","journal-title":"J. Funct. Foods"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1002\/hlca.200800216","article-title":"New triterpenoid saponins and neolignans from Morina kokonorica","volume":"92","author":"Zhu","year":"2009","journal-title":"Helv. Chim. Acta"},{"key":"ref_6","unstructured":"Ozgen, R. (2023). Pharmacognostic Studies on Morina persica L.. [Master\u2019s Thesis, Ataturk University Institute of Health Sciences]."},{"key":"ref_7","unstructured":"Yal\u00e7\u0131n, D. (2023). Ethnobotanical, Morphological and Ecological Characteristics of Morina persica L. (Morinaceae). Science Horizons: Nanotechnology, Plant Diversity, Microbial Insights, and Sustainable Solutions, Bidge Publications. [1st ed.]."},{"key":"ref_8","first-page":"5","article-title":"Ethnobotanical study of some medicinal plants from tehsil BudhaL, District Rajouri, (Jammu and Kashmir)","volume":"2","author":"Shah","year":"2012","journal-title":"Int. Multidiscip. Res. J."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"214121","DOI":"10.1016\/j.ccr.2021.214121","article-title":"Antimicrobial MOFs","volume":"446","author":"Pettinari","year":"2021","journal-title":"Coord. Chem. Rev."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"106103","DOI":"10.1016\/j.ejps.2021.106103","article-title":"Antimicrobial resistance: Prevalence, economic burden, mechanisms of resistance and strategies to overcome","volume":"170","author":"Pulingam","year":"2022","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Halliwell, B., and Gutter\u0131dge, J.M.C. (2015). Free Radicals in Biology and Medicine, Oxford University Press.","DOI":"10.1093\/acprof:oso\/9780198717478.001.0001"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1271\/bbb.69.197","article-title":"Screening for tyrosinase inhibitors among extracts of seashore plants and identification of potent inhibitors from Garcinia subelliptica","volume":"69","author":"Masuda","year":"2005","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"22159","DOI":"10.1039\/D1RA03196A","article-title":"Natural and synthetic flavonoid derivatives as new potential tyrosinase inhibitors: A systematic review","volume":"11","author":"Obaid","year":"2021","journal-title":"RSC Adv."},{"key":"ref_14","first-page":"790","article-title":"Kaempferol and kaempferol glycosides from Phyllanthus acidus leaves","volume":"54","author":"Tram","year":"2016","journal-title":"Vietnam J. Chem."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"6206","DOI":"10.1016\/j.chroma.2011.01.058","article-title":"Separation of patuletin-3-O-glucoside, astragalin, quercetin, kaempferol and isorhamnetin from Flaveria bidentis (L.) Kuntze by elution-pump-out high-performance counter-current chromatography","volume":"1218","author":"Wei","year":"2011","journal-title":"J. Chromatogr. A"},{"key":"ref_16","first-page":"64","article-title":"Isolation and antimicrobial activity of rutin and its derivatives from Ruta chalepensis (Rutaceae) growing in Iraq","volume":"13","author":"Nahar","year":"2019","journal-title":"Rec. Nat. Prod."},{"key":"ref_17","first-page":"1856","article-title":"Isolation and Characterisation of the Antioxidant Phenolic Metabolites of Boerhaavia erecta L. Leaves","volume":"4","author":"Petrus","year":"2012","journal-title":"J. Pharm. Sci. Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1080\/01496395.2013.838968","article-title":"Separation and Purification of Rosmarinic Acid and Rutin from Glechoma hederacea L. using High-Speed Counter-Current Chromatography","volume":"49","author":"Xie","year":"2014","journal-title":"Sep. Sci. Technol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1002\/ptr.1648","article-title":"Evaluation of Antiprotozoal and Plasmodial Enoyl-ACP Reductase Inhibition Potential of Turkish Medicinal Plants","volume":"19","author":"Tasdemir","year":"2005","journal-title":"Phytother. Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.9734\/jpri\/2019\/v26i330138","article-title":"Antimicrobial and Antioxidant Properties of Kaempferol-3-O-glucoside and 1-(4-Hydroxyphenyl)-3-phenylpropan-1-one Isolated from the Leaves of Annona muricata (Linn.)","volume":"26","author":"Taiwo","year":"2019","journal-title":"J. Pharm. Res. Int."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"108483","DOI":"10.1016\/j.carres.2021.108483","article-title":"Isolation, characterization and prediction of biologically active glycoside compounds quercetin-3-rutinoside from the fruits of Ficus sycomorus","volume":"511","author":"Hossain","year":"2022","journal-title":"Carbohydr. Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1007\/s00204-020-02689-3","article-title":"Antioxidants and antioxidant methods: An updated overview","volume":"94","author":"Gulcin","year":"2020","journal-title":"Arch. Toxicol."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"El-Nashar, H.A.S., El-Din, M.I.G., Hritcu, L., and Eldahshan, O.A. (2021). Insights on the Inhibitory Power of Flavonoids on Tyrosinase Activity: A Survey from 2016 to 2021. Molecules, 26.","DOI":"10.3390\/molecules26247546"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"103159","DOI":"10.1016\/j.arabjc.2021.103159","article-title":"Phytochemical profiling and anti-aging activities of Euphorbia retusa extract: In silico and in vitro studies","volume":"14","author":"Elgamal","year":"2021","journal-title":"Arab. J. Chem."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"147","DOI":"10.12928\/pharmaciana.v10i2.13010","article-title":"Antioxidant and antiaging activity of rutin and caffeic acid","volume":"10","author":"Girsang","year":"2020","journal-title":"Pharmaciana"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"G\u00f6zc\u00fc, S., U\u011fan, R.A., \u00d6zbek, H., G\u00fcndo\u011fdu, B., and G\u00fcvenalp, Z. (2024). Evaluation of antidiabetic and antioxidant effects of Polygonum cognatum Meisn. and phytochemical analysis of effective extracts. BMC, 38.","DOI":"10.1002\/bmc.5809"},{"key":"ref_27","unstructured":"(2017). Performance Standards for Antimicrobial Susceptibility Testing, Twenty-Seventh Informational Supplement. Standard No. M100-S27."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0021-9258(18)88697-5","article-title":"On phosphotungstic-phosphomolybdic compounds as colour reagents","volume":"12","author":"Folin","year":"1912","journal-title":"J. Biol. Chem."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"49","DOI":"10.5344\/ajev.1977.28.1.49","article-title":"Total phenol analysis: Automation and comparison with manual methods","volume":"28","author":"Slinkard","year":"1977","journal-title":"Am. J. Enol. Vitic."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1080\/10942910701567364","article-title":"Antioxidant, Antimicrobial, Antifungal, and Antiradical Activities of Cyclotrichium niveum (BOISS.) Manden and Schen","volume":"11","author":"Gulcin","year":"2008","journal-title":"Int. J. Food Prop."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1038\/1811199a0","article-title":"Antioxidant determinations by the use of a stable free radical","volume":"181","author":"Blois","year":"1958","journal-title":"Nature"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/S0891-5849(98)00315-3","article-title":"Antioxidant activity applying an improved ABTS radical cation decolorization assay","volume":"26","author":"Re","year":"1999","journal-title":"Free Radic. Biol. Med."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/29\/13\/3017\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:04:27Z","timestamp":1760108667000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/29\/13\/3017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,26]]},"references-count":32,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2024,7]]}},"alternative-id":["molecules29133017"],"URL":"https:\/\/doi.org\/10.3390\/molecules29133017","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,26]]}}}