{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T23:45:18Z","timestamp":1792453518615,"version":"4.5.0"},"reference-count":128,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T00:00:00Z","timestamp":1719446400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Rehabilitation of fully or partially edentulous patients with dental implants represents one of the most frequently used surgical procedures. The work of Branemark, who observed that a piece of titanium embedded in rabbit bone became firmly attached and difficult to remove, introduced the concept of osseointegration and revolutionized modern dentistry. Since then, an ever-growing need for improved implant materials towards enhanced material\u2013tissue integration has emerged. There is a strong belief that nanoscale materials will produce a superior generation of implants with high efficiency, low cost, and high volume. The aim of this review is to explore the contribution of nanomaterials in implantology. A variety of nanomaterials have been proposed as potential candidates for implant surface customization. They can have inherent antibacterial properties, provide enhanced conditions for osseointegration, or act as reservoirs for biomolecules and drugs. Titania nanotubes alone or in combination with biological agents or drugs are used for enhanced tissue integration in dental implants. Regarding immunomodulation and in order to avoid implant rejection, titania nanotubes, graphene, and biopolymers have successfully been utilized, sometimes loaded with anti-inflammatory agents and extracellular vesicles. Peri-implantitis prevention can be achieved through the inherent antibacterial properties of metal nanoparticles and chitosan or hybrid coatings bearing antibiotic substances. For improved corrosion resistance various materials have been explored. However, even though these modifications have shown promising results, future research is necessary to assess their clinical behavior in humans and proceed to widespread commercialization.<\/jats:p>","DOI":"10.3390\/molecules29133061","type":"journal-article","created":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T08:57:50Z","timestamp":1719478670000},"page":"3061","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Nano-Based Approaches in Surface Modifications of Dental Implants: A Literature Review"],"prefix":"10.3390","volume":"29","author":[{"given":"Chrysa","family":"Marasli","sequence":"first","affiliation":[{"name":"Laboratory of Biology, Department of Basic Medical Sciences, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5741-4288","authenticated-orcid":false,"given":"Hector","family":"Katifelis","sequence":"additional","affiliation":[{"name":"Laboratory of Biology, Department of Basic Medical Sciences, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3295-6811","authenticated-orcid":false,"given":"Maria","family":"Gazouli","sequence":"additional","affiliation":[{"name":"Laboratory of Biology, Department of Basic Medical Sciences, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece"},{"name":"School of Science and Technology, Hellenic Open University, 26335 Patra, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9317-9510","authenticated-orcid":false,"given":"Nefeli","family":"Lagopati","sequence":"additional","affiliation":[{"name":"Laboratory of Biology, Department of Basic Medical Sciences, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece"},{"name":"Biomedical Research Foundation, Academy of Athens, 11527 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1111\/prd.12170","article-title":"Implant placement post extraction in esthetic single tooth sites: When immediate, when early, when late?","volume":"73","author":"Buser","year":"2017","journal-title":"Periodontol. 2000"},{"key":"ref_2","first-page":"81","article-title":"Intra-osseous anchorage of dental prostheses: I. Experimental studies","volume":"3","author":"Branemark","year":"1969","journal-title":"Scand. J. Plast. Reconstr. Surg."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.cden.2014.12.003","article-title":"Implant surface material, design, and osseointegration","volume":"59","author":"Ogle","year":"2015","journal-title":"Dent. Clin. N. Am."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1002\/jbm.b.31264","article-title":"Basic research methods and current trends of dental implant surfaces","volume":"88","author":"Coelho","year":"2009","journal-title":"J. Biomed. Mater. Res. B Appl. Biomater."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"50","DOI":"10.5125\/jkaoms.2014.40.2.50","article-title":"Current trends in dental implants","volume":"40","author":"Gaviria","year":"2014","journal-title":"J. Korean Assoc. Oral Maxillofac. Surg."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1016\/j.biomaterials.2007.11.040","article-title":"Tailoring the surface properties of Ti6Al4V by controlled chemical oxidation","volume":"29","author":"Variola","year":"2008","journal-title":"Biomaterials"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"3822","DOI":"10.1016\/j.biomaterials.2008.05.012","article-title":"Advancing dental implant surface technology--from micron- to nanotopography","volume":"29","author":"Cooper","year":"2008","journal-title":"Biomaterials"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1002\/1097-4636(20000905)51:3<475::AID-JBM23>3.0.CO;2-9","article-title":"Specific proteins mediate enhanced osteoblast adhesion on nanophase ceramics","volume":"51","author":"Webster","year":"2000","journal-title":"J. Biomed. Mater. Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1002\/jbm.a.30789","article-title":"Increased osteoblast and decreased Staphylococcus epidermidis functions on nanophase ZnO and TiO2","volume":"78","author":"Colon","year":"2006","journal-title":"J. Biomed. Mater. Res. A"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1039\/C8BM00021B","article-title":"A review of nanostructured surfaces and materials for dental implants: Surface coating, patterning and functionalization for improved performance","volume":"6","author":"Rasouli","year":"2018","journal-title":"Biomater. Sci."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Valamvanos, T.-F., Dereka, X., Katifelis, H., Gazouli, M., and Lagopati, N. (2024). Recent Advances in Scaffolds for Guided Bone Regeneration. Biomimetics, 9.","DOI":"10.3390\/biomimetics9030153"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"3523","DOI":"10.2147\/IJN.S237008","article-title":"TiO2 Nanotubes Alleviate Diabetes-Induced Osteogenetic Inhibition","volume":"15","author":"Yang","year":"2020","journal-title":"Int. J. Nanomed."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1111\/jre.12707","article-title":"Biomaterial-based possibilities for managing peri-implantitis","volume":"55","year":"2020","journal-title":"J. Periodontal Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"114900","DOI":"10.1016\/j.addr.2023.114900","article-title":"Fit and forget: The future of dental implant therapy via nanotechnology","volume":"199","author":"Gulati","year":"2023","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Kunrath, M.F., Shah, F.A., and Dahlin, C. (2022). Bench-to-bedside: Feasibility of nano-engineered and drug-delivery biomaterials for bone-anchored implants and periodontal applications. Mater. Today Bio, 18.","DOI":"10.1016\/j.mtbio.2022.100540"},{"key":"ref_16","unstructured":"Demetzos, C. (2018). Pharmaceutical Nanotechnology Fundamentals and Practical Applications, Adis."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.actbio.2021.03.027","article-title":"Understanding and optimizing the antibacterial functions of anodized nano-engineered titanium implants","volume":"127","author":"Chopra","year":"2021","journal-title":"Acta Biomater."},{"key":"ref_18","first-page":"1145","article-title":"Improved osseointegration of dental titanium implants by TiO2 nanotube arrays with recombinant human bone morphogenetic protein-2: A pilot in vivo study","volume":"10","author":"Lee","year":"2015","journal-title":"Int. J. Nanomed."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Zhang, Y., Gulati, K., Li, Z., Di, P., and Liu, Y. (2021). Dental Implant Nano-Engineering: Advances, Limitations and Future Directions. Nanomaterials, 11.","DOI":"10.3390\/nano11102489"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/j.msec.2018.05.069","article-title":"An overview of application of silver nanoparticles for biomaterials in dentistry","volume":"91","author":"Bapat","year":"2018","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1002\/aic.10087","article-title":"Nanoscale Science and Engineering: Unifying and Transforming Tools","volume":"50","author":"Roco","year":"2004","journal-title":"AIChE J."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1016\/j.jdent.2015.10.010","article-title":"Anti-biofilm activity of zinc oxide and hydroxyapatite nanoparticles as dental implant coating materials","volume":"43","author":"Abdulkareem","year":"2015","journal-title":"J. Dent."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Vagena, I.-A., Gatou, M.-A., Theocharous, G., Pantelis, P., Gazouli, M., Pippa, N., Gorgoulis, V.G., Pavlatou, E.A., and Lagopati, N. (2024). Functionalized ZnO-Based Nanocomposites for Diverse Biological Applications: Current Trends and Future Perspectives. Nanomaterials, 14.","DOI":"10.3390\/nano14050397"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Huang, Y., Li, P., Zhao, R., Zhao, L., Liu, J., Peng, S., Fu, X., Wang, X., Luo, R., and Wang, R. (2022). Silica nanoparticles: Biomedical applications and toxicity. Biomed. Pharmacother., 151.","DOI":"10.1016\/j.biopha.2022.113053"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Chen, L., Zhou, X., and He, C. (2019). Mesoporous silica nanoparticles for tissue-engineering applications. Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol., 11.","DOI":"10.1002\/wnan.1573"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"50","DOI":"10.2174\/1874210601408010050","article-title":"A brief historical perspective on dental implants, their surface coatings and treatments","volume":"8","author":"Abraham","year":"2014","journal-title":"Open Dent. J."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Choi, A., and Ben-Nissan, B. (2019). Hydroxyapatite Scaffolds Produced from Cuttlefish Bone via Hydrothermal Transformation for Application in Tissue Engineering and Drug Delivery Systems. Marine-Derived Biomaterials for Tissue Engineering Applications, Springer.","DOI":"10.1007\/978-981-13-8855-2"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Almeida, D., Sartoretto, S.C., Calasans-Maia, J.A., Ghiraldini, B., Bezerra, F.J.B., Granjeiro, J.M., and Calasans-Maia, M.D. (2023). In vivo osseointegration evaluation of implants coated with nanostructured hydroxyapatite in low density bone. PLoS ONE, 18.","DOI":"10.1371\/journal.pone.0282067"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1752-248X.2010.01112.x","article-title":"Long-term survivability of hydroxyapatite-coated implants: A meta-analysis","volume":"4","author":"Zhou","year":"2011","journal-title":"Oral Surg."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"5745","DOI":"10.2147\/IJN.S319569","article-title":"Direct-Deposited Graphene Oxide on Dental Implants for Antimicrobial Activities and Osteogenesis","volume":"16","author":"Jang","year":"2021","journal-title":"Int. J. Nanomed."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Di Carlo, R., Di Crescenzo, A., Pilato, S., Ventrella, A., Piattelli, A., Recinella, L., Chiavaroli, A., Giordani, S., Baldrighi, M., and Camisasca, A. (2020). Osteoblastic Differentiation on Graphene Oxide-Functionalized Titanium Surfaces: An In Vitro Study. Nanomaterials, 10.","DOI":"10.3390\/nano10040654"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"L\u00f3pez-Valverde, N., Aragoneses, J., L\u00f3pez-Valverde, A., Rodr\u00edguez, C., Macedo de Sousa, B., and Aragoneses, J.M. (2022). Role of chitosan in titanium coatings. trends and new generations of coatings. Front. Bioeng. Biotechnol., 10.","DOI":"10.3389\/fbioe.2022.907589"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1080\/17425247.2017.1266332","article-title":"Dental implants modified with drug releasing titania nanotubes: Therapeutic potential and developmental challenges","volume":"14","author":"Gulati","year":"2017","journal-title":"Expert Opin. Drug. Deliv."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1002\/jbm.a.31388","article-title":"TiO2 nanotubes functionalized with regions of bone morphogenetic protein-2 increases osteoblast adhesion","volume":"84","author":"Balasundaram","year":"2008","journal-title":"J. Biomed. Mater. Res. A"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2322","DOI":"10.1016\/j.actbio.2009.02.032","article-title":"Bioactivation of titanium surfaces using coatings of TiO(2) nanotubes rapidly pre-loaded with synthetic hydroxyapatite","volume":"5","author":"Kodama","year":"2009","journal-title":"Acta Biomater."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.2147\/IJN.S55514","article-title":"Effects of titania nanotubes with or without bovine serum albumin loaded on human gingival fibroblasts","volume":"9","author":"Liu","year":"2014","journal-title":"Int. J. Nanomed."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1902\/jop.2010.100608","article-title":"Effect of bisphosphonates on anodized and heat-treated titanium surfaces: An animal experimental study","volume":"82","author":"Lee","year":"2011","journal-title":"J. Periodontol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1039\/C5TB01956G","article-title":"Alendronate-loaded hydroxyapatite-TiO2 nanotubes for improved bone formation in osteoporosis rabbits","volume":"4","author":"Shen","year":"2016","journal-title":"J. Mater. Chem. B"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"478","DOI":"10.3899\/jrheum.080759","article-title":"Canadian Taskforce on Osteonecrosis of the Jaw. Bisphosphonate associated osteonecrosis of the jaw","volume":"36","author":"Khan","year":"2009","journal-title":"J. Rheumatol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1016\/j.nano.2014.07.002","article-title":"Vacuum extraction enhances rhPDGF-BB immobilization on nanotubes to improve implant osseointegration in ovariectomized rats","volume":"10","author":"Zhang","year":"2014","journal-title":"Nanomedicine"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"10199","DOI":"10.1016\/j.biomaterials.2013.08.080","article-title":"Bone regeneration around N-acetyl cysteine-loaded nanotube titanium dental implant in rat mandible","volume":"34","author":"Lee","year":"2013","journal-title":"Biomaterials"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"13969","DOI":"10.1016\/j.ceramint.2020.02.195","article-title":"Synergistic effects of lanthanum and strontium to enhance the osteogenic activity of TiO2 nanotube biological interface","volume":"46","author":"Zhang","year":"2020","journal-title":"Ceram. Int."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1111\/joor.12435","article-title":"Dental implants in diabetic patients: Retrospective cohort study reporting on implant survival and risk indicators for excessive marginal bone loss at 5 years","volume":"43","author":"Sabas","year":"2016","journal-title":"J. Oral Rehabil."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1097\/MED.0000000000000482","article-title":"Current status of dental implants survival and peri-implant bone loss in patients with uncontrolled type-2 diabetes mellitus","volume":"26","author":"Chambrone","year":"2019","journal-title":"Curr. Opin. Endocrinol. Diabetes Obes."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1016\/j.nano.2017.02.020","article-title":"Nanoparticle mediated PPAR\u03b3 gene delivery on dental implants improves osseointegration via mitochondrial biogenesis in diabetes mellitus rat model","volume":"13","author":"Lee","year":"2017","journal-title":"Nanomedicine"},{"key":"ref_46","first-page":"4649","article-title":"Immobilization of chitosan film containing semaphorin 3A onto a microarc oxidized titanium implant surface via silane reaction to improve MG63 osteogenic differentiation","volume":"9","author":"Fang","year":"2014","journal-title":"Int. J. Nanomed."},{"key":"ref_47","first-page":"859","article-title":"Bone integration capability of nanopolymorphic crystalline hydroxyapatite coated on titanium implants","volume":"7","author":"Yamada","year":"2012","journal-title":"Int. J. Nanomed."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1111\/j.1600-0501.2011.02362.x","article-title":"Effects of magnesium-substituted nanohydroxyapatite coating on implant osseointegration","volume":"24","author":"Zhao","year":"2013","journal-title":"Clin. Oral Implants Res."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.jcis.2016.02.022","article-title":"Titanium dental implants surface-immobilized with gold nanoparticles as osteoinductive agents for rapid osseointegration","volume":"1","author":"Heo","year":"2016","journal-title":"J. Colloid Interface Sci."},{"key":"ref_50","first-page":"653","article-title":"Ag-plasma modification enhances bone apposition around titanium dental implants: An animal study in Labrador dogs","volume":"10","author":"Qiao","year":"2015","journal-title":"Int. J. Nanomed."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.msec.2018.06.043","article-title":"Biological effect of hydrothermally synthesized silica nanoparticles within crystalline hydroxyapatite coatings for titanium implants","volume":"92","author":"Bartkowiak","year":"2018","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1002\/adma.201704906","article-title":"Diatom-Inspired Silica Nanostructure Coatings with Controllable Microroughness Using an Engineered Mussel Protein Glue to Accelerate Bone Growth on Titanium-Based Implants","volume":"29","author":"Jo","year":"2017","journal-title":"Adv. Mater."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.apsusc.2015.12.022","article-title":"Osseointegration properties of titanium dental implants modified with a nanostructured coating based on ordered porous silica and bioactive glass nanoparticles","volume":"363","author":"Covarrubias","year":"2016","journal-title":"Appl. Surf. Sci."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1002\/cre2.389","article-title":"Implant functionalization with mesoporous silica: A promising antibacterial strategy, but does such an implant osseointegrate?","volume":"7","author":"Vandamme","year":"2021","journal-title":"Clin. Exp. Dent. Res."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Frankenberger, T., Graw, C.L., Engel, N., Gerber, T., Frerich, B., and Dau, M. (2021). Sustainable Surface Modification of Polyetheretherketone (PEEK) Implants by Hydroxyapatite\/Silica Coating-An In Vivo Animal Study. Materials, 14.","DOI":"10.3390\/ma14164589"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1016\/j.msec.2011.07.016","article-title":"Zirconium oxide nanotube surface prompts increased osteoblast functionality and mineralization","volume":"31","author":"Frandsen","year":"2011","journal-title":"Mater. Sci. Eng."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"39470","DOI":"10.1021\/acsami.9b12733","article-title":"Enhanced Osseointegration of Titanium Alloy Implants with Laser Microgrooved Surfaces and Graphene Oxide Coating","volume":"11","author":"Wang","year":"2019","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1055\/s-0040-1713952","article-title":"Role of New Hydrphilic Surfaces on Early Success Rate and Implant Stability: 1-Year Post-loading Results of a Multicenter, Split-Mouth, Randomized Controlled Trial","volume":"15","author":"Tallarico","year":"2021","journal-title":"Eur. J. Dent."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"29","DOI":"10.36130\/CTD.03.2023.04","article-title":"A split-mouth, multicentre randomized controlled trial comparing single sandblasted acidetched implants with or without surface modified with ph buffering agent: Results one year after loading","volume":"5","author":"Tallarico","year":"2023","journal-title":"Clin. Trials Dent."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Zhang, J., Bai, H., Bai, M., Wang, X., Li, Z., Xue, H., Wang, J., Cui, Y., Wang, H., and Wang, Y. (2023). Bisphosphonate-incorporated coatings for orthopedic implants functionalization. Mater. Today Bio, 22.","DOI":"10.1016\/j.mtbio.2023.100737"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1111\/cid.12274","article-title":"Foreign Body Reaction to Biomaterials: On Mechanisms for Buildup and Breakdown of Osseointegration","volume":"18","author":"Trindade","year":"2016","journal-title":"Clin. Implant. Dent. Relat. Res."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"2469","DOI":"10.1007\/s10924-020-01787-8","article-title":"Biocidal Activity of Bone Cements Containing Curcumin and Pegylated Quaternary Polyethylenimine","volume":"28","author":"Eren","year":"2020","journal-title":"J. Polym. Environ."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.jdsr.2021.01.001","article-title":"Osteoimmunology drives dental implant osseointegration: A new paradigm for implant dentistry","volume":"57","year":"2021","journal-title":"Jpn. Dent. Sci. Rev."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.colsurfb.2009.08.039","article-title":"Osteoconductive conjugation of bone morphogenetic protein-2 onto titanium\/titanium oxide surfaces coated with non-biofouling poly(poly(ethylene glycol) methacrylate)","volume":"75","author":"Kang","year":"2010","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1039\/C2BM00079B","article-title":"Reduced in vitro immune response on titania nanotube arrays compared to titanium surface","volume":"1","author":"Smith","year":"2013","journal-title":"Biomater. Sci."},{"key":"ref_66","first-page":"6455","article-title":"Attenuation of the macrophage inflammatory activity by TiO2 nanotubes via inhibition of MAPK and NF-\u03baB pathways","volume":"10","author":"Neacsu","year":"2015","journal-title":"Int. J. Nanomed."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.msec.2018.05.075","article-title":"Titania nanopores with dual micro-\/nano-topography for selective cellular bioactivity","volume":"91","author":"Gulati","year":"2018","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.jmst.2022.12.023","article-title":"Regulation of TiO2 nanoarrays on titanium implants for enhanced osteogenic activity and immunomodulation","volume":"150","author":"Li","year":"2023","journal-title":"J. Mater. Sci. Technol."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Su, J., Du, Z., Xiao, L., Wei, F., Yang, Y., Li, M., Qiu, Y., Liu, J., Chen, J., and Xiao, Y. (2020). Graphene oxide coated Titanium Surfaces with Osteoimmunomodulatory Role to Enhance Osteogenesis. Mater. Sci. Eng. C Mater. Biol. Appl., 113.","DOI":"10.1016\/j.msec.2020.110983"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"126624","DOI":"10.1016\/j.surfcoat.2020.126624","article-title":"Thermo-sensitive hydrogel on anodized titanium surface to regulate immune response","volume":"405","author":"Li","year":"2020","journal-title":"Surf. Coat. Technol."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Chen, D., Yu, C., Ying, Y., Luo, Y., Ren, L., Zhu, C., Yang, K., Wu, B., and Liu, Q. (2022). Study of the Osteoimmunomodulatory Properties of Curcumin-Modified Copper-Bearing Titanium. Molecules, 27.","DOI":"10.3390\/molecules27103205"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"e2307269","DOI":"10.1002\/advs.202307269","article-title":"A Multifunctional Metal-Phenolic Nanocoating on Bone Implants for Enhanced Osseointegration via Early Immunomodulation","volume":"11","author":"Liu","year":"2024","journal-title":"Adv. Sci."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.ijpharm.2015.07.046","article-title":"Use of anodized titanium alloy as drug carrier: Ibuprofen as model of drug releasing","volume":"492","author":"Doadrio","year":"2015","journal-title":"Int. J. Pharm."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Shen, K., Tang, Q., Fang, X., Zhang, C., Zhu, Z., Hou, Y., and Lai, M. (2020). The sustained release of dexamethasone from TiO2 nanotubes reinforced by chitosan to enhance osteoblast function and anti-inflammation activity. Mater. Sci. Eng. C Mater. Biol. Appl., 116.","DOI":"10.1016\/j.msec.2020.111241"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1007\/s40195-019-00926-y","article-title":"Inducing macrophages M2 polarization by dexamethasone laden mesoporous silica nanoparticles from titanium implant surface for enhanced osteogenesis","volume":"32","author":"Luo","year":"2019","journal-title":"Acta Metall. Sin."},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Wei, Y., Liu, Z., Zhu, X., Jiang, L., Shi, W., Wang, Y., Xu, N., Gang, F., Wang, X., and Zhao, L. (2020). Dual directions to address the problem of aseptic loosening via electrospun PLGA @ aspirin nanofiber coatings on titanium. Biomaterials, 257.","DOI":"10.1016\/j.biomaterials.2020.120237"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s10856-022-06697-w","article-title":"Aspirin\/PLGA coated 3D-printed Ti-6Al-4V alloy modulate macrophage polarization to enhance osteoblast differentiation and osseointegration","volume":"33","author":"You","year":"2022","journal-title":"J. Mater. Sci. Mater. Med."},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Zhao, Q., Zhang, Y., Xiao, L., Lu, H., Ma, Y., Liu, Q., and Wang, X. (2021). Surface engineering of titania nanotubes incorporated with double-layered extracellular vesicles to modulate inflammation and osteogenesis. Regen. Biomater., 8.","DOI":"10.1093\/rb\/rbab010"},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Jayasree, A., Liu, C., Salomon, C., Ivanovski, S., Gulati, K., and Han, P. (2023). Microvesicle-eluting nano-engineered implants influence inflammatory response of keratinocytes. Drug. Deliv. Transl. Res., online ahead of print.","DOI":"10.1007\/s13346-023-01457-x"},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Silva, R.C.S., Agrelli, A., Andrade, A.N., Mendes-Marques, C.L., Arruda, I.R.S., Santos, L.R.L., Vasconcelos, N.F., and Machado, G. (2022). Titanium Dental Implants: An Overview of Applied Nanobiotechnology to Improve Biocompatibility and Prevent Infections. Materials, 15.","DOI":"10.3390\/ma15093150"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1002\/JPER.16-0350","article-title":"Peri-implantitis","volume":"89","author":"Schwarz","year":"2018","journal-title":"J. Periodontol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1111\/jcpe.12957","article-title":"Peri-implant diseases and conditions: Consensus report of workgroup 4 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions","volume":"45","author":"Berglundh","year":"2018","journal-title":"J. Clin. Periodontol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1111\/jcpe.12535","article-title":"Peri-implantitis\u2014Onset and pattern of progression","volume":"43","author":"Derks","year":"2016","journal-title":"J. Clin. Periodontol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/prd.12407","article-title":"It is all about peri-implant tissue health","volume":"88","author":"Schwarz","year":"2022","journal-title":"Periodontol. 2000"},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Moraes, G., Zambom, C., and Siqueira, W.L. (2021). Nanoparticles in Dentistry: A Comprehensive Review. Pharmaceuticals, 14.","DOI":"10.3390\/ph14080752"},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Barabadi, H., Mostafavi, E., and Saravanan, M. (2022). Hybrid Multifunctional Nanomaterials for Diagnostic and Therapeutic Applications. Pharmaceutical Nanobiotechnology for Targeted Therapy, Springer. [1st ed.]. Nanotechnology in the Life Sciences.","DOI":"10.1007\/978-3-031-12658-1"},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Lagopati, N., Pippa, N., Gatou, M.-A., Papadopoulou-Fermeli, N., Gorgoulis, V.G., Gazouli, M., and Pavlatou, E.A. (2023). Marine-Originated Materials and Their Potential Use in Biomedicine. Appl. Sci., 13.","DOI":"10.3390\/app13169172"},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Gatou, M.-A., Skylla, E., Dourou, P., Pippa, N., Gazouli, M., Lagopati, N., and Pavlatou, E.A. (2024). Magnesium Oxide (MgO) Nanoparticles: Synthetic Strategies and Biomedical Applications. Crystals, 14.","DOI":"10.3390\/cryst14030215"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1016\/j.biomaterials.2009.09.081","article-title":"The relationship between the nanostructure of titanium surfaces and bacterial attachment","volume":"31","author":"Puckett","year":"2010","journal-title":"Biomaterials"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.biomaterials.2010.09.066","article-title":"Biological actions of silver nanoparticles embedded in titanium controlled by micro-galvanic effects","volume":"32","author":"Cao","year":"2011","journal-title":"Biomaterials"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"6659","DOI":"10.2147\/IJN.S92110","article-title":"Hierarchical micro\/nanostructured titanium with balanced actions to bacterial and mammalian cells for dental implants","volume":"10","author":"Zhu","year":"2015","journal-title":"Int. J. Nanomed."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"4709","DOI":"10.2147\/IJN.S197782","article-title":"Investigation of silver nanoparticles on titanium surface created by ion implantation technology","volume":"14","author":"Beke","year":"2019","journal-title":"Int. J. Nanomed."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.msec.2016.08.059","article-title":"Laser fabrication of Ag-HA nanocomposites on Ti6Al4V implant for enhancing bioactivity and antibacterial capability","volume":"70","author":"Liu","year":"2017","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1002\/jbm.b.33376","article-title":"Antimicrobial effect and biocompatibility of novel metallic nanocrystalline implant coatings","volume":"104","author":"Gosau","year":"2016","journal-title":"J. Biomed. Mater. Res. B Appl. Biomater."},{"key":"ref_95","first-page":"1157","article-title":"Evaluation of antibacterial properties of copper nanoparticles surface coating on titanium dental implant","volume":"10","author":"Hameed","year":"2018","journal-title":"J. Pharm. Sci. Res."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.colsurfb.2015.06.047","article-title":"Surface modification of zirconia with polydopamine to enhance fibroblast response and decrease bacterial activity in vitro: A potential technique for soft tissue engineering applications","volume":"136","author":"Liu","year":"2015","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"5706","DOI":"10.1016\/j.biomaterials.2011.04.040","article-title":"Antibacterial nano-structured titania coating incorporated with silver nanoparticles","volume":"32","author":"Zhao","year":"2011","journal-title":"Biomaterials"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"3467","DOI":"10.1016\/j.biomaterials.2013.01.071","article-title":"Osteogenic activity and antibacterial effects on titanium surfaces modified with Zn-incorporated nanotube arrays","volume":"34","author":"Huo","year":"2013","journal-title":"Biomaterials"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"4465","DOI":"10.1038\/s41467-020-18267-1","article-title":"Graphdiyne-modified TiO2 nanofibers with osteoinductive and enhanced photocatalytic antibacterial activities to prevent implant infection","volume":"11","author":"Wang","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.actbio.2011.09.004","article-title":"Biocompatible polymer coating of titania nanotube arrays for improved drug elution and osteoblast adhesion","volume":"8","author":"Gulati","year":"2012","journal-title":"Acta Biomater."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.colsurfb.2015.04.021","article-title":"Advanced biopolymer-coated drug-releasing titania nanotubes (TNTs) implants with simultaneously enhanced osteoblast adhesion and antibacterial properties","volume":"130","author":"Kumeria","year":"2015","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.jddst.2018.09.008","article-title":"Nano spray drying: A novel technique to prepare well-defined surface coatings for medical implants","volume":"48","author":"Baghdan","year":"2018","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1002\/jbm.a.33251","article-title":"Local delivery of antimicrobial peptides using self-organized TiO2 nanotube arrays for peri-implant infections","volume":"100","author":"Ma","year":"2012","journal-title":"J. Biomed. Mater. Res. A"},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Srivastava, M.G., Kamarudin, N.H.N., Aktan, M.K., Zheng, K., Zayed, N., Yongabi, D., Wagner, P., Teughels, W., Boccaccini, A.R., and Braem, A. (2024). pH-Triggered Controlled Release of Chlorhexidine Using Chitosan-Coated Titanium Silica Composite for Dental Infection Prevention. Pharmaceutics, 16.","DOI":"10.3390\/pharmaceutics16030377"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.msec.2019.01.019","article-title":"Deposition of catechol-functionalized chitosan and silver nanoparticles on biomedical titanium surfaces for antibacterial application","volume":"98","author":"Cheng","year":"2019","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.carbpol.2014.12.027","article-title":"Mechanically stable antimicrobial chitosan-PVA-silver nanocomposite coatings deposited on titanium implants","volume":"121","author":"Mishra","year":"2015","journal-title":"Carbohydr. Polym."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"13785","DOI":"10.1021\/acsami.6b03454","article-title":"Electrophoretic deposition of chitosan coatings modified with gelatin nanospheres to tune the release of antibiotics","volume":"8","author":"Song","year":"2016","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Choi, S.H., Jang, Y.S., Jang, J.H., Bae, T.S., Lee, S.J., and Lee, M.H. (2019). Enhanced antibacterial activity of titanium by surface modification with polydopamine and silver for dental implant application. J. Appl. Biomater. Funct. Mater., 17.","DOI":"10.1177\/2280800019847067"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.carbpol.2018.09.064","article-title":"Synthesis and characterization of silica-chitosan hybrid materials as antibacterial coatings for titanium implants","volume":"203","author":"Rojo","year":"2019","journal-title":"Carbohydr. Polym."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.msec.2016.08.050","article-title":"Reduced bacteria adhesion on octenidine loaded mesoporous silica nanoparticles coating on titanium substrates","volume":"70","author":"Xu","year":"2017","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.msec.2017.02.160","article-title":"Construction of N-halamine labeled silica\/zinc oxide hybrid nanoparticles for enhancing antibacterial ability of Ti implants","volume":"76","author":"Li","year":"2017","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1080\/08927014.2014.983093","article-title":"A graphene\/zinc oxide nanocomposite film protects dental implant surfaces against cariogenic Streptococcus mutans","volume":"30","author":"Kulshrestha","year":"2014","journal-title":"Biofouling"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.colsurfb.2017.07.007","article-title":"Liposome-modified titanium surface: A strategy to locally deliver bioactive molecules","volume":"158","author":"Cimmarusti","year":"2017","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s40496-022-00306-z","article-title":"Insight Into Corrosion of Dental Implants: From Biochemical Mechanisms to Designing Corrosion-Resistant Materials","volume":"9","author":"Nagay","year":"2022","journal-title":"Curr. Oral Health Rep."},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"Guo, T., Scimeca, J.C., Ivanovski, S., Verron, E., and Gulati, K. (2023). Enhanced Corrosion Resistance and Local Therapy from Nano-Engineered Titanium Dental Implants. Pharmaceutics, 15.","DOI":"10.3390\/pharmaceutics15020315"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1177\/0885328213516821","article-title":"In-vitro biocompatibility and corrosion resistance of strontium incorporated TiO2 nanotube arrays for orthopaedic applications","volume":"29","author":"Indira","year":"2014","journal-title":"J. Biomater. Appl."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"012060","DOI":"10.1088\/1757-899X\/870\/1\/012060","article-title":"Improvement the corrosion Behavior of Titanium by Nanotubular Oxide in a simulated saliva solution","volume":"870","author":"Rushdi","year":"2020","journal-title":"IOP Conf. Ser. Mater. Sci. Eng."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/s40204-021-00169-0","article-title":"Effect of titanium dioxide intermediate layer on scratch and corrosion resistance of sol-gel-derived HA coating applied on Ti-6Al-4V substrate","volume":"10","author":"Azari","year":"2021","journal-title":"Prog. Biomater."},{"key":"ref_119","doi-asserted-by":"crossref","unstructured":"Shen, Y., Fang, K., Xiang, Y., Xu, K., Yu, L., Chen, J., Ma, P., Cai, K., Shen, X., and Liu, J. (2022). Improvement in osteogenesis, vascularization, and corrosion resistance of titanium with silicon-nitride doped micro-arc oxidation coatings. Front. Bioeng. Biotechnol., 10.","DOI":"10.3389\/fbioe.2022.1023032"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"3974","DOI":"10.1557\/s43578-021-00277-4","article-title":"Biotribocorrosion of 3D-Printed silica-coated Ti6Al4V for load-bearing implants","volume":"36","author":"Afrouzian","year":"2021","journal-title":"J. Mater. Res."},{"key":"ref_121","doi-asserted-by":"crossref","unstructured":"Hsu, S.M., Fares, C., Xia, X., Rasel, M.A.J., Ketter, J., Afonso Camargo, S.E., Haque, M.A., Ren, F., and Esquivel-Upshaw, J.F. (2021). In Vitro Corrosion of SiC-Coated Anodized Ti Nano-Tubular Surfaces. J. Funct. Biomater., 12.","DOI":"10.3390\/jfb12030052"},{"key":"ref_122","doi-asserted-by":"crossref","unstructured":"Harb, S.V., Bassous, N.J., de Souza, T.A.C., Trentin, A., Pulcinelli, S.H., Santilli, C.V., Webster, T.J., Lobo, A.O., and Hammer, P. (2020). Hydroxyapatite and \u03b2-TCP modified PMMA-TiO2 and PMMA-ZrO2 coatings for bioactive corrosion protection of Ti6Al4V implants. Mater. Sci. Eng. C Mater. Biol. Appl., 116.","DOI":"10.1016\/j.msec.2020.111149"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"126044","DOI":"10.1016\/j.surfcoat.2020.126044","article-title":"Investigation on the corrosion behavior and biocompatibility of Ti-6Al-4V implant coated with HA\/TiN dual layer for medical applications","volume":"397","author":"Kazemi","year":"2020","journal-title":"Surf. Coat. Technol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"130569","DOI":"10.1016\/j.molstruc.2021.130569","article-title":"Antimicrobial properties and corrosion behavior of TiO2-NTs electrodes modified with Ag and ZnO nanorod in simulated body fluid solution","volume":"1240","author":"Aydin","year":"2021","journal-title":"J. Mol. Struct."},{"key":"ref_125","first-page":"377","article-title":"Enhanced physicochemical and biological properties of C\/Cu dual ions implanted medical titanium","volume":"5","author":"Xia","year":"2020","journal-title":"Bioact. Mater."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.apsusc.2008.06.116","article-title":"Enhanced corrosion resistance of Zr coating on biomedical TiNi alloy prepared by plasma immersion ion implantation and deposition","volume":"255","author":"Zheng","year":"2008","journal-title":"Appl. Surf. Sci."},{"key":"ref_127","doi-asserted-by":"crossref","unstructured":"Yusuf, D., Maryani, E., Mardhian, D.F., and Noviyanti, A.R. (2023). Evaluation of Structural Stability, Mechanical Properties, and Corrosion Resistance of Magnesia Partially Stabilized Zirconia (Mg-PSZ). Molecules, 28.","DOI":"10.3390\/molecules28166054"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1038\/s41598-024-52057-9","article-title":"Synergetic effect of essential oils and calcium phosphate nanoparticles for enhancement the corrosion resistance of titanium dental implant","volume":"14","author":"Zaher","year":"2024","journal-title":"Sci. Rep."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/29\/13\/3061\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:06:18Z","timestamp":1760108778000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/29\/13\/3061"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,27]]},"references-count":128,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2024,7]]}},"alternative-id":["molecules29133061"],"URL":"https:\/\/doi.org\/10.3390\/molecules29133061","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,27]]}}}