{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:12:59Z","timestamp":1760145179890,"version":"build-2065373602"},"reference-count":52,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T00:00:00Z","timestamp":1719446400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005969","name":"Alma Mater Studiorum-Universit\u00e0 di Bologna","doi-asserted-by":"publisher","award":["RFO 23"],"award-info":[{"award-number":["RFO 23"]}],"id":[{"id":"10.13039\/501100005969","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Reaction of [Ru(H)2(CO)(PPh3)3] 1 with an equimolar amount of pyrrole-2-carboxylic acid (H2L1) leads to the homoleptic chelate derivative k2(O,O)-[RuH(CO)(HL1)(PPh3)2] 2. Prolonged acetonitrile refluxing promotes an unusual k2(O,O)- \u2192 k2(N,O)- dynamic chelate conversion, forming a neutral, stable, air- and moisture- insensitive, solvento-species k2(N,O)-[Ru(MeCN)(CO)(L1)(PPh3)2] 3. Analogously, reaction of 1 with the pyrrole-2-carboxyaldehyde (HL2) affords k2(N,O)-[RuH(CO)(HL2)(PPh3)2] 4, 5, as a couple of functional isomers. Optimized reaction conditions such as temperature and solvent polarity allow the isolation of dominant configurations. Structure 5 is a pyrrolide Ru-carbaldehyde, obtained from cyclization of the pendant CHO function, whereas species 4 can be viewed as an ethanoyl-conjugated Ru-pyrrole. Derivatives 3\u20135 were characterized by single crystal X-ray diffraction, ESI-Ms, IR, and NMR spectroscopy, indicating distinct features for the Ru-bonded pyrrolyl groups. DFT computational results, coplanarity, bond equalization, and electron delocalization along the fused five-membered rings support aromatic features. In accordance with the antisymbiotic trans-influence, both the isolated isomers 4 and 5 disclose CO ligands opposite to N- or O-anionic groups. The quantitative Mayer bond order evidences a stabilizing backbonding effect. Antibacterial and antifungal trials on Gram-positive (Staphylococcus aureus), Gram-negative (Escherichia coli), and Candida albicans were further carried out.<\/jats:p>","DOI":"10.3390\/molecules29133068","type":"journal-article","created":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T08:57:50Z","timestamp":1719478670000},"page":"3068","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Unpredictable Dynamic Behaviour of Ruthenium Chelate Pyrrole Derivatives"],"prefix":"10.3390","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-2637-1920","authenticated-orcid":false,"given":"Giacomo","family":"Drius","sequence":"first","affiliation":[{"name":"Department of Industrial Chemistry \u2018Toso Montanari\u2019, Alma Mater Studiorum, Universit\u00e0 di Bologna, Via Piero Gobetti, 85, 40129 Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6439-9979","authenticated-orcid":false,"given":"Riccardo","family":"Tarroni","sequence":"additional","affiliation":[{"name":"Department of Industrial Chemistry \u2018Toso Montanari\u2019, Alma Mater Studiorum, Universit\u00e0 di Bologna, Via Piero Gobetti, 85, 40129 Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matteo","family":"Birchmeier","sequence":"additional","affiliation":[{"name":"Department of Industrial Chemistry \u2018Toso Montanari\u2019, Alma Mater Studiorum, Universit\u00e0 di Bologna, Via Piero Gobetti, 85, 40129 Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1536-9276","authenticated-orcid":false,"given":"Carola","family":"Parolin","sequence":"additional","affiliation":[{"name":"Department of Pharmacy and Biotechnology, University of Bologna, 40127 Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2851-8939","authenticated-orcid":false,"given":"Carla","family":"Boga","sequence":"additional","affiliation":[{"name":"Department of Industrial Chemistry \u2018Toso Montanari\u2019, Alma Mater Studiorum, Universit\u00e0 di Bologna, Via Piero Gobetti, 85, 40129 Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2766-7625","authenticated-orcid":false,"given":"Magda","family":"Monari","sequence":"additional","affiliation":[{"name":"Department of Chemistry \u2018Giacomo Ciamician\u2019, Alma Mater Studiorum, Universit\u00e0 di Bologna, Via Selmi 2, 40126 Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2338-7557","authenticated-orcid":false,"given":"Silvia","family":"Bordoni","sequence":"additional","affiliation":[{"name":"Department of Industrial Chemistry \u2018Toso Montanari\u2019, Alma Mater Studiorum, Universit\u00e0 di Bologna, Via Piero Gobetti, 85, 40129 Bologna, Italy"},{"name":"Health Sciences and Technologies Interdepartmental Centre for Industrial Research (CIRI SDV), University of Bologna, 40126 Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"5845","DOI":"10.1021\/jm4017625","article-title":"Rings in Drugs","volume":"57","author":"Taylor","year":"2014","journal-title":"J. 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