{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T14:42:57Z","timestamp":1788273777918,"version":"build-2803163510"},"reference-count":29,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T00:00:00Z","timestamp":1720483200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Science Committee of the Ministry of Science and Higher Education of the Republic of Kazakhstan","award":["AP19674667"],"award-info":[{"award-number":["AP19674667"]}]},{"name":"Belarusian State Scientific Research Program \u201cConvergence 2025\u201d","award":["AP19674667"],"award-info":[{"award-number":["AP19674667"]}]},{"name":"National Academy of Sciences of Belarus","award":["AP19674667"],"award-info":[{"award-number":["AP19674667"]}]},{"name":"KAUST baseline funding","award":["AP19674667"],"award-info":[{"award-number":["AP19674667"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Alkaloid-based urea derivatives were produced with high yield through the reaction of anabasine and cytisine with isoxazolylphenylcarbamates in boiling benzene. Their antitumor activity, in combination with the commonly used five anticancer drugs, namely cyclophosphane, fluorouracil, etoposide, cisplatin, ribomustine with different mechanisms of action, was investigated. Based on the quantum chemical calculations data and molecular docking, hypotheses have been put forward to explain their mutual influence when affecting C6 rat glioma model cells.<\/jats:p>","DOI":"10.3390\/molecules29143246","type":"journal-article","created":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T13:22:36Z","timestamp":1720531356000},"page":"3246","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Alkaloid-Based Isoxazolylureas: Synthesis and Effect in Combination with Anticancer Drugs on C6 Rat Glioma Model Cells"],"prefix":"10.3390","volume":"29","author":[{"given":"Gulim K.","family":"Mukusheva","sequence":"first","affiliation":[{"name":"Faculty of Chemistry, Karaganda Buketov University, Karaganda 100024, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9937-275X","authenticated-orcid":false,"given":"Roza I.","family":"Jalmakhanbetova","sequence":"additional","affiliation":[{"name":"Faculty of Natural Sciences, L.N. 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