{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T02:30:49Z","timestamp":1788489049447,"version":"build-2803163510"},"reference-count":180,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T00:00:00Z","timestamp":1721692800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"STRIKE project HORIZON-MSCA-2021-DN-01","award":["101072462"],"award-info":[{"award-number":["101072462"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Since the discovery of cisplatin\u2019s antitumoral activity and its approval as an anticancer drug, significant efforts have been made to enhance its physiological stability and anticancer efficacy and to reduce its side effects. With the rapid development of targeted and personalized therapies, and the promising theranostic approach, platinum drugs have found new opportunities in more sophisticated systems. Theranostic agents combine diagnostic and therapeutic moieties in one scaffold, enabling simultaneous disease monitoring, therapy delivery, response tracking, and treatment efficacy evaluation. In these systems, the platinum core serves as the therapeutic agent, while the functionalized ligand provides diagnostic tools using various imaging techniques. This review aims to highlight the significant role of platinum\u2013based complexes in theranostic applications, and, to the best of our knowledge, this is the first focused contribution on this type of platinum compounds. This review presents a brief introduction to the development of platinum chemotherapeutic drugs, their limitations, and resistance mechanisms. It then describes recent advancements in integrating platinum complexes with diagnostic agents for both tumor treatment and monitoring. The main body is organized into three categories based on imaging techniques: fluorescence, positron emission tomography (PET), single\u2013photon emission computed tomography (SPECT), and magnetic resonance imaging (MRI). Finally, this review outlines promising strategies and future perspectives in this evolving field.<\/jats:p>","DOI":"10.3390\/molecules29153453","type":"journal-article","created":{"date-parts":[[2024,7,24]],"date-time":"2024-07-24T08:47:17Z","timestamp":1721810837000},"page":"3453","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Recent Advances on Pt-Based Compounds for Theranostic Applications"],"prefix":"10.3390","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-2516-437X","authenticated-orcid":false,"given":"Giulia","family":"Ferrari","sequence":"first","affiliation":[{"name":"Department of Chemistry, Maynooth University, W23 F2H6 Maynooth, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9057-6047","authenticated-orcid":false,"given":"Ines","family":"Lopez-Martinez","sequence":"additional","affiliation":[{"name":"Division of Nuclear Medicine, Department of Biomedical Imaging and Image\u2013Guided Therapy, Medical University of Vienna, 1090 Vienna, Austria"},{"name":"Preclinical Imaging Lab (PIL), Department of Biomedical Imaging and Image\u2013Guided Therapy, Medical University of Vienna, 1090 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0404-4452","authenticated-orcid":false,"given":"Thomas","family":"Wanek","sequence":"additional","affiliation":[{"name":"Preclinical Imaging Lab (PIL), Department of Biomedical Imaging and Image\u2013Guided Therapy, Medical University of Vienna, 1090 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5988-1434","authenticated-orcid":false,"given":"Claudia","family":"Kuntner","sequence":"additional","affiliation":[{"name":"Preclinical Imaging Lab (PIL), Department of Biomedical Imaging and Image\u2013Guided Therapy, Medical University of Vienna, 1090 Vienna, Austria"},{"name":"Medical Imaging Cluster (MIC), Medical University of Vienna, 1090 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1034-9623","authenticated-orcid":false,"given":"Diego","family":"Montagner","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Maynooth University, W23 F2H6 Maynooth, Ireland"},{"name":"Kathleen Londsdale Institute for Human Health Research, Maynooth University, W23 F2H6 Maynooth, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Peng, K., Liang, B.B., Liu, W., and Mao, Z.W. (2021). What Blocks More Anticancer Platinum Complexes from Experiment to Clinic: Major Problems and Potential Strategies from Drug Design Perspectives. Coord. Chem. Rev., 449.","DOI":"10.1016\/j.ccr.2021.214210"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.jinorgbio.2018.11.008","article-title":"Multi\u2013Action Pt(IV) Anticancer Agents; Do We Understand How They Work?","volume":"191","author":"Gibson","year":"2019","journal-title":"J. Inorg. Biochem."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"8113","DOI":"10.1039\/c0dt00292e","article-title":"The Status of Platinum Anticancer Drugs in the Clinic and in Clinical Trials","volume":"39","author":"Wheate","year":"2010","journal-title":"Dalton Trans."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s00775-014-1214-6","article-title":"Comparative In Vitro and In Vivo Pharmacological Investigation of Platinum(IV) Complexes as Novel Anticancer Drug Candidates for Oral Application","volume":"20","author":"Theiner","year":"2015","journal-title":"J. Biol. Inorg. Chem."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.lungcan.2014.04.005","article-title":"Copper Transporter CTR1 Expression and Tissue Platinum Concentration in Non-Small Cell Lung Cancer","volume":"85","author":"Kim","year":"2014","journal-title":"Lung Cancer"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"462","DOI":"10.2174\/0929867324666171110141311","article-title":"Monitoring Interactions Inside Cells by Advanced Spectroscopies: Overview of Copper Transporters and Cisplatin","volume":"25","author":"Lasorsa","year":"2018","journal-title":"Curr. Med. Chem."},{"key":"ref_7","first-page":"5853","article-title":"Increase in Expression of the Copper Transporter ATP7A during Platinum Drug-Based Treatment Is Associated with Poor Survival in Ovarian Cancer Patients","volume":"9","author":"Samimi","year":"2003","journal-title":"Clin. Cancer Res."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"4661","DOI":"10.1158\/1078-0432.CCR-04-0137","article-title":"Increased Expression of the Copper Efflux Transporter ATP7A Mediates Resistance to Cisplatin, Carboplatin, and Oxaliplatin in Ovarian Cancer Cells","volume":"10","author":"Samimi","year":"2004","journal-title":"Clin. Cancer Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1002\/(SICI)1097-0215(19990730)82:3<405::AID-IJC14>3.0.CO;2-M","article-title":"Co-Expression of Gamma-Glutamylcysteine Synthetase Sub-Units in Response to Cisplatin and Doxorubicin in Human Cancer Cells","volume":"82","author":"Iida","year":"1999","journal-title":"Int. J. Cancer."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1080\/10715769900301121","article-title":"Overexpression of Glutathione S-Transferase \u03c0 Enhances the Adduct Formation of Cisplatin with Glutathione in Human Cancer Cells","volume":"31","author":"Goto","year":"1999","journal-title":"Free Rad. Res."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/BF00757625","article-title":"Positive Correlation between Cellular Glutathione and Acquired Cisplatin Resistance in Human Ovarian Cancer Cells","volume":"11","author":"Chen","year":"1995","journal-title":"Cell Biol. Toxicol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/nrd1691","article-title":"Cellular Processing of Platinum Anticancer Drugs","volume":"4","author":"Wang","year":"2005","journal-title":"Nat. Rev. Durg Discov."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/nrc2167","article-title":"The Resurgence of Platinum-Based Cancer Chemotherapy","volume":"7","author":"Kelland","year":"2007","journal-title":"Nat. Rev. Cancer"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1007\/s00280-016-2976-z","article-title":"Platinum\u2013Based Drugs: Past, Present and Future","volume":"77","author":"Dilruba","year":"2016","journal-title":"Cancer Chemother. Pharmacol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1124\/mol.104.001198","article-title":"The Copper Influx Transporter Human Copper Transport Protein 1 Regulates the Uptake of Cisplatin in Human Ovarian Carcinoma Cells","volume":"66","author":"Holzer","year":"2004","journal-title":"Mol. Pharmacol."},{"key":"ref_16","first-page":"987","article-title":"Copper Efflux Transporter (ATP7B) Contributes to the acquisition of Cisplatin-Resistance in Human Oral Squamous Cell Lines","volume":"18","author":"Yoshizawa","year":"2007","journal-title":"Oncol. Rep."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1158\/1078-0432.CCR-03-0454","article-title":"Prognostic Value of the Cu-Transporting ATPase in Ovarian Carcinoma Patients Receiving Cisplatin-Based Chemotherapy","volume":"10","author":"Nakayama","year":"2004","journal-title":"Clin. Cancer Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1245\/s10434-010-1414-4","article-title":"Evaluation of ERCC1 Expression for Cisplatin Sensitivity in Human Hepatocellular Carcinoma","volume":"18","author":"Ueda","year":"2011","journal-title":"Ann. Surg. Oncol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1002\/1097-0215(20000920)89:5<453::AID-IJC9>3.0.CO;2-E","article-title":"ERCC1 Expression as a Molecular Marker of Cisplatin Resistance in Human Cervical Tumor Cells","volume":"89","author":"Britten","year":"2000","journal-title":"Int. J. Cancer"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1111\/IGC.0b013e3181a12e09","article-title":"The Relationship of Platinum Resistance and ERCC1 Protein Expression in Epithelial Ovarian Cancer","volume":"19","author":"Steffensen","year":"2009","journal-title":"Int. J. Gynecol. Cancer"},{"key":"ref_21","first-page":"207","article-title":"ERCC1 and RRM1 as a Predictive Parameter for Non-Small Cell Lung, Ovarian or Pancreas Cancer Treated with Cisplatin and\/or Gemcitabine","volume":"19","author":"Ulker","year":"2015","journal-title":"Contemp. Oncol."},{"key":"ref_22","first-page":"4368","article-title":"Reduced MLH1 Expression after Chemotherapy Is an Indicator for Poor Prognosis in Esophageal Cancers","volume":"9","author":"Kishi","year":"2003","journal-title":"Clin. Cancer Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"5505","DOI":"10.21873\/anticanres.13743","article-title":"MLH1 Is a Prognostic Biomarker for Serous Ovarian Cancer Treated with Platinum- and Taxane-Based Chemotherapy","volume":"39","author":"Kawashima","year":"2019","journal-title":"Anticancer Res."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Chavez\u2013Dominguez, R.L., Perez\u2013Medina, M.A., Lopez\u2013Gonzalez, J.S., Galicia\u2013Velasco, M., Matias\u2013Florentino, M., Avila\u2013Rios, S., Rumbo\u2013Nava, U., Salgado\u2013Aguayo, A., Gonzalez\u2013Gonzalez, C., and Aguilar\u2013Cazares, D. (2021). Role of HMGB1 in Cisplatin-Persistent Lung Adenocarcinoma Cell Lines. Front. Oncol., 11.","DOI":"10.3389\/fonc.2021.750677"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"488","DOI":"10.3892\/mmr.2016.6003","article-title":"Inhibiting the Cytoplasmic Location of HMGB1 Reverses Cisplatin Resistance in Human Cervical Cancer Cells","volume":"15","author":"Xia","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s41065-023-00294-9","article-title":"Elevated HMGB1 Promotes the Malignant Progression and Contributes to Cisplatin Resistance of Non-Small Cell Lung Cancer","volume":"160","author":"Ma","year":"2023","journal-title":"Hereditas"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Nishiguchi, Y., Oue, N., Fujiwara\u2013Tani, R., Sasaki, T., Ohmori, H., Kishi, S., Mori, S., Mori, T., Ikeda, N., and Matsumoto, S. (2020). Role of Metastasis-Related Genes in Cisplatin Chemoresistance in Gastric Cancer. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21010254"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Timmerman, D.M., Eleveld, T.F., Gillis, A.J.M., Friedrichs, C.C., Hillenius, S., Remmers, T.L., Sriram, S., and Looijenga, L.H.J. (2021). The Role of Tp53 in Cisplatin Resistance in Mediastinal and Testicular Germ Cell Tumors. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms222111774"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2584","DOI":"10.1038\/sj.emboj.7601127","article-title":"Apoptosis Regulation in Tetraploid Cancer Cells","volume":"25","author":"Castedo","year":"2006","journal-title":"EMBO J."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1016\/j.jtho.2016.02.002","article-title":"Prognostic and Predictive Effect of TP53 Mutations in Patients with Non-Small Cell Lung Cancer from Adjuvant Cisplatin-Based Therapy Randomized Trials: A LACE-Bio Pooled Analysis","volume":"11","author":"Ma","year":"2016","journal-title":"J. Thorac. Oncol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"12291","DOI":"10.1038\/srep12291","article-title":"Hypoxia-Induced Autophagy Mediates Cisplatin Resistance in Lung Cancer Cells","volume":"5","author":"Wu","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"17163","DOI":"10.1074\/jbc.M114.558288","article-title":"Role of Autophagy in Cisplatin Resistance in Ovarian Cancer Cells","volume":"289","author":"Wang","year":"2014","journal-title":"J. Biol. Chem."},{"key":"ref_33","first-page":"75","article-title":"Acquired Cisplatin Resistance in Human Lung Adenocarcinoma Cells Is Associated with Enhanced Autophagy","volume":"25","author":"Ren","year":"2010","journal-title":"Cancer Biother. Radiophar."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"20502","DOI":"10.1038\/srep20502","article-title":"Cisplatin Resistance in Gastric Cancer Cells Is Associated with HER2 Upregulation-Induced Epithelial-Mesenchymal Transition","volume":"6","author":"Huang","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1186\/1756-9966-28-97","article-title":"The Effect of HER2 Expression on Cisplatin-Based Chemotherapy in Advanced Non-Small Cell Lung Cancer Patients","volume":"28","author":"Calikusu","year":"2009","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"12983","DOI":"10.1039\/C6DT01414C","article-title":"Platinum(IV) Anticancer Prodrugs-Hypotheses and Facts","volume":"45","author":"Gibson","year":"2016","journal-title":"Dalton Trans."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"12","DOI":"10.4143\/crt.2009.41.1.12","article-title":"Randomized, Multicenter, Phase III Trial of Heptaplatin 1-Hour Infusion and 5-Fluorouracil Combination Chemotherapy Comparing with Cisplatin and 5-Fluorouracil Combination Chemotherapy in Patients with Advanced Gastric Cancer","volume":"41","author":"Lee","year":"2009","journal-title":"Cancer Res. Treat."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1517\/13543784.10.1.119","article-title":"Lobaplatin: A New Antitumour Platinum Drug","volume":"10","author":"McKeage","year":"2001","journal-title":"Expert. Opin. Investig. Drugs"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"3868","DOI":"10.1039\/c3cc49516g","article-title":"A Targeted Theranostic Platinum(Iv) Prodrug Containing a Luminogen with Aggregation-Induced Emission (AIE) Characteristics for in Situ Monitoring of Drug Activation","volume":"50","author":"Yuan","year":"2014","journal-title":"Chem. Commun."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1517\/13543784.16.7.1009","article-title":"Broadening the Clinical Use of Platinum Drug-Based Chemotherapy with New Analogues: Satraplatin and Picoplatin","volume":"16","author":"Kelland","year":"2007","journal-title":"Expert. Opin. Investig. Drugs"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2622","DOI":"10.1021\/acs.accounts.5b00203","article-title":"Functionalization of Platinum Complexes for Biomedical Applications","volume":"48","author":"Wang","year":"2015","journal-title":"Acc. Chem. Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"2673","DOI":"10.1039\/c2cs15229k","article-title":"Silica-Based Nanoprobes for Biomedical Imaging and Theranostic Applications","volume":"41","author":"Lin","year":"2012","journal-title":"Chem. Soc. Rev."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1016\/j.addr.2010.08.004","article-title":"Imaging and Drug Delivery Using Theranostic Nanoparticles","volume":"62","author":"Janib","year":"2010","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_44","first-page":"15","article-title":"Emerging Trends in Nano-Theranostics: Platinum-Based Drug Delivery Systems for Cancer Treatment","volume":"8","author":"Asif","year":"2022","journal-title":"Glob. Drug Des. Dev. Rev."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1038\/sj.bjc.6605642","article-title":"Guidelines for the Welfare and Use of Animals in Cancer Research","volume":"102","author":"Workman","year":"2010","journal-title":"Br. J. Cancer"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1021\/ar200094a","article-title":"Supramolecular Nanodevices: From Design Validation to Theranostic Nanomedicine","volume":"44","author":"Cabral","year":"2011","journal-title":"Acc. Chem. Res."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1152\/physrev.00049.2010","article-title":"A Molecular Imaging Primer: Modalities, Imaging Agents, and Applications","volume":"92","author":"James","year":"2012","journal-title":"Physiol. Rev."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"4272","DOI":"10.1007\/s00259-021-05504-y","article-title":"Targeted Optical Fluorescence Imaging: A Meta-Narrative Review and Future Perspectives","volume":"48","author":"Schouw","year":"2021","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1002\/anie.200703994","article-title":"Cellular Uptake Quantification of Metalated Peptide and Peptide Nucleic Acid Bioconjugates by Atomic Absorption Spectroscopy","volume":"47","author":"Kirin","year":"2008","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1039\/B810481F","article-title":"Development of an Experimental Protocol for Uptake Studies of Metal Compounds in Adherent Tumor Cells","volume":"24","author":"Egger","year":"2009","journal-title":"J. Anal. At. Spectrom."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0010-8545(97)00023-4","article-title":"The Influence of Structure on the Activity and Toxicity of Pt Anti-Cancer Drugs","volume":"166","author":"Hambley","year":"1997","journal-title":"Coord. Chem. Rev."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1158\/1078-0432.756.11.2","article-title":"Intracellular Localization and Trafficking of Fluorescein-Labeled Cisplatin in Human Ovarian Carcinoma Cells","volume":"11","author":"Safaei","year":"2005","journal-title":"Clin. Cancer Res."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1007\/s007750000153","article-title":"New Insights in the Cellular Processing of Platinum Antitumor Compounds, Using Fluorophore-Labeled Platinum Complexes and Digital Fluorescence Microscopy","volume":"5","author":"Molenaar","year":"2000","journal-title":"J. Biol. Inorg. Chem."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1002\/jcp.20253","article-title":"Trafficking and Localization of Platinum Complexes in Cisplatin-Resistant Cell Lines Monitored by Fluorescence-Labeled Platinum","volume":"202","author":"Liang","year":"2005","journal-title":"J. Cell. Physiol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1007\/s00775-015-1290-2","article-title":"Evaluation of Fluorophore-Tethered Platinum Complexes to Monitor the Fate of Cisplatin Analogs","volume":"20","author":"Jagodinsky","year":"2015","journal-title":"J. Biol. Inorg. Chem."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1021\/acsmedchemlett.5b00041","article-title":"Mitochondria-Localized Fluorescent BODIPY-Platinum Conjugate","volume":"6","author":"Sun","year":"2015","journal-title":"ACS Med. Chem. Lett."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1002\/cmdc.201300502","article-title":"Platinum Compounds for High-Resolution In Vivo Cancer Imaging","volume":"9","author":"Miller","year":"2014","journal-title":"ChemMedChem"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.ica.2012.07.013","article-title":"Cellular Interactions of Platinum Drugs","volume":"393","author":"Wexselblatt","year":"2012","journal-title":"Inorganica Chim. Acta"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"6312","DOI":"10.1039\/C4CC08077G","article-title":"Fluorescent Sensing of Monofunctional Platinum Species","volume":"51","author":"Shen","year":"2015","journal-title":"Chem. Comm."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"2721","DOI":"10.1016\/j.snb.2017.09.084","article-title":"A Fluorescent Probe for Investigating Metabolic Stability of Active Transplatin Analogues","volume":"255","author":"Kolanowski","year":"2018","journal-title":"Sens. Actuators B Chem."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.jinorgbio.2015.10.002","article-title":"Structure-Activity Relationship Studies on Rhodamine B-Based Fluorogenic Probes and Their Activation by Anticancer Platinum(II) Compounds","volume":"153","author":"Ong","year":"2015","journal-title":"J. Inorg. Biochem."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"12001","DOI":"10.1002\/ange.201305734","article-title":"A Fluorescent Probe for Investigating the Activation of Anticancer Platinum(IV) Prodrugs Based on the Cisplatin Scaffold","volume":"125","author":"Montagner","year":"2013","journal-title":"Angew. Chem."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1002\/anie.201810361","article-title":"A Ratiometric Fluorescent Probe for Cisplatin: Investigating the Intracellular Reduction of Platinum(IV) Prodrug Complexes","volume":"58","author":"Ong","year":"2019","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1002\/asia.202000157","article-title":"Development of a Pre-Assembled Through-Bond Energy Transfer (TBET) Fluorescent Probe for Ratiometric Sensing of Anticancer Platinum(Ll) Complexes","volume":"15","author":"Ong","year":"2020","journal-title":"Chem. Asian J."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1021\/acssensors.1c00161","article-title":"Using a High Quantum Yield Fluorescent Probe with Two-Photon Excitation to Detect Cisplatin in Biological Systems","volume":"6","author":"Fan","year":"2021","journal-title":"ACS Sens."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1021\/bc400281a","article-title":"Synthesis and Characterization of Pt(Iv) Fluorescein Conjugates to Investigate Pt(Iv) Intracellular Transformations","volume":"24","author":"Song","year":"2013","journal-title":"Bioconjug. Chem."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1900260","DOI":"10.1002\/adhm.201900260","article-title":"Beyond 1000 Nm Emission Wavelength: Recent Advances in Organic and Inorganic Emitters for Deep-Tissue Molecular Imaging","volume":"8","author":"Ding","year":"2019","journal-title":"Adv. Healthc. Mater."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Hong, G., Antaris, A.L., and Dai, H. (2017). Near-Infrared Fluorophores for Biomedical Imaging. Nat. Biomed. Eng., 1.","DOI":"10.1038\/s41551-016-0010"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"22702","DOI":"10.1021\/acsomega.0c03218","article-title":"Regulating the Optical Properties of Gold Nanoclusters for Biological Applications","volume":"5","author":"Zhu","year":"2020","journal-title":"ACS Omega"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"679","DOI":"10.7150\/thno.14556","article-title":"Cisplatin Prodrug-Conjugated Gold Nanocluster for Fluorescence Imaging and Targeted Therapy of the Breast Cancer","volume":"6","author":"Zhou","year":"2016","journal-title":"Theranostics"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"13536","DOI":"10.1021\/acsnano.0c05541","article-title":"Illuminating Platinum Transportation While Maximizing Therapeutic Efficacy by Gold Nanoclusters via Simultaneous Near-Infrared-I\/II Imaging and Glutathione Scavenging","volume":"14","author":"Yu","year":"2020","journal-title":"ACS Nano"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1039\/c0nr00950d","article-title":"Conjugated Polyelectrolyte-Cisplatin Complex Nanoparticles for Simultaneous in Vivo Imaging and Drug Tracking","volume":"3","author":"Ding","year":"2011","journal-title":"Nanoscale"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"2527","DOI":"10.1021\/acs.accounts.6b00416","article-title":"Photophysical Properties of Organoplatinum(II) Compounds and Derived Self-Assembled Metallacycles and Metallacages: Fluorescence and Its Applications","volume":"49","author":"Saha","year":"2016","journal-title":"Acc. Chem. Res."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.1073\/pnas.1817021116","article-title":"Rhomboidal Pt(II) Metallacycle-Based NIR-II Theranostic Nanoprobe for Tumor Diagnosis and Image-Guided Therapy","volume":"116","author":"Sun","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"391","DOI":"10.7150\/thno.30268","article-title":"A Novel Multimodal NIR-II Nanoprobe for the Detection of Metastatic Lymph Nodes and Targeting Chemo-Photothermal Therapy in Oral Squamous Cell Carcinoma","volume":"9","author":"Wang","year":"2019","journal-title":"Theranostics"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.dyepig.2017.01.075","article-title":"Near Infrared BODIPY-Platinum Conjugates for Imaging, Photodynamic Therapy and Chemotherapy","volume":"141","author":"Liu","year":"2017","journal-title":"Dye. Pigm."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"108467","DOI":"10.1016\/j.cclet.2023.108467","article-title":"Cisplatin-Appended BODIPY for near Infrared II Fluorescent and Photoacoustic Imaging-Guided Synergistic Phototherapy and Chemotherapy of Cancer","volume":"35","author":"Xing","year":"2024","journal-title":"Chin. Chem. Lett."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.carbon.2018.06.020","article-title":"Functionalization of Single-Walled Carbon Nanohorns for Simultaneous Fluorescence Imaging and Cisplatin Delivery In Vitro","volume":"138","author":"Isaac","year":"2018","journal-title":"Carbon"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.msec.2018.09.020","article-title":"Targeting Graphene Quantum Dots to Epidermal Growth Factor Receptor for Delivery of Cisplatin and Cellular Imaging","volume":"94","author":"Nasrollahi","year":"2019","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Liu, H., Li, C., Qian, Y., Hu, L., Fang, J., Tong, W., Nie, R., Chen, Q., and Wang, H. (2020). Magnetic-Induced Graphene Quantum Dots for Imaging-Guided Photothermal Therapy in the Second near-Infrared Window. Biomaterials, 232.","DOI":"10.1016\/j.biomaterials.2019.119700"},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Chen, Y., Xue, L., Zhu, Q., Feng, Y., and Wu, M. (2021). Recent Advances in Second Near-Infrared Region (NIR-II) Fluorophores and Biomedical Applications. Front. Chem., 9.","DOI":"10.3389\/fchem.2021.750404"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"2426","DOI":"10.1002\/cmdc.202100142","article-title":"Activatable NIR-II Fluorescent Probes Applied in Biomedicine: Progress and Perspectives","volume":"16","author":"Gong","year":"2021","journal-title":"ChemMedChem"},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Cri\u0219an, G., Moldovean-cioroianu, N.S., Timaru, D.G., Andrie\u0219, G., C\u0103inap, C., and Chi\u0219, V. (2022). Radiopharmaceuticals for PET and SPECT Imaging: A Literature Review over the Last Decade. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23095023"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1097\/MNM.0b013e3282f3a515","article-title":"PET versus SPECT: Strengths, Limitations and Challenges","volume":"29","author":"Rahmim","year":"2008","journal-title":"Nucl. Med. Commun."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1002\/jlcr.2580360108","article-title":"Synthesis of Platinum-195m Radiolabelled Cis-Diammine(l,l-Cyclobutanedicarboxylato) Platinum(L1) of High Radionuclidic Purity","volume":"36","author":"Kawai","year":"1995","journal-title":"J. Label. Compd. Radiopharm."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/0883-2889(92)90247-C","article-title":"A New, Semi-Automated System for the Micro-Scale Synthesis of [195mPt]Cisplatin Suitable for Clinical Studies","volume":"43","author":"Anand","year":"1992","journal-title":"Int. J. Rad. Appl. Instr. A"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s10967-015-4053-1","article-title":"Photonuclear Production and Antitumor Effect of Radioactive Cisplatin (195mPt)","volume":"305","author":"Bodnar","year":"2015","journal-title":"J. Radioanal. Nucl. Chem."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0169-409X(99)00059-9","article-title":"Noninvasive Measurements for Studying the Tumoral Pharmacokinetics of Platinum Anticancer Drugs in Solid Tumors","volume":"41","author":"Dowell","year":"2000","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_89","first-page":"222","article-title":"Biodistribution and Dosimetry of 195mPt-Cisplatin in Normal Volunteers. Imaging Agent for Single Photon Emission Computed Tomography","volume":"52","author":"Sathekge","year":"2013","journal-title":"Nucl. Med."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1007\/s00259-017-3643-2","article-title":"Preclinical Imaging Characteristics and Quantification of Platinum-195m SPECT","volume":"44","author":"Aalbersberg","year":"2017","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"55","DOI":"10.2307\/3578568","article-title":"Radiotoxicity of Platinum-195m-Labeled Trans-Platinum (II) in Mammalian Cells","volume":"140","author":"Howell","year":"1994","journal-title":"Radiat. Res."},{"key":"ref_92","unstructured":"Aalbersberg, E.A. (2019). Imaging Biomarker Development and Optimization of 195mPT-Cisplatin and 68Ga-DOTATATE, University of Utrecht."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"5889","DOI":"10.1038\/s41598-020-62039-2","article-title":"Targeting of Radioactive Platinum-Bisphosphonate Anticancer Drugs to Bone of High Metabolic Activity","volume":"10","author":"Nadar","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Nadar, R.A., Franssen, G.M., Van Dijk, N.W.M., van der Schilden, K.C., de Weijert, M., Oosterwijk, E., Iafisco, M., Margiotta, N., Heskamp, S., and van den Beucken, J.J.J.P. (2021). Bone Tumor-Targeted Delivery of Theranostic 195mPt-Bisphosphonate Complexes Promotes Killing of Metastatic Tumor Cells. Mater. Today Bio, 9.","DOI":"10.1016\/j.mtbio.2020.100088"},{"key":"ref_95","unstructured":"Areberg, J. (2000). Studies of Radioactive Cisplatin (191Pt) for Tumour Imaging and Therapy, Lund University."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/S0969-8043(99)00082-2","article-title":"Absorbed Doses to Patients from 191 Pt-, 193m Pt-and 195m Pt-Cisplatin","volume":"51","author":"Areberg","year":"1999","journal-title":"Appl. Radiat. Isot."},{"key":"ref_97","first-page":"528","article-title":"Comparative Renal, Hepatic, and Bone Marrow Toxicity of Cisplatin and Radioactive Cisplatin (191 Pt) in Wistar Rats","volume":"21","author":"Norrgren","year":"2006","journal-title":"Cancer Biother. Radiopharm."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1016\/S0360-3016(99)00543-X","article-title":"In Vitro Toxicity of (191)Pt-Labeled Cisplatin to a Human Cervical Carcinoma Cell Line (ME-180)","volume":"46","author":"Areberg","year":"2000","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/S0360-3016(00)01419-X","article-title":"Antitumor Effect of Radioactive Cisplatin (191Pt) on Nude Mice","volume":"49","author":"Areberg","year":"2001","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Vaidya, S.P., Gadre, S., Kamisetti, R.T., and Patra, M. (2022). Challenges and Opportunities in the Development of Metal-Based Anticancer Theranostic Agents. Biosci. Rep., 42.","DOI":"10.1042\/BSR20212160"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/S0969-8043(96)00323-5","article-title":"[13N]Cisplatin: A Fast and Efficient On-Line Synthesis Using a Solid State Support","volume":"48","author":"Holschbach","year":"1997","journal-title":"Appl. Radial. Isot."},{"key":"ref_102","first-page":"399","article-title":"Microscale Synthesis of Nitrogen-13-Labeled Cisplatin","volume":"27","author":"Slegers","year":"1986","journal-title":"J. Nucl. Med."},{"key":"ref_103","first-page":"1844","article-title":"[13N]Cisplatin PET to Assess Pharmacokinetics of Intra-ArterialVersus Intravenous Chemotherapy for Malignant Brain Tumors","volume":"28","author":"Ginos","year":"1987","journal-title":"J. Nucl. Med."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.2967\/jnumed.117.191965","article-title":"18F-Labeled Carboplatin Derivative for PET Imaging of Platinum Drug Distribution","volume":"58","author":"Lamichhane","year":"2017","journal-title":"J. Nucl. Med."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"2853","DOI":"10.1002\/ejoc.200800114","article-title":"Chemistry with [18F]Fluoride Ion","volume":"2008","author":"Cai","year":"2008","journal-title":"Eur. J. Org. Chem."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2310\/7290.2010.00008","article-title":"Unconventional Nuclides for Radiopharmaceuticals","volume":"9","author":"Holland","year":"2010","journal-title":"Mol. Imaging"},{"key":"ref_107","doi-asserted-by":"crossref","unstructured":"Lamichhane, N., Dewkar, G.K., Sundaresan, G., Mahon, R.N., and Zweit, J. (2017). [18F]-Fluorinated Carboplatin and [111in]-Liposome for Image-Guided Drug Delivery. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18051079"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"e202202604","DOI":"10.1002\/chem.202202604","article-title":"PET Imaging of Self-Assembled 18F-Labelled Pd2L4 Metallacages for Anticancer Drug Delivery","volume":"29","author":"Cosialls","year":"2023","journal-title":"Chem. Eur. J."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"215366","DOI":"10.1016\/j.ccr.2023.215366","article-title":"Biomedical Applications of Multinuclear Pt(II)\/Ru(II)\/Ir(III) Metallo-Supramolecular Assemblies for Intensive Cancer Therapy","volume":"495","author":"Li","year":"2023","journal-title":"Coord. Chem. Rev."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"6765","DOI":"10.1021\/acs.jmedchem.1c00039","article-title":"High Cytotoxic Effect by Combining Copper-64 with a NOTA-Terpyridine Platinum Conjugate","volume":"64","author":"Khosravifarsani","year":"2021","journal-title":"J. Med. Chem."},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Khosravifarsani, M., Ait-Mohand, S., Paquette, B., Sanche, L., and Gu\u00e9rin, B. (2021). Design, Synthesis, and Cytotoxicity Assessment of [64cu]Cu-Nota-Terpyridine Platinum Conjugate: A Novel Chemoradiotherapeutic Agent with Flexible Linker. Nanomaterials, 11.","DOI":"10.3390\/nano11092154"},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Gutfilen, B., Mendes, F., and Gu\u00e9rin, B. (2022). In Vivo Behaviour of [64Cu]NOTA-Terpyridine Platinum, a Novel Chemo-Radio-Theranostic Agent for Imaging, and Theraphy of Colorectal Cancer. Front. Med., 9.","DOI":"10.3389\/fmed.2022.975213"},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Lo, R., Majid, A., Fruhwirth, G.O., and Vilar, R. (2022). Radiolabelling Pt-Based Quadruplex DNA Binders via Click Chemistry. Bioorg. Med. Chem., 76.","DOI":"10.1016\/j.bmc.2022.117097"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"20745","DOI":"10.1021\/acs.inorgchem.3c02245","article-title":"Radiometal-Labeled Photoactivatable Pt(IV) Anticancer Complex for Theranostic Phototherapy","volume":"62","author":"Imberti","year":"2023","journal-title":"Inorg. Chem."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1038\/nature06917","article-title":"Imaging in the Era of Molecular Oncology","volume":"452","author":"Weissleder","year":"2008","journal-title":"Nature"},{"key":"ref_116","first-page":"65","article-title":"Magnetic Resonance Imaging (MRI)\u2014A Review","volume":"3","author":"Ara","year":"2011","journal-title":"Int. J. Clin. Dent."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1039\/C4CS00336E","article-title":"Recent Advances in Gd-Chelate Based Bimodal Optical\/MRI Contrast Agents","volume":"44","author":"Verwilst","year":"2015","journal-title":"Chem. Soc. Rev."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.jconrel.2007.05.024","article-title":"Optimization of (1,2-Diamino-Cyclohexane)Platinum(II)-Loaded Polymeric Micelles Directed to Improved Tumor Targeting and Enhanced Antitumor Activity","volume":"121","author":"Cabral","year":"2007","journal-title":"J. Control. Release"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1021\/acs.chemrev.8b00363","article-title":"Chemistry of MRI Contrast Agents: Current Challenges and New Frontiers","volume":"119","author":"Wahsner","year":"2019","journal-title":"Chem. Rev."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12325-015-0275-4","article-title":"25 Years of Contrast-Enhanced MRI: Developments, Current Challenges and Future Perspectives","volume":"33","author":"Lohrke","year":"2016","journal-title":"Adv. Ther."},{"key":"ref_121","unstructured":"Medical Imaging Drugs Advisory Committee Meeting (2024, April 25). Gadolinium Retention after Gadolinium Based Contrast Magnetic Resonance Imaging in Patients with Normal Renal Function Briefing Document, Available online: https:\/\/www.fda.gov\/media\/107133\/download."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"751","DOI":"10.2174\/0929867053507379","article-title":"Gadolinium Meets Medicinal Chemistry: MRI Contrast Agent Development","volume":"12","author":"Zhang","year":"2005","journal-title":"Curr. Med. Chem."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1097\/JTO.0b013e31811f4719","article-title":"Phase I Trial of Motexafin Gadolinium in Combination with Docetaxel and Cisplatin for the Treatment of Non-Small Cell Lung Cancer","volume":"2","author":"William","year":"2007","journal-title":"J. Thorac. Oncol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1118\/1.596817","article-title":"Gadolinium as Xda Neutron Capture Therapy Agent","volume":"19","author":"Brugger","year":"1992","journal-title":"Med. Phys."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1007\/s11172-005-0045-6","article-title":"Boron and Gadolinium Neutron Capture Therapy","volume":"53","author":"Salt","year":"2004","journal-title":"Russ. Chem. Bull."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"3402","DOI":"10.1021\/acs.bioconjchem.8b00565","article-title":"DOTA Functionalized Cross-Linked Small-Molecule Micelles for Theranostics Combining Magnetic Resonance Imaging and Chemotherapy","volume":"29","author":"Feng","year":"2018","journal-title":"Bioconjug. Chem."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"7031","DOI":"10.1158\/0008-5472.CAN-10-0303","article-title":"Visible Drug Delivery by Supramolecular Nanocarriers Directing to Single-Platformed Diagnosis and Therapy of Pancreatic Tumor Model","volume":"70","author":"Kaida","year":"2010","journal-title":"Cancer Res."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"2605","DOI":"10.1039\/c3sc50554e","article-title":"A Platinum Anticancer Theranostic Agent with Magnetic Targeting Potential Derived from Maghemite Nanoparticles","volume":"4","author":"Wang","year":"2013","journal-title":"Chem. Sci."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"7551","DOI":"10.1021\/acs.nanolett.6b03378","article-title":"Nanodiamond-Gadolinium(III) Aggregates for Tracking Cancer Growth in Vivo at High Field","volume":"16","author":"Rammohan","year":"2016","journal-title":"Nano Lett."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"4231","DOI":"10.1039\/D0CS01075H","article-title":"Gadolinium Theranostics for the Diagnosis and Treatment of Cancer","volume":"50","author":"Robertson","year":"2021","journal-title":"Chem. Soc. Rev."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1002\/anie.200902309","article-title":"Selective Aggregation of a Platinum-Gadolinium Complex within a Tumor-Cell Nucleus","volume":"49","author":"Crossley","year":"2010","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1071\/CH14572","article-title":"Synthesis and DNA-Binding Studies of a Dinuclear Gadolinium(Iii)-Platinum(Ii) Complex","volume":"68","author":"Fenton","year":"2015","journal-title":"Aust. J. Chem."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"13225","DOI":"10.1002\/anie.201407406","article-title":"Platinum(II)-Gadolinium(III) Complexes as Potential Single-Molecular Theranostic Agents for Cancer Treatment","volume":"53","author":"Zhu","year":"2014","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_134","first-page":"739","article-title":"A Phase I Single-Dose Trial of Gadolinium Texaphyrin (Gd-Tex), a Tumor Selective Radiation Sensitizer Detectable by Magnetic Resonance Imaging","volume":"5","author":"Rosenthal","year":"1999","journal-title":"Clin. Cancer Res."},{"key":"ref_135","doi-asserted-by":"crossref","unstructured":"Pica, A., Rosenthal, D.I., Koprowski, C., Schea, R., Ruckle, J., Tishler, R., Larner, J.M., Arwood, D., Haie-Meder, C., and Young, S. (1997). A Phase Multi-Dose Trial of Gadolinium-Texaphyrin (Gd-Tex) as a Radiosensitizer in Patients with Brain Metastases Treated with Conventional Radiation Therapy: Preliminary Results. Int. J. Radiat. Oncol. Biol. Phys., 39.","DOI":"10.1016\/S0360-3016(97)80828-0"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/S0360-3016(99)00274-6","article-title":"In Vivo Animal Studies with Gadolinium (III) Texaphyrin as a Radiation Enhancer","volume":"45","author":"Miller","year":"1999","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1002\/jpp.326","article-title":"Texaphyrins: A New Approach to Drug Development","volume":"5","author":"Mody","year":"2001","journal-title":"J. Porphyr. Phthalocyanines"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1351\/pac200476020365","article-title":"Synthesis of Texaphyrin Conjugates","volume":"76","author":"Magda","year":"2004","journal-title":"Pure Appl. Chem."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"10834","DOI":"10.1039\/b912089k","article-title":"Gadolinium Texaphyrin (Gd-Tex)-Malonato-Platinum Conjugates: Synthesis Comparison with Carboplatin in Normal and Pt-Resistant Cell Lines","volume":"48","author":"Arambula","year":"2009","journal-title":"Dalton Trans."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1016\/j.bmcl.2011.01.092","article-title":"Overcoming Biochemical Pharmacologic Mechanisms of Platinum Resistance with a Texaphyrin-Platinum Conjugate","volume":"21","author":"Arambula","year":"2011","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1039\/c2md20206a","article-title":"A Texaphyrin-Oxaliplatin Conjugate That Overcomes Both Pharmacologic and Molecular Mechanisms of Cisplatin Resistance in Cancer Cells","volume":"3","author":"Arambula","year":"2012","journal-title":"Medchemcomm"},{"key":"ref_142","first-page":"8942","article-title":"Photoinduced Reduction of Pt(IV) within an Anti-Proliferative Pt(IV)-Texaphyrin Conjugate","volume":"20","author":"Thiabaud","year":"2014","journal-title":"Chemistry"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"7021","DOI":"10.1073\/pnas.1914911117","article-title":"Oxaliplatin Pt(IV) Prodrugs Conjugated to Gadolinium-Texaphyrin as Potential Antitumor Agents","volume":"117","author":"Thiabaud","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"12816","DOI":"10.1002\/ange.201604236","article-title":"Activation of Platinum(IV) Prodrugs By Motexafin Gadolinium as a Redox Mediator","volume":"128","author":"Thiabaud","year":"2016","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"2524","DOI":"10.1039\/C9SC05937G","article-title":"Gd(III)-Pt(IV) Theranostic Contrast Agents for Tandem MR Imaging and Chemotherapy","volume":"11","author":"Adams","year":"2020","journal-title":"Chem. Sci."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"3663","DOI":"10.1002\/cmdc.202100389","article-title":"Towards Imaging Pt Chemoresistance Using Gd(III)-Pt(II) Theranostic MR Contrast Agents","volume":"16","author":"Adams","year":"2021","journal-title":"ChemMedChem"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1080\/21691401.2018.1457039","article-title":"Nanoparticles as Carriers for Drug Delivery in Cancer","volume":"46","author":"Dadwal","year":"2018","journal-title":"Artif. Cells Nanomed. Biotechnol."},{"key":"ref_148","first-page":"133","article-title":"Drug Delivery and Nanoparticles: Applications and Hazards","volume":"3","author":"Borm","year":"2008","journal-title":"Int. J. Nanomed."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0168-3659(99)00248-5","article-title":"Tumor Vascular Permeability and the EPR Effect in Macromolecular Therapeutics: A Review","volume":"65","author":"Maeda","year":"2000","journal-title":"J. Control. Release"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1111\/j.1349-7006.2009.01103.x","article-title":"Preclinical and Clinical Studies of Anticancer Agent-Incorporating Polymer Micelles","volume":"100","author":"Matsumura","year":"2009","journal-title":"Cancer Sci."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1016\/j.msec.2019.01.066","article-title":"Employment of Enhanced Permeability and Retention Effect (EPR): Nanoparticle-Based Precision Tools for Targeting of Therapeutic and Diagnostic Agent in Cancer","volume":"98","author":"Kalyane","year":"2019","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_152","doi-asserted-by":"crossref","unstructured":"Ganesan, K., Wang, Y., Gao, F., Liu, Q., Zhang, C., Li, P., Zhang, J., and Chen, J. (2021). Targeting Engineered Nanoparticles for Breast Cancer Therapy. Pharmaceutics, 13.","DOI":"10.3390\/pharmaceutics13111829"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s40580-019-0193-2","article-title":"Current Trends and Challenges in Cancer Management and Therapy Using Designer Nanomaterials","volume":"6","author":"Navya","year":"2019","journal-title":"Nano Converg."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"179","DOI":"10.3109\/1061186X.2015.1051049","article-title":"Nanocarriers for Cancer-Targeted Drug Delivery","volume":"24","author":"Kumari","year":"2016","journal-title":"J. Drug Target."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s12645-012-0029-9","article-title":"Delivery of Nanoparticles to Brain Metastases of Breast Cancer Using a Cellular Trojan Horse","volume":"3","author":"Choi","year":"2012","journal-title":"Cancer Nanotechnol."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"6207","DOI":"10.2147\/IJN.S176928","article-title":"Gold Nanoparticles Enhance Cisplatin Delivery and Potentiate Chemotherapy by Decompressing Colorectal Cancer Vessels","volume":"13","author":"Zhao","year":"2018","journal-title":"Int. J. Nanomed."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"8984","DOI":"10.1021\/acs.langmuir.9b00954","article-title":"Loading of Cisplatin into Mesoporous Silica Nanoparticles: Effect of Surface Functionalization","volume":"35","author":"Varache","year":"2019","journal-title":"Langmuir"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.jconrel.2004.08.022","article-title":"Preparation and Biological Properties of Dichloro (1,2-Diaminocyclohexane) Platinum(II) (DACHPt)-Loaded Polymeric Micelles","volume":"101","author":"Cabral","year":"2005","journal-title":"J. Control. Release"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"715","DOI":"10.2217\/nnm.11.19","article-title":"Nanoparticle PEGylation for Imaging and Therapy","volume":"6","author":"Jokerst","year":"2011","journal-title":"Nanomedicine"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1016\/j.addr.2008.03.014","article-title":"Multifunctional Magnetic Nanoparticles for Targeted Imaging and Therapy","volume":"60","author":"McCarthy","year":"2008","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1200\/jco.2006.24.18_suppl.2018","article-title":"Phase I Study of NK105, a Paclitaxel-Incorporating Micellar Nanoparticle, in Patients with Advanced Cancer","volume":"24","author":"Kato","year":"2006","journal-title":"J. Clin. Oncol."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"2573","DOI":"10.1200\/jco.2008.26.15_suppl.2573","article-title":"Phase I and Pharmacokinetic Study of NC-6004, a New Platinum Entity of Cisplatin-Conjugated Polymer Forming Micelles","volume":"26","author":"Wilson","year":"2008","journal-title":"J. Clin. Oncol."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1007\/BF02668092","article-title":"Mixed Micelles Containing Lipophilic Gadolinium Complexes as MRA Contrast Agents","volume":"12","author":"Anelli","year":"2001","journal-title":"Magn. Reson. Mater. Phys. Biol. Med."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"60945","DOI":"10.1039\/C6RA07782J","article-title":"Gadolinium(III) Based Nanoparticles for: T1-Weighted Magnetic Resonance Imaging Probes","volume":"6","author":"Yang","year":"2016","journal-title":"RSC Adv."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.jconrel.2021.02.031","article-title":"Polymeric Micelles in Drug Delivery: An Insight of the Techniques for Their Characterization and Assessment in Biorelevant Conditions","volume":"332","author":"Ghezzi","year":"2021","journal-title":"J. Control. Release"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.pharmthera.2006.05.006","article-title":"Current State, Achievements, and Future Prospects of Polymeric Micelles as Nanocarriers for Drug and Gene Delivery","volume":"112","author":"Nishiyama","year":"2006","journal-title":"Pharmacol. Ther."},{"key":"ref_167","first-page":"4137","article-title":"MRI-Detectable Polymeric Micelles Incorporating Platinum Anticancer Drugs Enhance Survival in an Advanced Hepatocellular Carcinoma Model","volume":"10","author":"Vinh","year":"2015","journal-title":"Int. J. Nanomed."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"4406","DOI":"10.1021\/jp7108785","article-title":"Effect of Crystallographic Structure of MnO2 on Its Electrochemical Capacitance Properties","volume":"112","author":"Devaraj","year":"2008","journal-title":"J. Phys. Chem. C"},{"key":"ref_169","first-page":"1759","article-title":"Manganese Dioxide Nanosheets-Based Redox\/PH-Responsive Drug Delivery System for Cancer Theranostic Application","volume":"11","author":"Hao","year":"2016","journal-title":"Int. J. Nanomed."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1002\/chem.201704861","article-title":"Tunable Performance of Manganese Oxide Nanostructures as MRI Contrast Agents","volume":"24","author":"Cerqueira","year":"2018","journal-title":"Chem. Eur. J."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"10763","DOI":"10.1039\/D3NR00076A","article-title":"Redox Double-Switch Cancer Theranostics through Pt(Iv) Functionalised Manganese Dioxide Nanostructures","volume":"15","author":"Brito","year":"2023","journal-title":"Nanoscale"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1039\/D2TB01659A","article-title":"A Novel Manganese Dioxide-Based Drug Delivery Strategy via in Situ Coating \u03b3-Polyglutamic Acid\/Cisplatin for Intelligent Anticancer Therapy","volume":"11","author":"Zhang","year":"2023","journal-title":"J. Mater. Chem. B"},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1002\/mrm.1910050404","article-title":"Transverse Relaxation of Solvent Protons Induced by Magnetized Spheres: Application to Feffitin, Erythrocytes, and Magnetite","volume":"5","author":"Grllrs","year":"1987","journal-title":"Magn. Reson. Med."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"5418","DOI":"10.7150\/thno.53346","article-title":"Manganese-Deposited Iron Oxide Promotes Tumor-Responsive Ferroptosis That Synergizes the Apoptosis of Cisplatin","volume":"11","author":"Cheng","year":"2021","journal-title":"Theranostics"},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"2786","DOI":"10.1039\/c3cc39059d","article-title":"Detecting and Delivering Platinum Anticancer Drugs Using Fluorescent Maghemite Nanoparticles","volume":"49","author":"Wang","year":"2013","journal-title":"Chem. Commun."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1021\/acs.bioconjchem.8b00052","article-title":"Multifunctional Porous Iron Oxide Nanoagents for MRI and Photothermal\/Chemo Synergistic Therapy","volume":"29","author":"Hu","year":"2018","journal-title":"Bioconjug. Chem."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"11142","DOI":"10.1039\/c1jm11369k","article-title":"Superparamagnetic Magnetite Nanocrystal Clusters as Potential Magnetic Carriers for the Delivery of Platinum Anticancer Drugs","volume":"21","author":"Xing","year":"2011","journal-title":"J. Mater. Chem."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"2864","DOI":"10.1039\/C5SC04049C","article-title":"Glutathione Boosting the Cytotoxicity of a Magnetic Platinum(Iv) Nano-Prodrug in Tumor Cells","volume":"7","author":"Zhu","year":"2016","journal-title":"Chem. Sci."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"3066","DOI":"10.1039\/C8PY01535J","article-title":"Design and Synthesis of a Dual Imageable Theranostic Platinum Prodrug for Efficient Cancer Therapy","volume":"10","author":"Mukherjee","year":"2019","journal-title":"Polym. Chem."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"186","DOI":"10.7150\/ntno.18619","article-title":"Gadolinium and Platinum in Tandem: Real-Time Multi-Modal Monitoring of Drug Delivery by Mri and Fluorescence Imaging","volume":"1","author":"Li","year":"2017","journal-title":"Nanotheranostics"}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/29\/15\/3453\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:22:00Z","timestamp":1760109720000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/29\/15\/3453"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,23]]},"references-count":180,"journal-issue":{"issue":"15","published-online":{"date-parts":[[2024,8]]}},"alternative-id":["molecules29153453"],"URL":"https:\/\/doi.org\/10.3390\/molecules29153453","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,23]]}}}